UNITED STATES
SECURITIES AND EXCHANGE COMMISSION
Washington, D.C. 20549

FORM 8-K

CURRENT REPORT
Pursuant to Section 13 or 15(d) of the Securities Exchange Act of 1934

Date of Report (Date of earliest event reported): August 18, 2008

BioCryst Pharmaceuticals, Inc.
(Exact name of registrant as specified in its charter)

DELAWARE		000-23186		62-1413174
(State or other Jurisdiction of Incorporation)		(Commission File Number)		(IRS Employer Identification No.)

2190 Parkway Lake Drive, Birmingham, Alabama		35244
(Address of Principal Executive Offices)		(Zip Code)

Registrant’s telephone number, including area code: (205) 444-4600

NOT APPLICABLE

(Former name or former address if changed since last report.)

Check the appropriate box below if the Form 8-K filing is intended to simultaneously satisfy the filing obligation of the registrant under any of the following provisions:

o Written communications pursuant to Rule 425 under the Securities Act (17 CFR 230.425)

o Soliciting material pursuant to Rule 14a-12 under the Exchange Act (17 CFR 240.14a-12)

o Pre-commencement communications pursuant to Rule 14d-2(b) under the Exchange Act (17 CFR 240.14d-2(b))

o Pre-commencement communications pursuant to Rule 13e-4(c) under the Exchange Act (17 CFR 240.13e-4(c))

Exhibit
Number		Description
10.1		Amendment of Solicitation/Modification of Contract.

				BioCryst Pharmaceuticals, Inc.
Date:		November 7, 2008		By:		/s/ Michael A. Darwin
				Name:		Michael A. Darwin
				Title:		Vice President Finance

Exhibit
Number		Description
10.1		Amendment of Solicitation/Modification of Contract.

AMENDMENT OF SOLICITATION/MODIFICATION OF CONTRACT

1. CONTRACT ID CODE

PAGE OF PAGES

1

1

2. AMENDMENT/MODIFICATION NO:

3. EFFECTIVE DATE

4. REQUISITION/PURC

5. PROJECT NO. (If applicable)

Six (6)

See block 16C

N/A

N/A

6. ISSUED BY

CODE

7. ADMINISTERED BY (If other then Item 6)

CODE

Office of Preparedness and Response

Biomedical Advanced Research and Development Authority

U.S. Department of Health and Human Services

330, Independence Avenue, SW Room G640

Washington, DC 20201

8. NAME AND ADDRESS OF CONTRACTOR (No., street, county, State and ZIP Code)								9A. AMENDMENT OF SOLICITATION NO.
BioCryst Pharmaceuticals, Inc.								9B. DATED (SEE ITEM 11)
2190 Parkway Lake Drive
Birmingham, AL 35244
DUNS 61-819-4609
TIN 62-1413174								10A. MODIFICATION OF CONTRACT/ORDER            HHSO100200700032C
CODE			FACILITY CODE			X		10B. DATED (SEE ITEM 13) 01-03-07
		11. THIS ITEM ONLY APPLIES TO AMENDMENTS OF SOLICITATIONS

~ The above numbered solicitation is amended as set forth in Item 14. The hour and date specified for receipt of Offers ~ is extended, ~ is not extended.

Offers must acknowledge receipt of this amendment prior to the hour and date specified in the solicitation or as amended, by one of the following methods: (a) By completing Items 8 and 15, and returning                      copies of the amendment; (b) By acknowledging receipt of this amendment on each copy of the offer submitted; or (c) By separate letter or telegram which Includes a reference to the solicitation and amendment numbers. FAILURE OF YOUR ACKNOWLEDGEMENT TO BE RECEIVED AT THE PLACE DESIGNATED FOR THE RECEIPT OF OFFERS PRIOR TO THE HOUR AND DATE SPECIFIED MAY RESULT IN REJECTION OF YOUR OFFER. If by virtue of this amendment, you desire to change an offer already submitted, such change may be made by telegram or letter, provided each telegram or letter makes reference to the solicitation and this amendment, and is received prior to the opening hour and date specified.

12. ACCOUNTING AND APPROPRIATION DATA (If required)

SOCC:		DOC#		TIN#		LOC#		CAN#

13. THIS ITEM APPLIES ONLY TO MODIFICATIONS OF CONTRACTS/ORDERS; IT MODIFIES THE CONTRACT/ORDER NO. AS DESCRIBED IN ITEM 14.

 

		A.		THIS CHANGE ORDER IS ISSUED PURSUANT TO: (Specify authority) THE CHANGES SET FORTH IN ITEM 14 ARE MADE IN THE CONTRACT ORDER NO. IN ITEM 10A.
		B.		THE ABOVE NUMBERED CONTRACT/ORDER IS MODIFIED TO REFLECT THE ADMINISTRATIVE CHANGES (such as changes in paying office, appropriation date, etc.) SET FORTH IN ITEM 14, PURSUANT TO THE AUTHORITY OF FAR 43.103(b).
X		C.		THIS SUPPLEMENTAL AGREEMENT IS ENTERED INTO PURSUANT TO AUTHORITY OF: FAR 1.602-1, FAR 52.242-15 Stop-Work Order
		D.		OTHER (Specify type of modification and authority)

E. IMPORTANT: Contractor o is not, þ is required to sign this document and return 2 copies to the issuing office.

 

14. DESCRIPTION OF AMENDMENT/MODIFICATION (Organized by UCF section headings, including solicitation/contract subject matter where feasible)

PURPOSE: The purpose of this modification is to:

1.

Extend the period of the Stop-Work Order for an additional 90 days until November 17, 2008.

The total contract amount remains unchanged. ($102,661,429)

The contract completion date remains unchanged. (December 31, 2010)

Except as provided herein, all terms and conditions referenced in item 9A or 10A, as heretofore changed, remains full force and effect.

15A. NAME AND TITLE OF SIGNER (Type or print)		16A. NAME AND TITLE OF CONTRACTING OFFICER (Type or print)
Michael A. Darwin, VP Finance		Schuyler T. Eldridge

15B. CONTRACTOR/OFFEROR		15C. DATE SIGNED		16B. UNITED STATES OF AMERICA				16C. DATE SIGNED
/s/ Michael A. Darwin   (Signature of person authorized to sign)		8/18/08		BY		/s/ Schuyler T. Eldridge   (Signature of Contracting Officer)		8/18/08

NSN 7540-01-152-8070		OMB No. 0990—0115		STANDARD FORM 30 (REV. 10-83)