Schedule 13G

SECURITIES AND EXCHANGE COMMISSION
Washington, DC 20549


SCHEDULE 13G
(Rule 13d-102)

INFORMATION TO BE INCLUDED IN STATEMENTS FILED PURSUANT
TO RULES 13d-1(b) (c) AND (d) AND AMENDMENTS THERETO FILED
PURSUANT TO 13d-2(b)
(Amendment No. 1)*

    Biocryst Pharmaceuticals Inc.
(Name of Issuer)
   

 

 

 

 

 
    Common Stock
(Title of Class of Securities)
   

 

 

 

 

 
    09058V 10 3
(CUSIP Number)
   

 

 

 

 

 
    December 8, 2003
(Date of Event Which Requires Filing of this Statement)
   

 

 

 

 

 

Check the appropriate box to designate the rule pursuant to which this Schedule is filed:

      o
      Rule 13d-1(b)
      x
      Rule 13d-1(c)
      o
      Rule 13d-1(d)

*
The remainder of this cover page shall be filled out for a reporting person's initial filing on this form with respect to the subject class of securities, and for any subsequent amendment containing information which would alter disclosures provided in a prior cover page.

    The information required on the remainder of this cover page shall not be deemed to be "filed" for the purpose of Section 18 of the ” Securities Exchange Act of 1934 (“Act) or otherwise subject to the liabilities of that section of the Act but shall be subject to all other provisions of the Act (however, see the Notes).



     
CUSIP NO. 09058V 10 3   13G   Page 2 of 10 Pages

     

1   NAME OF REPORTING PERSON:
I.R.S. IDENTIFICATION NO. OF ABOVE PERSON (ENTITIES ONLY):
   

 

 

Biotechnology Value Fund, L.P.

 

 

2   CHECK THE APPROPRIATE BOX IF A MEMBER OF A GROUP*    
        (a)x
        (b)o

3   SEC USE ONLY    

 

 

 

 

 

4   CITIZENSHIP OR PLACE OF ORGANIZATION    

 

 

Delaware

 

 

  5   SOLE VOTING POWER
NUMBER     0
OF    
SHARES 6   SHARED VOTING POWER
BENEFICIALLY     9,600
OWNED BY    
EACH 7   SOLE DISPOSITIVE POWER
REPORTING     0
PERSON    
WITH 8   SHARED DISPOSITIVE POWER
      9,600

9   AGGREGATE AMOUNT BENEFICIALLY OWNED BY EACH REPORTING PERSON    

 

 

9,600

 

 

10   CHECK BOX IF THE AGGREGATE AMOUNT IN ROW (9) EXCLUDES CERTAIN SHARES*    

 

 

 

 

o

11   PERCENT OF CLASS REPRESENTED BY AMOUNT IN ROW 9    

 

 

0.05%

 

 

12   TYPE OF REPORTING PERSON*    

 

 

PN

 

 

* SEE INSTRUCTIONS BEFORE FILLING OUT!

 

 

 

 

 


     
CUSIP NO. 09058V 10 3   13G   Page 3 of 10 Pages

     

1   NAME OF REPORTING PERSON:
I.R.S. IDENTIFICATION NO. OF ABOVE PERSON (ENTITIES ONLY):
   

 

 

Biotechnology Value Fund II, L.P.

 

 

2   CHECK THE APPROPRIATE BOX IF A MEMBER OF A GROUP*    
        (a)x
        (b)o

3   SEC USE ONLY    

 

 

 

 

 

4   CITIZENSHIP OR PLACE OF ORGANIZATION    

 

 

Delaware

 

 

  5   SOLE VOTING POWER
NUMBER     0
OF    
SHARES 6   SHARED VOTING POWER
BENEFICIALLY     0
OWNED BY    
EACH 7   SOLE DISPOSITIVE POWER
REPORTING     0
PERSON    
WITH 8   SHARED DISPOSITIVE POWER
      0

9   AGGREGATE AMOUNT BENEFICIALLY OWNED BY EACH REPORTING PERSON    

 

 

0

 

 

10   CHECK BOX IF THE AGGREGATE AMOUNT IN ROW (9) EXCLUDES CERTAIN SHARES*    

 

 

 

 

o

11   PERCENT OF CLASS REPRESENTED BY AMOUNT IN ROW 9    

 

 

0.00%

 

 

12   TYPE OF REPORTING PERSON*    

 

 

PN

 

 

* SEE INSTRUCTIONS BEFORE FILLING OUT!

 

 

 

 

 


     
CUSIP NO. 09058V 10 3   13G   Page 4 of 10 Pages

     

1   NAME OF REPORTING PERSON:
I.R.S. IDENTIFICATION NO. OF ABOVE PERSON (ENTITIES ONLY):
   

 

 

BVF Investments, L.L.C.

 

 

2   CHECK THE APPROPRIATE BOX IF A MEMBER OF A GROUP*    
        (a)x
        (b)o

3   SEC USE ONLY    

 

 

 

 

 

4   CITIZENSHIP OR PLACE OF ORGANIZATION    

 

 

Delaware

 

 

  5   SOLE VOTING POWER
NUMBER     0
OF    
SHARES 6   SHARED VOTING POWER
BENEFICIALLY     0
OWNED BY    
EACH 7   SOLE DISPOSITIVE POWER
REPORTING     0
PERSON    
WITH 8   SHARED DISPOSITIVE POWER
      0

9   AGGREGATE AMOUNT BENEFICIALLY OWNED BY EACH REPORTING PERSON    

 

 

0

 

 

10   CHECK BOX IF THE AGGREGATE AMOUNT IN ROW (9) EXCLUDES CERTAIN SHARES*    

 

 

 

 

o

11   PERCENT OF CLASS REPRESENTED BY AMOUNT IN ROW 9    

 

 

0.00%

 

 

12   TYPE OF REPORTING PERSON*    

 

 

OO

 

 

* SEE INSTRUCTIONS BEFORE FILLING OUT!

 

 

 

 

 


     
CUSIP NO. 09058V 10 3   13G   Page 5 of 10 Pages

     

1   NAME OF REPORTING PERSON:
I.R.S. IDENTIFICATION NO. OF ABOVE PERSON (ENTITIES ONLY):
   

 

 

Investment 10, L.L.C.

 

 

2   CHECK THE APPROPRIATE BOX IF A MEMBER OF A GROUP*    
        (a)x
        (b)o

3   SEC USE ONLY    

 

 

 

 

 

4   CITIZENSHIP OR PLACE OF ORGANIZATION    

 

 

Illinois

 

 

  5   SOLE VOTING POWER
NUMBER     0
OF    
SHARES 6   SHARED VOTING POWER
BENEFICIALLY     0
OWNED BY    
EACH 7   SOLE DISPOSITIVE POWER
REPORTING     0
PERSON    
WITH 8   SHARED DISPOSITIVE POWER
      0

9   AGGREGATE AMOUNT BENEFICIALLY OWNED BY EACH REPORTING PERSON    

 

 

0

 

 

10   CHECK BOX IF THE AGGREGATE AMOUNT IN ROW (9) EXCLUDES CERTAIN SHARES*    

 

 

 

 

o

11   PERCENT OF CLASS REPRESENTED BY AMOUNT IN ROW 9    

 

 

0.00%

 

 

12   TYPE OF REPORTING PERSON*    

 

 

OO

 

 

* SEE INSTRUCTIONS BEFORE FILLING OUT!

 

 

 

 

 


     
CUSIP NO. 09058V 10 3   13G   Page 6 of 10 Pages

     

1   NAME OF REPORTING PERSON:
I.R.S. IDENTIFICATION NO. OF ABOVE PERSON (ENTITIES ONLY):
   

 

 

BVF Partners L.P.

 

 

2   CHECK THE APPROPRIATE BOX IF A MEMBER OF A GROUP*    
        (a)x
        (b)o

3   SEC USE ONLY    

 

 

 

 

 

4   CITIZENSHIP OR PLACE OF    

 

 

Delaware

 

 

  5   SOLE VOTING POWER
NUMBER     0
OF    
SHARES 6   SHARED VOTING POWER
BENEFICIALLY     9,600
OWNED BY    
EACH 7   SOLE DISPOSITIVE POWER
REPORTING     0
PERSON    
WITH 8   SHARED DISPOSITIVE POWER
      9,600

9   AGGREGATE AMOUNT BENEFICIALLY OWNED BY EACH REPORTING PERSON    

 

 

9,600

 

 

10   CHECK BOX IF THE AGGREGATE AMOUNT IN ROW (9) EXCLUDES CERTAIN SHARES*    

 

 

 

 

o

11   PERCENT OF CLASS REPRESENTED BY AMOUNT IN ROW 9    

 

 

0.05%

 

 

12   TYPE OF REPORTING PERSON*    

 

 

PN

 

 

* SEE INSTRUCTIONS BEFORE FILLING OUT!

 

 

 

 

 


     
CUSIP NO. 09058V 10 3   13G   Page 7 of 10 Pages

     

1   NAME OF REPORTING PERSON:
I.R.S. IDENTIFICATION NO. OF ABOVE PERSON (ENTITIES ONLY):
   

 

 

BVF Inc.

 

 

2   CHECK THE APPROPRIATE BOX IF A MEMBER OF A GROUP*    
        (a)x
        (b)o

3   SEC USE ONLY    

 

 

 

 

 

4   CITIZENSHIP OR PLACE OF    

 

 

Delaware

 

 

  5   SOLE VOTING POWER
NUMBER     0
OF    
SHARES 6   SHARED VOTING POWER
BENEFICIALLY     9,600
OWNED BY    
EACH 7   SOLE DISPOSITIVE POWER
REPORTING     0
PERSON    
WITH 8   SHARED DISPOSITIVE POWER
      9,600

9   AGGREGATE AMOUNT BENEFICIALLY OWNED BY EACH REPORTING PERSON    

 

 

9,600

 

 

10   CHECK BOX IF THE AGGREGATE AMOUNT IN ROW (9) EXCLUDES CERTAIN SHARES*    

 

 

 

 

o

11   PERCENT OF CLASS REPRESENTED BY AMOUNT IN ROW 9    

 

 

0.05%

 

 

12   TYPE OF REPORTING PERSON*    

 

 

IA, CO

 

 

* SEE INSTRUCTIONS BEFORE FILLING OUT!

 

 

 

 

 


     
CUSIP NO. 09058V 10 3   13G   Page 8 of 10 Pages

     


ITEM 1(a).  NAME OF ISSUER:

      Biocryst Pharmaceuticals Inc. ("Biocryst")


ITEM 1(b).  ADDRESS OF ISSUER'S PRINCIPAL EXECUTIVE OFFICES:

      2190 Parkway Lake Drive
      Birmingham, Alabama 35244

ITEM 2(a).  NAME OF PERSON FILING:

      This Amendment to Schedule 13G (the “Amendment”) is being filed on behalf of the following persons (the "Reporting Persons"):

      (i)
      Biotechnology Value Fund, L.P. ("BVF")
      (ii)
      Biotechnology Value Fund II, L.P. ("BVF2")
      (iii)
      BVF Investments, L.L.C. ("Investments")
      (iv)
      Investment 10, L.L.C. ("ILL10")
      (v)
      BVF Partners L.P. ("Partners")
      (vi)
      BVF Inc. ("BVF Inc.")

       

ITEM 2(b).  ADDRESS OF PRINCIPAL BUSINESS OFFICE:

      The principal business office of the Reporting Persons comprising the group filing this Amendment to Schedule 13G is located at 227 West Monroe Street, Suite 4800, Chicago, Illinois, 60606.

ITEM 2(c).  CITIZENSHIP:

BVF:   a Delaware limited partnership
BVF2:   a Delaware limited partnership
Investments:   a Delaware limited liability company
ILL10:   an Illinois limited liability company
Partners:   a Delaware limited partnership
BVF Inc.:   a Delaware corporation

ITEM 2(d).  TITLE OF CLASS OF SECURITIES:

      This Amendment to Schedule 13G is being filed with respect to the common stock, par value $0.01 per share (the "Common Stock"), of Biocryst. The Reporting Persons' percentage ownership of Common Stock is based on 17,733,583 shares of Common Stock being outstanding.

ITEM 2(e).  CUSIP Number:

      09058V 10 3



         
    CUSIP NO. 09058V 10 3   13G   Page 9 of 10 Pages

         


    ITEM 3.  IF THIS STATEMENT IS FILED PURSUANT TO RULE 13d-1(b), or 13d-2(b) or (c)
                    CHECK WHETHER THE PERSON FILING IS: One of the following

        Not applicable as this Amendment to Schedule 13G is filed pursuant to Rule 13d–1(c).


    ITEM 4.  OWNERSHIP:

        The information in items 1 and 5 through 11 on the cover pages (pp. 2 - 7) on this Amendment to Schedule 13G is hereby incorporated by reference.


    ITEM 5.  OWNERSHIP OF FIVE PERCENT OR LESS OF A CLASS:

        If this statement is being filed to report the fact that as of the date hereof the Reporting Persons have ceased to be the beneficial owner of more than five percent of the class of securities check the following. x


    ITEM 6.  OWNERSHIP OF MORE THAN FIVE PERCENT ON BEHALF OF ANOTHER PERSON:

        BVF shares voting and dispositive power over the shares of the Common Stock it beneficially owns with Partners. BVF2 also shares voting and dispositive power over the shares of the Common Stock it beneficially owns with Partners. Investments also shares voting and dispositive power over the shares of the Common Stock it beneficially owns with Partners. Pursuant to the operating agreement of Investments, Partners is authorized, among other things, to invest the funds of Ziff Asset Management, L.P., the majority member of Investments, in shares of the Common Stock beneficially owned by Investments and to vote and exercise dispositive power over those shares of Common Stock. Partners and BVF Inc. share voting and dispositive power over the shares of Common Stock beneficially owned by BVF, BVF2, Investments and those owned by ILL10, on whose behalf Partners acts as investment manager and, accordingly, Partners and BVF Inc. have beneficial ownership of all of the shares of Common Stock owned by such parties.


    ITEM 7.  IDENTIFICATION AND CLASSIFICATION OF THE SUBSIDIARY WHICH ACQUIRED
                    THE SECURITY BEING REPORTED ON BY THE PARENT HOLDING COMPANY:

        Not applicable.


    ITEM 8.  IDENTIFICATION AND CLASSIFICATION OF MEMBERS OF A GROUP:

        Not applicable.


    ITEM 9.  NOTICE OF DISSOLUTION OF GROUP:

        Not applicable.



           
      CUSIP NO. 09058V 10 3   13G   Page 10 of 10 Pages

           


      ITEM 10. CERTIFICATION

              By signing below I certify that, to the best of my knowledge and belief, the securities referred to above were not acquired and are not held for the purpose of or with the effect of changing or influencing the control of the issuer of the securities and were not acquired and are not held in connection with or as a participant in any transaction having that purpose or effect.

              After reasonable inquiry and to the best of my knowledge and belief, I certify that the information set forth in this statement is true, complete and correct.

      Dated:  December 11, 2003          
                 
          BIOTECHNOLOGY VALUE FUND, L.P.
                 
          By: BVF Partners L.P., its general partner
                 
            By: BVF Inc., its general partner
                 
              By: /s/  MARK N. LAMPERT      
      Mark N. Lampert
      President
                 
          BIOTECHNOLOGY VALUE FUND II, L.P.
                 
          By: BVF Partners L.P., its general partner
                 
            By: BVF Inc., its general partner
                 
              By: /s/  MARK N. LAMPERT      
      Mark N. Lampert
      President
                 
          BVF INVESTMENTS, L.L.C.
                 
          By: BVF Partners L.P., its manager
                 
            By: BVF Inc., its general partner
                 
              By: /s/  MARK N. LAMPERT      
      Mark N. Lampert
      President
         
      INVESTMENT 10, L.L.C.
                 
          By: BVF Partners L.P., its attorney-in-fact
                 
            By: BVF Inc., its general partner
                 
              By: /s/  MARK N. LAMPERT       
      Mark N. Lampert
      President
                 
          BVF PARTNERS L.P.
                 
          By: BVF Inc., its general partner
                 
            By: /s/  MARK N. LAMPERT      
      Mark N. Lampert
      President
                 
          BVF INC.
                 
          By: /s/  MARK N. LAMPERT      
      Mark N. Lampert
      President