SEC Form 3

FORM 3

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 INITIAL STATEMENT OF BENEFICIAL OWNERSHIP OF SECURITIES Filed pursuant to Section 16(a) of the Securities Exchange Act of 1934 or Section 30(h) of the Investment Company Act of 1940

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1. Name and Address of Reporting Person* Biggar Stephen R (Last) (First) (Middle) 2190 PARKWAY LAKE DRIVE (Street) BIRMINGHAM AL 35244- (City) (State) (Zip)	2. Date of Event Requiring Statement (Month/Day/Year) 10/03/2005	3. Issuer Name and Ticker or Trading Symbol BIOCRYST PHARMACEUTICALS INC [ BCRX ]
		4. Relationship of Reporting Person(s) to Issuer (Check all applicable) X Director 10% Owner Officer (give title below) Other (specify below)	5. If Amendment, Date of Original Filed (Month/Day/Year)
			6. Individual or Joint/Group Filing (Check Applicable Line) X Form filed by One Reporting Person Form filed by More than One Reporting Person

Table I - Non-Derivative Securities Beneficially Owned
1. Title of Security (Instr. 4)	2. Amount of Securities Beneficially Owned (Instr. 4)	3. Ownership Form: Direct (D) or Indirect (I) (Instr. 5)	4. Nature of Indirect Beneficial Ownership (Instr. 5)

Table II - Derivative Securities Beneficially Owned (e.g., puts, calls, warrants, options, convertible securities)
1. Title of Derivative Security (Instr. 4)	2. Date Exercisable and Expiration Date (Month/Day/Year)		3. Title and Amount of Securities Underlying Derivative Security (Instr. 4)		4. Conversion or Exercise Price of Derivative Security	5. Ownership Form: Direct (D) or Indirect (I) (Instr. 5)	6. Nature of Indirect Beneficial Ownership (Instr. 5)
	Date Exercisable	Expiration Date	Title	Amount or Number of Shares

Explanation of Responses:

No securities are beneficially owned.

	Michael Richardson by Power of Attorney	10/05/2005
	** Signature of Reporting Person	Date
Reminder: Report on a separate line for each class of securities beneficially owned directly or indirectly.
* If the form is filed by more than one reporting person, see Instruction 5 (b)(v).
** Intentional misstatements or omissions of facts constitute Federal Criminal Violations See 18 U.S.C. 1001 and 15 U.S.C. 78ff(a).
Note: File three copies of this Form, one of which must be manually signed. If space is insufficient, see Instruction 6 for procedure.
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POWER OF ATTORNEY

Know all men by these presents, that the undersigned director whose signature
 appears below hereby constitutes and appoints Michael A. Darwin and Michael
Richardson, and each of them, his true and lawful attorneys-in-fact and
agents, with full power of substitution and resubstitution, for him and in his
 name, place and stead, in the following capacities:

	To execute for and on behalf of the undersigned Forms 3, 4, 5,
Schedule 13D and amendments thereto relating exclusively to BioCryst
Pharmaceuticals in accordance with Sections 13(d) and 16(a)
of the Securities Exchange Act of 1934 and the rules thereunder;

	i)	To do and perform any and all acts for and on behalf of
 the undersigned which may be necessary or desirable to complete the execution
of any such Form 3, 4, 5 or Schedule 13D and the timely filing of such form
with the United States Securities and Exchange Commission and any other
authority; and

	ii)	To take any other action of any type whatsoever in
connection with the foregoing which, in the opinion of such attorneys-in-fact,
 may be of benefit to, in the best interest of, or legally required by, the
undersigned, it being understood that the documents executed by such
attorneys-in-fact on behalf of the undersigned pursuant to this Power of
Attorney shall be in such form and shall contain such terms and conditions
as such attorneys-in-fact may approve in his discretion.

		The undersigned hereby grants to such attorneys-in-fact
 and agents full power and authority to do and perform all and every act and
 thing whatsoever requisite, necessary and proper to be done in the exercise
 of any of the rights and powers herein granted, as fully to all intents and
purposes as the undersigned might or could do if personally present, with full
power of substitution or revocation, hereby ratifying and confirming all that
such attorney-in-fact, or his substitute or substitutes, shall lawfully do or
cause to be done by virtue of this Power of Attorney and the rights and powers
 herein granted.  The undersigned acknowledges that the foregoing
attorneys-in-fact, in serving in such capacity at the request of the
undersigned, is not assuming any of the undersigned's responsibilities to
comply with Sections 13(d) and 16 of the Securities Exchange Act of 1934.

IN WITNESS WHEREOF, the undersigned has executed this
 Power of Attorney as of this 5th day of October, 2005.



	Stephen Biggar