UNITED
STATES
SECURITIES
AND EXCHANGE COMMISSION
Washington,
D.C. 20549
SCHEDULE
13D
Under
the Securities Exchange Act of 1934
(Amendment
No. _1_)
|
BIOCRYST
PHARMACEUTICALS, INC.
|
||||
|
(Name
of Issuer)
|
||||
|
Common
Stock, par value $0.01 per share
|
||||
|
(Title
of Class of Securities)
|
||||
|
09058V-10-3
|
||||
|
(CUSIP
Number)
|
||||
|
Leo
Kirby
667
Madison Avenue, 19th Floor
New
York, NY 10021
(212)
521-2418
|
||||
|
(Name,
Address and Telephone Number of Person Authorized to Receive Notices
and
Communications)
|
||||
|
March
13, 2006
|
||||
|
(Date
of Event which Requires Filing of this Statement)
|
||||
If
the
filing person has previously filed a statement on Schedule 13G to report the
acquisition that is the subject of this Schedule 13D, and is filing this
schedule because of Rule 13d-1(e), 13d-1(f) or 13d-1(g), check the following
box. X
Note:
Schedules filed in paper format shall include a signed original and five copies
of the schedule, including all exhibits. See Rule 13d-7 for other parties to
whom copies are to be sent.
*The
remainder of this cover page shall be filled out for a reporting person’s
initial filing on this form with respect to the subject class of securities,
and
for any subsequent amendment containing information which would alter
disclosures provided in a prior cover page.
The
information required on the remainder of this cover page shall not be deemed
to
be “filed” for the purpose of Section 18 of the Securities Exchange Act of 1934
(the “Act”) or otherwise subject to the liabilities of that section of the Act
but shall be subject to all other provisions of the Act (however, see the
Notes).
Page
1 of
11
SCHEDULE
13D
|
CUSIP
No. 09058V-10-3
|
Page
2
of
11 Pages
|
|
1
|
NAMES
OF REPORTING PERSONS I.R.S. IDENTIFICATION NOS. OF ABOVE
PERSONS
Julian
C. Baker
|
||||
|
2
|
CHECK
THE APPROPRIATE BOX IF A MEMBER OF A GROUP (See
Instructions)
|
(a)
X
(b)
|
|||
|
3
|
SEC
USE ONLY
|
||||
|
4
|
SOURCE
OF FUNDS (See Instructions)
WC
|
||||
|
5
|
CHECK
BOX IF DISCLOSURE OF LEGAL PROCEEDINGS IS REQUIRED PURSUANT TO ITEMS
2(d)
OR 2(e)
|
o | |||
|
6
|
CITIZENSHIP
OR PLACE OF ORGANIZATION
United
States
|
||||
|
NUMBER
OF
SHARES
BENEFICIALLY
OWNED
BY
EACH
REPORTING
PERSON
WITH
|
7
|
SOLE
VOTING POWER
0
|
|||
|
8
|
SHARED
VOTING POWER
1,774,838
|
||||
|
9
|
SOLE
DISPOSITIVE POWER
0
|
||||
|
10
|
SHARED
DISPOSITIVE POWER
1,774,838
|
||||
|
11
|
AGGREGATE
AMOUNT BENEFICIALLY OWNED BY EACH REPORTING PERSON
1,774,838
|
||||
|
12
|
CHECK
BOX IF THE AGGREGATE AMOUNT IN ROW (11) EXCLUDES CERTAIN SHARES (See
Instructions)
|
o | |||
|
13
|
PERCENT
OF CLASS REPRESENTED BY AMOUNT IN ROW (11)
6.1%
|
||||
|
14
|
TYPE
OF REPORTING PERSON (See Instructions)
IN
|
||||
Page
2 of
11
SCHEDULE
13D
|
CUSIP
No. 09058V-10-3
|
Page 3 of
11 Pages
|
|
1
|
NAMES
OF REPORTING PERSONS I.R.S. IDENTIFICATION NOS. OF ABOVE
PERSONS
Felix
J. Baker
|
||||
|
2
|
CHECK
THE APPROPRIATE BOX IF A MEMBER OF A GROUP (See Instructions)
|
(a) X
(b)
|
|||
|
3
|
SEC
USE ONLY
|
||||
|
4
|
SOURCE
OF FUNDS (See Instructions)
WC
|
||||
|
5
|
CHECK
BOX IF DISCLOSURE OF LEGAL PROCEEDINGS IS REQUIRED PURSUANT TO ITEMS
2(d)
OR 2(e)
|
o | |||
|
6
|
CITIZENSHIP
OR PLACE OF ORGANIZATION
United
States
|
||||
|
NUMBER
OF
SHARES
BENEFICIALLY
OWNED
BY
EACH
REPORTING
PERSON
WITH
|
7
|
SOLE
VOTING POWER
0
|
|||
|
8
|
SHARED
VOTING POWER
1,774,838
|
||||
|
9
|
SOLE
DISPOSITIVE POWER
0
|
||||
|
10
|
SHARED
DISPOSITIVE POWER
1,774,838
|
||||
|
11
|
AGGREGATE
AMOUNT BENEFICIALLY OWNED BY EACH REPORTING PERSON
1,774,838
|
||||
|
12
|
CHECK
BOX IF THE AGGREGATE AMOUNT IN ROW (11) EXCLUDES CERTAIN SHARES (See
Instructions)
|
o | |||
|
13
|
PERCENT
OF CLASS REPRESENTED BY AMOUNT IN ROW (11)
6.1%
|
||||
|
14
|
TYPE
OF REPORTING PERSON (See Instructions)
IN
|
||||
This
Amendment No.1 to Schedule 13D is being filed by Julian C. Baker and Felix
J.
Baker (the “Reporting Persons”) to supplement the statements on Schedule 13D
previously filed by them, as heretofore amended. Except as supplemented herein,
such statements, as heretofore amended and supplemented, remain in full force
and effect.
Page
3 of
11
Item
5. Interest
in Securities of the Issuer.
Set
forth
in the table below is the aggregate number of shares of Common Stock
beneficially owned as of the date hereof by each of the following, together
with
the percentage of outstanding shares of Common Stock that such number represents
based upon 28,980,228
shares
outstanding as reported on the company’s SEC Form 10K filed on March 3,
2006
|
Name
|
Number
of Shares
|
Percent
of Class
Outstanding
|
|
Baker
Bros Investments, L.P.
|
53,960
|
0.2%
|
|
Baker
Bros. Investments II, L.P.
|
51,998
|
0.2%
|
|
Baker/Tisch
Investments, L.P.
|
43,907
|
0.2%
|
|
Baker
Biotech Fund I, L.P.
|
532,590
|
1.8%
|
|
Baker
Biotech Fund II, L.P.
|
486,752
|
1.7%
|
|
Baker
Biotech Fund II (Z), L.P.
|
67,285
|
0.2%
|
|
Baker
Biotech Fund III, L.P.
|
422,168
|
1.5%
|
|
Baker
Biotech Fund III (Z), L.P.
|
82,529
|
0.3%
|
|
14159,
L.P.
|
33,649
|
0.1%
|
|
Total
|
1,774,838
|
6.1%
|
By
virtue
of their ownership of entities that have the power to control the investment
decisions of the limited partnerships listed in the table above, Julian C.
Baker
and Felix J. Baker may each be deemed to be beneficial owners of shares owned
by
such entities and may be deemed to have shared power to vote or direct the
vote
of and shared power to dispose or direct the disposition of such securities.
The
following transactions in Common Stock were effected by the entities noted
below
since the most recent filing on schedule 13D. None of the reporting Persons
has
effected any other transactions in Common Stock since the most recent filing
on
schedule 13D.
Page
4 of
11
|
Name
|
Date
|
Number
of Shares
|
Transaction
|
Price/Share
|
Aggregate
Amount
|
|||||||||||
|
Baker
Tisch Investments, LP
|
2/28/2006
|
3,754
|
Sale
|
20.19
|
$
|
75,793
|
||||||||||
|
Baker
Bros. Investments, LP
|
2/28/2006
|
4,613
|
Sale
|
20.19
|
$
|
93,136
|
||||||||||
|
Baker
Bros. Investments II, LP
|
2/28/2006
|
4,444
|
Sale
|
20.19
|
$
|
89,724
|
||||||||||
|
Baker
Biotech Fund I, LP
|
2/28/2006
|
45,525
|
Sale
|
20.19
|
$
|
919,149
|
||||||||||
|
Baker
Biotech Fund II, LP
|
2/28/2006
|
41,606
|
Sale
|
20.19
|
$
|
840,025
|
||||||||||
|
Baker
Biotech Fund II (Z), LP
|
2/28/2006
|
5,751
|
Sale
|
20.19
|
$
|
116,113
|
||||||||||
|
Baker
Biotech Fund III, LP
|
2/28/2006
|
36,086
|
Sale
|
20.19
|
$
|
728,576
|
||||||||||
|
Baker
Biotech Fund III (Z), LP
|
2/28/2006
|
7,054
|
Sale
|
20.19
|
$
|
142,420
|
||||||||||
|
14159,
LP
|
2/28/2006
|
2,876
|
Sale
|
20.19
|
$
|
58,066
|
||||||||||
|
Name
|
Date
|
Number
of Shares
|
Transaction
|
Price/Share
|
Aggregate
Amount
|
|||||||||||
|
Baker
Tisch Investments, LP
|
2/28/2006
|
356
|
Sale
|
21.15
|
$
|
7,529
|
||||||||||
|
Baker
Bros. Investments, LP
|
2/28/2006
|
438
|
Sale
|
21.15
|
$
|
9,264
|
||||||||||
|
Baker
Bros. Investments II, LP
|
2/28/2006
|
422
|
Sale
|
21.15
|
$
|
8,925
|
||||||||||
|
Baker
Biotech Fund I, LP
|
2/28/2006
|
4,321
|
Sale
|
21.15
|
$
|
91,389
|
||||||||||
|
Baker
Biotech Fund II, LP
|
2/28/2006
|
3,949
|
Sale
|
21.15
|
$
|
83,521
|
||||||||||
|
Baker
Biotech Fund II (Z), LP
|
2/28/2006
|
546
|
Sale
|
21.15
|
$
|
11,548
|
||||||||||
|
Baker
Biotech Fund III, LP
|
2/28/2006
|
3,425
|
Sale
|
21.15
|
$
|
72,439
|
||||||||||
|
Baker
Biotech Fund III (Z), LP
|
2/28/2006
|
670
|
Sale
|
21.15
|
$
|
14,171
|
||||||||||
|
14159,
LP
|
2/28/2006
|
273
|
Sale
|
21.15
|
$
|
5,774
|
||||||||||
|
|
|
|||||||||||||||
|
Baker
Tisch Investments, LP
|
3/1/2006
|
384
|
Sale
|
20.3
|
$
|
7,795
|
||||||||||
|
Baker
Bros. Investments, LP
|
3/1/2006
|
472
|
Sale
|
20.3
|
$
|
9,582
|
||||||||||
|
Baker
Bros. Investments II, LP
|
3/1/2006
|
455
|
Sale
|
20.3
|
$
|
9,237
|
||||||||||
|
Baker
Biotech Fund I, LP
|
3/1/2006
|
4,661
|
Sale
|
20.3
|
$
|
94,618
|
||||||||||
|
Baker
Biotech Fund II, LP
|
3/1/2006
|
4,259
|
Sale
|
20.3
|
$
|
86,458
|
||||||||||
|
Baker
Biotech Fund II (Z), LP
|
3/1/2006
|
589
|
Sale
|
20.3
|
$
|
11,957
|
||||||||||
|
Baker
Biotech Fund III, LP
|
3/1/2006
|
3,694
|
Sale
|
20.3
|
$
|
74,988
|
||||||||||
|
Baker
Biotech Fund III (Z), LP
|
3/1/2006
|
722
|
Sale
|
20.3
|
$
|
14,657
|
||||||||||
|
14159,
LP
|
3/1/2006
|
295
|
Sale
|
20.3
|
$
|
5,989
|
||||||||||
Page
5 of
11
|
Name
|
Date
|
Number
of Shares
|
Transaction
|
Price/Share
|
Aggregate
Amount
|
|||||||||||
|
Baker
Tisch Investments, LP
|
3/2/2006
|
618
|
Sale
|
20.57
|
$
|
12,712
|
||||||||||
|
Baker
Bros. Investments, LP
|
3/2/2006
|
760
|
Sale
|
20.57
|
$
|
15,633
|
||||||||||
|
Baker
Bros. Investments II, LP
|
3/2/2006
|
732
|
Sale
|
20.57
|
$
|
15,057
|
||||||||||
|
Baker
Biotech Fund I, LP
|
3/2/2006
|
7,502
|
Sale
|
20.57
|
$
|
154,316
|
||||||||||
|
Baker
Biotech Fund II, LP
|
3/2/2006
|
6,856
|
Sale
|
20.57
|
$
|
141,028
|
||||||||||
|
Baker
Biotech Fund II (Z), LP
|
3/2/2006
|
948
|
Sale
|
20.57
|
$
|
19,500
|
||||||||||
|
Baker
Biotech Fund III, LP
|
3/2/2006
|
5,947
|
Sale
|
20.57
|
$
|
122,330
|
||||||||||
|
Baker
Biotech Fund III (Z), LP
|
3/2/2006
|
1,162
|
Sale
|
20.57
|
$
|
23,902
|
||||||||||
|
14159,
LP
|
3/2/2006
|
475
|
Sale
|
20.57
|
$
|
9,771
|
||||||||||
|
|
|
|||||||||||||||
|
Baker
Tisch Investments, LP
|
3/3/2006
|
665
|
Sale
|
20.79
|
$
|
13,825
|
||||||||||
|
Baker
Bros. Investments, LP
|
3/3/2006
|
818
|
Sale
|
20.79
|
$
|
17,006
|
||||||||||
|
Baker
Bros. Investments II, LP
|
3/3/2006
|
788
|
Sale
|
20.79
|
$
|
16,383
|
||||||||||
|
Baker
Biotech Fund I, LP
|
3/3/2006
|
8,076
|
Sale
|
20.79
|
$
|
167,900
|
||||||||||
|
Baker
Biotech Fund II, LP
|
3/3/2006
|
7,381
|
Sale
|
20.79
|
$
|
153,451
|
||||||||||
|
Baker
Biotech Fund II (Z), LP
|
3/3/2006
|
1,020
|
Sale
|
20.79
|
$
|
21,206
|
||||||||||
|
Baker
Biotech Fund III, LP
|
3/3/2006
|
6,401
|
Sale
|
20.79
|
$
|
133,077
|
||||||||||
|
Baker
Biotech Fund III (Z), LP
|
3/3/2006
|
1,251
|
Sale
|
20.79
|
$
|
26,008
|
||||||||||
|
14159,
LP
|
3/3/2006
|
512
|
Sale
|
20.79
|
$
|
10,644
|
||||||||||
|
|
|
|||||||||||||||
|
Baker
Tisch Investments, LP
|
3/8/2006
|
131
|
Sale
|
19.04
|
$
|
2,494
|
||||||||||
|
Baker
Bros. Investments, LP
|
3/8/2006
|
161
|
Sale
|
19.04
|
$
|
3,065
|
||||||||||
|
Baker
Bros. Investments II, LP
|
3/8/2006
|
155
|
Sale
|
19.04
|
$
|
2,951
|
||||||||||
|
Baker
Biotech Fund I, LP
|
3/8/2006
|
1,588
|
Sale
|
19.04
|
$
|
30,235
|
||||||||||
|
Baker
Biotech Fund II, LP
|
3/8/2006
|
1,451
|
Sale
|
19.04
|
$
|
27,627
|
||||||||||
|
Baker
Biotech Fund II (Z), LP
|
3/8/2006
|
201
|
Sale
|
19.04
|
$
|
3,827
|
||||||||||
|
Baker
Biotech Fund III, LP
|
3/8/2006
|
1,259
|
Sale
|
19.04
|
$
|
23,971
|
||||||||||
|
Baker
Biotech Fund III (Z), LP
|
3/8/2006
|
246
|
Sale
|
19.04
|
$
|
4,684
|
||||||||||
|
14159,
LP
|
3/8/2006
|
99
|
Sale
|
19.04
|
$
|
1,885
|
||||||||||
Page
6 of
11
|
Name
|
Date
|
Number
of Shares
|
Transaction
|
Price/Share
|
Aggregate
Amount
|
|||||||||||
|
Baker
Tisch Investments, LP
|
3/9/2006
|
666
|
Sale
|
20.15
|
$
|
13,420
|
||||||||||
|
Baker
Bros. Investments, LP
|
3/9/2006
|
818
|
Sale
|
20.15
|
$
|
16,483
|
||||||||||
|
Baker
Bros. Investments II, LP
|
3/9/2006
|
788
|
Sale
|
20.15
|
$
|
15,878
|
||||||||||
|
Baker
Biotech Fund I, LP
|
3/9/2006
|
8,072
|
Sale
|
20.15
|
$
|
162,650
|
||||||||||
|
Baker
Biotech Fund II, LP
|
3/9/2006
|
7,377
|
Sale
|
20.15
|
$
|
148,647
|
||||||||||
|
Baker
Biotech Fund II (Z), LP
|
3/9/2006
|
1,020
|
Sale
|
20.15
|
$
|
20,553
|
||||||||||
|
Baker
Biotech Fund III, LP
|
3/9/2006
|
6,399
|
Sale
|
20.15
|
$
|
128,940
|
||||||||||
|
Baker
Biotech Fund III (Z), LP
|
3/9/2006
|
1,251
|
Sale
|
20.15
|
$
|
25,208
|
||||||||||
|
14159,
LP
|
3/9/2006
|
509
|
Sale
|
20.15
|
$
|
10,256
|
||||||||||
|
|
||||||||||||||||
|
Baker
Tisch Investments, LP
|
3/13/2006
|
2,022
|
Sale
|
19.73
|
$
|
39,894
|
||||||||||
|
Baker
Bros. Investments, LP
|
3/13/2006
|
2,483
|
Sale
|
19.73
|
$
|
48,990
|
||||||||||
|
Baker
Bros. Investments II, LP
|
3/13/2006
|
2,393
|
Sale
|
19.73
|
$
|
47,214
|
||||||||||
|
Baker
Biotech Fund I, LP
|
3/13/2006
|
24,509
|
Sale
|
19.73
|
$
|
483,562
|
||||||||||
|
Baker
Biotech Fund II, LP
|
3/13/2006
|
22,401
|
Sale
|
19.73
|
$
|
441,972
|
||||||||||
|
Baker
Biotech Fund II (Z), LP
|
3/13/2006
|
3,097
|
Sale
|
19.73
|
$
|
61,104
|
||||||||||
|
Baker
Biotech Fund III, LP
|
3/13/2006
|
19,429
|
Sale
|
19.73
|
$
|
383,334
|
||||||||||
|
Baker
Biotech Fund III (Z), LP
|
3/13/2006
|
3,798
|
Sale
|
19.73
|
$
|
74,935
|
||||||||||
|
14159,
LP
|
3/13/2006
|
1,546
|
Sale
|
19.73
|
$
|
30,503
|
||||||||||
|
|
|
|||||||||||||||
|
|
|
|||||||||||||||
|
Baker
Tisch Investments, LP
|
3/13/2006
|
2,155
|
Sale
|
19.69
|
$
|
42,431
|
||||||||||
|
Baker
Bros. Investments, LP
|
3/13/2006
|
2,648
|
Sale
|
19.69
|
$
|
52,139
|
||||||||||
|
Baker
Bros. Investments II, LP
|
3/13/2006
|
2,552
|
Sale
|
19.69
|
$
|
50,249
|
||||||||||
|
Baker
Biotech Fund I, LP
|
3/13/2006
|
26,136
|
Sale
|
19.69
|
$
|
514,617
|
||||||||||
|
Baker
Biotech Fund II, LP
|
3/13/2006
|
23,887
|
Sale
|
19.69
|
$
|
470,335
|
||||||||||
|
Baker
Biotech Fund II (Z), LP
|
3/13/2006
|
3,302
|
Sale
|
19.69
|
$
|
65,016
|
||||||||||
|
Baker
Biotech Fund III, LP
|
3/13/2006
|
20,718
|
Sale
|
19.69
|
$
|
407,937
|
||||||||||
|
Baker
Biotech Fund III (Z), LP
|
3/13/2006
|
4,050
|
Sale
|
19.69
|
$
|
79,745
|
||||||||||
|
14159,
LP
|
3/13/2006
|
1,652
|
Sale
|
19.69
|
$
|
32,528
|
||||||||||
|
|
||||||||||||||||
Page
7 of
11
|
Name
|
Date
|
Number
of Shares
|
Transaction
|
Price/Share
|
Aggregate
Amount
|
|||||||||||
|
Baker
Tisch Investments, LP
|
3/14/2006
|
668
|
Sale
|
19.54
|
$
|
13,053
|
||||||||||
|
Baker
Bros. Investments, LP
|
3/14/2006
|
821
|
Sale
|
19.54
|
$
|
16,042
|
||||||||||
|
Baker
Bros. Investments II, LP
|
3/14/2006
|
791
|
Sale
|
19.54
|
$
|
15,456
|
||||||||||
|
Baker
Biotech Fund I, LP
|
3/14/2006
|
8,102
|
Sale
|
19.54
|
$
|
158,313
|
||||||||||
|
Baker
Biotech Fund II, LP
|
3/14/2006
|
7,404
|
Sale
|
19.54
|
$
|
144,674
|
||||||||||
|
Baker
Biotech Fund II (Z), LP
|
3/14/2006
|
1,024
|
Sale
|
19.54
|
$
|
20,009
|
||||||||||
|
Baker
Biotech Fund III, LP
|
3/14/2006
|
6,422
|
Sale
|
19.54
|
$
|
125,486
|
||||||||||
|
Baker
Biotech Fund III (Z), LP
|
3/14/2006
|
1,255
|
Sale
|
19.54
|
$
|
24,523
|
||||||||||
|
14159,
LP
|
3/14/2006
|
511
|
Sale
|
19.54
|
$
|
9,985
|
||||||||||
|
|
|
|||||||||||||||
|
Baker
Tisch Investments, LP
|
3/14/2006
|
549
|
Sale
|
19.5
|
$
|
10,706
|
||||||||||
|
Baker
Bros. Investments, LP
|
3/14/2006
|
674
|
Sale
|
19.5
|
$
|
13,143
|
||||||||||
|
Baker
Bros. Investments II, LP
|
3/14/2006
|
649
|
Sale
|
19.5
|
$
|
12,656
|
||||||||||
|
Baker
Biotech Fund I, LP
|
3/14/2006
|
6,650
|
Sale
|
19.5
|
$
|
129,673
|
||||||||||
|
Baker
Biotech Fund II, LP
|
3/14/2006
|
6,077
|
Sale
|
19.5
|
$
|
118,502
|
||||||||||
|
Baker
Biotech Fund II (Z), LP
|
3/14/2006
|
840
|
Sale
|
19.5
|
$
|
16,380
|
||||||||||
|
Baker
Biotech Fund III, LP
|
3/14/2006
|
5,271
|
Sale
|
19.5
|
$
|
102,785
|
||||||||||
|
Baker
Biotech Fund III (Z), LP
|
3/14/2006
|
1,030
|
Sale
|
19.5
|
$
|
20,085
|
||||||||||
|
14159,
LP
|
3/14/2006
|
420
|
Sale
|
19.5
|
$
|
8,190
|
||||||||||
|
|
|
|||||||||||||||
|
Baker
Tisch Investments, LP
|
3/14/2006
|
1,187
|
Sale
|
19.49
|
$
|
23,135
|
||||||||||
|
Baker
Bros. Investments, LP
|
3/14/2006
|
1,459
|
Sale
|
19.49
|
$
|
28,436
|
||||||||||
|
Baker
Bros. Investments II, LP
|
3/14/2006
|
1,405
|
Sale
|
19.49
|
$
|
27,383
|
||||||||||
|
Baker
Biotech Fund I, LP
|
3/14/2006
|
14,393
|
Sale
|
19.49
|
$
|
280,519
|
||||||||||
|
Baker
Biotech Fund II, LP
|
3/14/2006
|
13,155
|
Sale
|
19.49
|
$
|
256,391
|
||||||||||
|
Baker
Biotech Fund II (Z), LP
|
3/14/2006
|
1,818
|
Sale
|
19.49
|
$
|
35,433
|
||||||||||
|
Baker
Biotech Fund III, LP
|
3/14/2006
|
11,409
|
Sale
|
19.49
|
$
|
222,361
|
||||||||||
|
Baker
Biotech Fund III (Z), LP
|
3/14/2006
|
2,230
|
Sale
|
19.49
|
$
|
43,463
|
||||||||||
|
14159,
LP
|
3/14/2006
|
909
|
Sale
|
19.49
|
$
|
17,716
|
||||||||||
Page
8 of
11
|
Name
|
Date
|
Number
of Shares
|
Transaction
|
Price/Share
|
Aggregate
Amount
|
|||||||||||
|
Baker
Tisch Investments, LP
|
3/15/2006
|
307
|
Sale
|
19.06
|
$
|
5,851
|
||||||||||
|
Baker
Bros. Investments, LP
|
3/15/2006
|
377
|
Sale
|
19.06
|
$
|
7,186
|
||||||||||
|
Baker
Bros. Investments II, LP
|
3/15/2006
|
363
|
Sale
|
19.06
|
$
|
6,919
|
||||||||||
|
Baker
Biotech Fund I, LP
|
3/15/2006
|
3,721
|
Sale
|
19.06
|
$
|
70,922
|
||||||||||
|
Baker
Biotech Fund II, LP
|
3/15/2006
|
3,401
|
Sale
|
19.06
|
$
|
64,823
|
||||||||||
|
Baker
Biotech Fund II (Z), LP
|
3/15/2006
|
470
|
Sale
|
19.06
|
$
|
8,958
|
||||||||||
|
Baker
Biotech Fund III, LP
|
3/15/2006
|
2,949
|
Sale
|
19.06
|
$
|
56,208
|
||||||||||
|
Baker
Biotech Fund III (Z), LP
|
3/15/2006
|
577
|
Sale
|
19.06
|
$
|
10,998
|
||||||||||
|
14159,
LP
|
3/15/2006
|
235
|
Sale
|
19.06
|
$
|
4,479
|
||||||||||
|
|
|
|||||||||||||||
|
Baker
Tisch Investments, LP
|
3/15/2006
|
388
|
Sale
|
19.25
|
$
|
7,469
|
||||||||||
|
Baker
Bros. Investments, LP
|
3/15/2006
|
475
|
Sale
|
19.25
|
$
|
9,144
|
||||||||||
|
Baker
Bros. Investments II, LP
|
3/15/2006
|
457
|
Sale
|
19.25
|
$
|
8,797
|
||||||||||
|
Baker
Biotech Fund I, LP
|
3/15/2006
|
4,697
|
Sale
|
19.25
|
$
|
90,417
|
||||||||||
|
Baker
Biotech Fund II, LP
|
3/15/2006
|
4,293
|
Sale
|
19.25
|
$
|
82,640
|
||||||||||
|
Baker
Biotech Fund II (Z), LP
|
3/15/2006
|
593
|
Sale
|
19.25
|
$
|
11,415
|
||||||||||
|
Baker
Biotech Fund III, LP
|
3/15/2006
|
3,723
|
Sale
|
19.25
|
$
|
71,668
|
||||||||||
|
Baker
Biotech Fund III (Z), LP
|
3/15/2006
|
729
|
Sale
|
19.25
|
$
|
14,033
|
||||||||||
|
14159,
LP
|
3/15/2006
|
299
|
Sale
|
19.25
|
$
|
5,756
|
||||||||||
|
|
|
|||||||||||||||
|
Baker
Tisch Investments, LP
|
3/15/2006
|
236
|
Sale
|
19.23
|
$
|
4,538
|
||||||||||
|
Baker
Bros. Investments, LP
|
3/15/2006
|
288
|
Sale
|
19.23
|
$
|
5,538
|
||||||||||
|
Baker
Bros. Investments II, LP
|
3/15/2006
|
279
|
Sale
|
19.23
|
$
|
5,365
|
||||||||||
|
Baker
Biotech Fund I, LP
|
3/15/2006
|
2,851
|
Sale
|
19.23
|
$
|
54,824
|
||||||||||
|
Baker
Biotech Fund II, LP
|
3/15/2006
|
2,605
|
Sale
|
19.23
|
$
|
50,094
|
||||||||||
|
Baker
Biotech Fund II (Z), LP
|
3/15/2006
|
361
|
Sale
|
19.23
|
$
|
6,942
|
||||||||||
|
Baker
Biotech Fund III, LP
|
3/15/2006
|
2,260
|
Sale
|
19.23
|
$
|
43,460
|
||||||||||
|
Baker
Biotech Fund III (Z), LP
|
3/15/2006
|
443
|
Sale
|
19.23
|
$
|
8,519
|
||||||||||
|
14159,
LP
|
3/15/2006
|
177
|
Sale
|
19.23
|
$
|
3,404
|
||||||||||
Item
7. Material
to Be Filed as Exhibits.
Exhibit
1. Agreement
regarding the joint filing of this statement.
Page
9 of
11
SIGNATURE
After
reasonable inquiry and to the best of my knowledge and belief, I certify that
the information set forth in this statement is true, complete and
correct.
March
15, 2006
| By: | /s/ Julian C. Baker | |
|
Julian C. Baker |
||
| By: | /s/ Felix J. Baker | |
|
Felix J. Baker |
||
Page
10
of 11
EXHIBIT
1
AGREEMENT
In
accordance with Rule 13d-1(k)(1) under the Securities Exchange Act of 1934,
as
amended, the undersigned hereby agree that this Statement on Schedule 13D
relating to the Common Stock, $0.01 par value, of Biocryst Pharmaceuticals,
Inc.
is being filed with the Securities and Exchange Commission on behalf of each
of
them.
March
15, 2006
| By: | /s/ Julian C. Baker | |
|
Julian C. Baker |
||
| By: | /s/ Felix J. Baker | |
|
Felix J. Baker |
||
Page
11
of 11