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1 UNITED STATES SECURITIES AND EXCHANGE COMMISSION WASHINGTON, D.C. 20549 SCHEDULE 13G UNDER THE SECURITIES EXCHANGE ACT OF 1934 (AMENDMENT NO. )* BIOCRYST PHARMACEUTICALS, INC. (Name of Issuer) COMMON STOCK (Title of Class of Securities) 09058V 10 3 (CUSIP Number) October 21, 1998 (Date of Event Which Requires Filing of this Statement) Check the appropriate box to designate the rule pursuant to which this Schedule is filed: [ ] Rule 13d-1(b) [X] Rule 13d-1(c) [ ] Rule 13d-1(d) *The remainder of this cover page shall be filled out for a reporting person's initial filing on this form with respect to the subject class of securities, and for any subsequent amendment containing information which would alter disclosures provided in a prior cover page. The information required on the remainder of this cover page shall not be deemed to be "filed" for the purpose of Section 18 of the Securities Exchange Act of 1934 ("Act") or otherwise subject to the liabilities of that section of the Act but shall be subject to all other provisions of the Act (however, see the Notes). Page 1 of 7 Pages 2 SCHEDULE 13G CUSIP NO. 09058V 10 3 PAGE 2 OF 7 PAGES - -------------------------------------------------------------------------------- 1 NAME OF REPORTING PERSON S.S. OR I.R.S. IDENTIFICATION NO. OF ABOVE PERSON Johnson & Johnson 22-1024240 - -------------------------------------------------------------------------------- 2 CHECK THE APPROPRIATE BOX IF A MEMBER OF A GROUP* (a) [ ] (b) [ ] - -------------------------------------------------------------------------------- 3 SEC USE ONLY - -------------------------------------------------------------------------------- 4 CITIZENSHIP OR PLACE OF ORGANIZATION New Jersey - -------------------------------------------------------------------------------- NUMBER OF 5 SOLE VOTING POWER SHARES BENEFICIALLY -0- OWNED BY EACH ------------------------------------------------------------ REPORTING 6 SHARED VOTING POWER PERSON WITH 918,836 ------------------------------------------------------------ 7 SOLE DISPOSITIVE POWER -0- ------------------------------------------------------------ 8 SHARED DISPOSITIVE POWER 918,836 - -------------------------------------------------------------------------------- 9 AGGREGATE AMOUNT BENEFICIALLY OWNED BY EACH REPORTING PERSON 918,836 - -------------------------------------------------------------------------------- 10 CHECK BOX IF THE AGGREGATE AMOUNT IN ROW (11) EXCLUDES CERTAIN SHARES* [ ] - -------------------------------------------------------------------------------- 11 PERCENT OF CLASS REPRESENTED BY AMOUNT IN ROW (11) 6.17% - -------------------------------------------------------------------------------- 12 TYPE OF REPORTING PERSON* CO - -------------------------------------------------------------------------------- *SEE INSTRUCTIONS BEFORE FILLING OUT! 3 SCHEDULE 13G CUSIP NO. 09058V 10 3 PAGE 3 OF 7 PAGES - -------------------------------------------------------------------------------- 1 NAME OF REPORTING PERSON S.S. OR I.R.S. IDENTIFICATION NO. OF ABOVE PERSON Johnson & Johnson Development Corporation 22-2007137 - -------------------------------------------------------------------------------- 2 CHECK THE APPROPRIATE BOX IF A MEMBER OF A GROUP* (a) [ ] (b) [ ] - -------------------------------------------------------------------------------- 3 SEC USE ONLY - -------------------------------------------------------------------------------- 4 CITIZENSHIP OR PLACE OF ORGANIZATION New Jersey - -------------------------------------------------------------------------------- NUMBER OF 5 SOLE VOTING POWER SHARES BENEFICIALLY -0- OWNED BY EACH ------------------------------------------------------------ REPORTING 6 SHARED VOTING POWER PERSON WITH 918,836 ------------------------------------------------------------ 7 SOLE DISPOSITIVE POWER -0- ------------------------------------------------------------ 8 SHARED DISPOSITIVE POWER 918,836 - -------------------------------------------------------------------------------- 9 AGGREGATE AMOUNT BENEFICIALLY OWNED BY EACH REPORTING PERSON 918,836 - -------------------------------------------------------------------------------- 10 CHECK BOX IF THE AGGREGATE AMOUNT IN ROW (11) EXCLUDES CERTAIN SHARES* [ ] - -------------------------------------------------------------------------------- 11 PERCENT OF CLASS REPRESENTED BY AMOUNT IN ROW (11) 6.17% - -------------------------------------------------------------------------------- 12 TYPE OF REPORTING PERSON* CO - -------------------------------------------------------------------------------- *SEE INSTRUCTIONS BEFORE FILLING OUT! 4 CUSIP 09058V 10 3 Page 4 of 7 Pages Item 1. Name and Address of Issuer: Biocryst Pharmaceuticals, Inc. 2190 Parkway Lake Drive Birmingham, Alabama 35244 Item 2. (a) Name of Person Filing: Johnson & Johnson ("J&J") Johnson & Johnson Development corporation ("JJDC") (b) Address of Principal Business Office of J&J and JJDC: One Johnson & Johnson Plaza, New Brunswick, New Jersey 08933 (c) Place of Organization or Citizenship: J&J and JJDC are both New Jersey corporations (d) Title of Class of Securities: Common Stock, par value $.01 (e) CUSIP Number: 09058V 10 3 Item 3. This statement is filed pursuant to Rule 13d-1(c) by J&J and JJDC. Item 4. Ownership: (a) Amount Beneficially Owned by J&J and JJDC J&J 918,836 JJDC 918,836 (b) Percent of Class: J&J 6.17% JJDC 6.17% 5 CUSIP 09058V 10 3 Page 5 of 7 Pages (c) Number of Shares as to which the filing person has: (i) sole power to vote or to direct the vote J&J 0 JJDC 0 (ii) shared power to vote or to direct the vote J&J 918,836 JJDC 918,836 (iii) sole power to dispose or to direct the disposition of J&J 0 JJDC 0 (iv) shared power to dispose or to direct the disposition of JJDC 918,836 J&J 918,836 Item 5. Ownership of Five Percent or Less of a Class: Not applicable Item 6. Ownership of More Than Five Percent on Behalf of Another Person: Not applicable Item 7. Identification and Classification of Subsidiaries which Acquired the Security Being Reported on by the Parent Holding Company: Not applicable Item 8. Identification and Classification of Members of the Group: Not applicable 6 CUSIP 09058V 10 3 Page 6 of 7 Pages Item 9. Notice of Dissolution of Group: Not applicable Item 10. Certification: By signing below I certify that, to the best of my knowledge and belief, the securities referred to above were not acquired and are not held for the purpose of or with the effect of changing or influencing the control of the issuer of the securities and were not acquired and are not held in connection with or as a participant in any transaction having that purpose or effect. 7 CUSIP 09058V 10 3 Page 7 of 7 Pages SIGNATURE After reasonable inquiry and to the best of my knowledge and belief, I certify that the information set forth in this statement is true, complete and correct. JOHNSON & JOHNSON By: /s/Peter S. Galloway Name: Peter S. Galloway Title: Secretary Dated: October 27, 1998 JOHNSON & JOHNSON DEVELOPMENT CORPORATION By: /s/Peter S. Galloway Name: Peter S. Galloway Title: Secretary Dated: October 27, 1998