0000882796 2022-01-01 2022-12-31 0000882796 2020-01-01 2020-12-31 0000882796 2021-01-01 2021-12-31 0000882796 bcrx:YearOverYearChangeInFairValueFromTheEndOfThePriorYearThroughTheVestingDateOfEquityAwardsGrantedInPriorYearsThatVestedInTheYearMember ecd:PeoMember 2020-01-01 2020-12-31 0000882796 bcrx:StockAwardsAndOptionAwardsReportedInSummaryCompensationTableMember ecd:PeoMember 2022-01-01 2022-12-31 0000882796 bcrx:StockAwardsAndOptionAwardsReportedInSummaryCompensationTableMember ecd:PeoMember 2020-01-01 2020-12-31 0000882796 bcrx:YearOverYearChangeInFairValueFromTheEndOfThePriorYearThroughTheVestingDateOfEquityAwardsGrantedInPriorYearsThatVestedInTheYearMember ecd:PeoMember 2022-01-01 2022-12-31 0000882796 bcrx:YearOverYearChangeInFairValueFromTheEndOfThePriorYearThroughTheVestingDateOfEquityAwardsGrantedInPriorYearsThatVestedInTheYearMember ecd:PeoMember 2021-01-01 2021-12-31 0000882796 bcrx:StockAwardsAndOptionAwardsReportedInSummaryCompensationTableMember ecd:PeoMember 2021-01-01 2021-12-31 0000882796 bcrx:YearEndFairValueOfOutstandingAndUnvestedEquityAwardsGrantedInTheYearMember ecd:PeoMember 2020-01-01 2020-12-31 0000882796 bcrx:YearEndFairValueOfOutstandingAndUnvestedEquityAwardsGrantedInTheYearMember ecd:PeoMember 2022-01-01 2022-12-31 0000882796 bcrx:YearEndFairValueOfOutstandingAndUnvestedEquityAwardsGrantedInTheYearMember ecd:PeoMember 2021-01-01 2021-12-31 0000882796 bcrx:YearOverYearChangeInFairValueOfOutstandingAndUnvestedEquityAwardsGrantedInPriorYearsMember ecd:PeoMember 2020-01-01 2020-12-31 0000882796 bcrx:YearOverYearChangeInFairValueOfOutstandingAndUnvestedEquityAwardsGrantedInPriorYearsMember ecd:PeoMember 2021-01-01 2021-12-31 0000882796 bcrx:YearOverYearChangeInFairValueOfOutstandingAndUnvestedEquityAwardsGrantedInPriorYearsMember ecd:PeoMember 2022-01-01 2022-12-31 0000882796 bcrx:PriorYearEndFairValueForAnyEquityAwardsForfeitedInTheYearMember ecd:NonPeoNeoMember 2020-01-01 2020-12-31 0000882796 bcrx:StockAwardsAndOptionAwardsReportedInSummaryCompensationTableMember ecd:NonPeoNeoMember 2020-01-01 2020-12-31 0000882796 bcrx:StockAwardsAndOptionAwardsReportedInSummaryCompensationTableMember ecd:NonPeoNeoMember 2021-01-01 2021-12-31 0000882796 bcrx:PriorYearEndFairValueForAnyEquityAwardsForfeitedInTheYearMember ecd:NonPeoNeoMember 2022-01-01 2022-12-31 0000882796 bcrx:PriorYearEndFairValueForAnyEquityAwardsForfeitedInTheYearMember ecd:NonPeoNeoMember 2021-01-01 2021-12-31 0000882796 bcrx:StockAwardsAndOptionAwardsReportedInSummaryCompensationTableMember ecd:NonPeoNeoMember 2022-01-01 2022-12-31 0000882796 bcrx:YearEndFairValueOfOutstandingAndUnvestedEquityAwardsGrantedInTheYearMember ecd:NonPeoNeoMember 2020-01-01 2020-12-31 0000882796 bcrx:YearEndFairValueOfOutstandingAndUnvestedEquityAwardsGrantedInTheYearMember ecd:NonPeoNeoMember 2022-01-01 2022-12-31 0000882796 bcrx:YearEndFairValueOfOutstandingAndUnvestedEquityAwardsGrantedInTheYearMember ecd:NonPeoNeoMember 2021-01-01 2021-12-31 0000882796 bcrx:YearOverYearChangeInFairValueOfOutstandingAndUnvestedEquityAwardsGrantedInPriorYearsMember ecd:NonPeoNeoMember 2020-01-01 2020-12-31 0000882796 bcrx:YearOverYearChangeInFairValueOfOutstandingAndUnvestedEquityAwardsGrantedInPriorYearsMember ecd:NonPeoNeoMember 2022-01-01 2022-12-31 0000882796 bcrx:YearOverYearChangeInFairValueOfOutstandingAndUnvestedEquityAwardsGrantedInPriorYearsMember ecd:NonPeoNeoMember 2021-01-01 2021-12-31 0000882796 bcrx:YearOverYearChangeInFairValueFromTheEndOfThePriorYearThroughTheVestingDateOfEquityAwardsGrantedInPriorYearsThatVestedInTheYearMember ecd:NonPeoNeoMember 2021-01-01 2021-12-31 0000882796 bcrx:YearOverYearChangeInFairValueFromTheEndOfThePriorYearThroughTheVestingDateOfEquityAwardsGrantedInPriorYearsThatVestedInTheYearMember ecd:NonPeoNeoMember 2022-01-01 2022-12-31 0000882796 bcrx:YearOverYearChangeInFairValueFromTheEndOfThePriorYearThroughTheVestingDateOfEquityAwardsGrantedInPriorYearsThatVestedInTheYearMember ecd:NonPeoNeoMember 2020-01-01 2020-12-31 0000882796 1 2022-01-01 2022-12-31 0000882796 2019-12-31 iso4217:USD iso4217:USD shares DEF 14A false 0000882796 BIOCRYST PHARMACEUTICALS, INC. <div class="h2" style="color: #000000; font-family: 'Times New Roman', Times, serif; font-size: 10pt; font-weight: bold; margin-top: 6.75pt; margin-left: 0pt; text-align: left;">Pay Versus Performance</div> <div style="display:none;"><br/></div> <div class="para" style="color: #000000; font-family: 'Times New Roman', Times, serif; font-size: 10pt; margin-top: 6pt; margin-left: 0pt; text-indent: 20pt; text-align: justify;">As required by Section 953(a) of the Dodd-Frank Act, and Item 402(v) of Regulation S-K, we are providing the following information about the relationship between executive “compensation actually paid” and certain financial performance of the Company. For further information concerning the Company’s pay-for-performance philosophy and how the Company aligns executive compensation with the Company’s performance, refer to the “Compensation Discussion and Analysis” section above.</div> <table cellpadding="0" cellspacing="0" class="fintab" style="margin-top: 4pt; border-collapse: collapse; width: 468pt; margin-left: auto; margin-right: auto;"> <tr class="header"> <td style="width: 7.69%; text-align: left; vertical-align: bottom; padding-top: 6pt; padding-bottom: 3.25pt;"> <div class="fpara" style="color: #000000; font-family: 'Times New Roman', Times, serif; font-size: 8pt; font-weight: bold;"> </div> </td> <td class="gutter" style="width: 0.74%; border-bottom: none; font-size: 2pt; padding-top: 6pt; padding-bottom: 3.25pt;">​</td> <td class="gutter" style="width: 0.74%; border-bottom: none; font-size: 2pt; padding-top: 6pt; padding-bottom: 3.25pt;">​</td> <td style="width: 10.54%; text-align: center; vertical-align: bottom; padding-top: 6pt; padding-bottom: 3.25pt;"> <div class="fpara" style="color: #000000; font-family: 'Times New Roman', Times, serif; font-size: 8pt; font-weight: bold;"> </div> </td> <td class="gutter" style="width: 0.74%; border-bottom: none; font-size: 2pt; padding-top: 6pt; padding-bottom: 3.25pt;">​</td> <td class="gutter" style="width: 0.74%; border-bottom: none; font-size: 2pt; padding-top: 6pt; padding-bottom: 3.25pt;">​</td> <td style="width: 10.54%; text-align: center; vertical-align: bottom; padding-top: 6pt; padding-bottom: 3.25pt;"> <div class="fpara" style="color: #000000; font-family: 'Times New Roman', Times, serif; font-size: 8pt; font-weight: bold;"> </div> </td> <td class="gutter" style="width: 0.74%; border-bottom: none; font-size: 2pt; padding-top: 6pt; padding-bottom: 3.25pt;">​</td> <td class="gutter" style="width: 0.74%; border-bottom: none; font-size: 2pt; padding-top: 6pt; padding-bottom: 3.25pt;">​</td> <td style="width: 10.54%; text-align: center; vertical-align: bottom; padding-top: 6pt; padding-bottom: 3.25pt;"> <div class="fpara" style="color: #000000; font-family: 'Times New Roman', Times, serif; font-size: 8pt; font-weight: bold;"> </div> </td> <td class="gutter" style="width: 0.74%; border-bottom: none; font-size: 2pt; padding-top: 6pt; padding-bottom: 3.25pt;">​</td> <td class="gutter" style="width: 0.74%; border-bottom: none; font-size: 2pt; padding-top: 6pt; padding-bottom: 3.25pt;">​</td> <td style="width: 10.54%; text-align: center; vertical-align: bottom; padding-top: 6pt; padding-bottom: 3.25pt;"> <div class="fpara" style="color: #000000; font-family: 'Times New Roman', Times, serif; font-size: 8pt; font-weight: bold;"> </div> </td> <td class="gutter" style="width: 0.74%; border-bottom: none; font-size: 2pt; padding-top: 6pt; padding-bottom: 3.25pt;">​</td> <td class="gutter" style="width: 0.74%; font-size: 2pt; padding-top: 6pt; padding-bottom: 3.25pt; border-bottom: 1px solid #ffffff;">​</td> <td colspan="4" style="width: 20.41%; text-align: center; vertical-align: bottom; border-bottom: 1pt solid #000000; padding-top: 6pt; padding-bottom: 3.25pt;"> <div class="fpara" style="color: #000000; font-family: 'Times New Roman', Times, serif; font-size: 8pt; font-weight: bold; margin-top: 0pt; text-align: center;">Value of Initial Fixed $100 <br/> </div> <div class="fpara" style="color: #000000; font-family: 'Times New Roman', Times, serif; font-size: 8pt; font-weight: bold; margin-top: 0pt; text-align: center;">Investment Based On:</div> </td> <td class="gutter" style="width: 0.74%; font-size: 2pt; padding-top: 6pt; padding-bottom: 3.25pt; border-bottom: 1px solid #ffffff;">​</td> <td class="gutter" style="width: 0.74%; border-bottom: none; font-size: 2pt; padding-top: 6pt; padding-bottom: 3.25pt;">​</td> <td style="width: 9.47%; text-align: center; vertical-align: bottom; padding-top: 6pt; padding-bottom: 3.25pt;"> <div class="fpara" style="color: #000000; font-family: 'Times New Roman', Times, serif; font-size: 8pt; font-weight: bold;"> </div> </td> <td class="gutter" style="width: 0.74%; border-bottom: none; font-size: 2pt; padding-top: 6pt; padding-bottom: 3.25pt;">​</td> <td class="gutter" style="width: 0.74%; border-bottom: none; font-size: 2pt; padding-top: 6pt; padding-bottom: 3.25pt;">​</td> <td style="width: 9.87%; text-align: center; vertical-align: bottom; padding-top: 6pt; padding-bottom: 3.25pt;"> <div class="fpara" style="color: #000000; font-family: 'Times New Roman', Times, serif; font-size: 8pt; font-weight: bold;"> </div> </td> </tr> <tr class="header"> <td style="width: 7.69%; text-align: center; vertical-align: bottom; border-bottom: 1pt solid #000000; padding-top: 3.25pt; padding-bottom: 3.25pt;"> <div class="fpara" style="color: #000000; font-family: 'Times New Roman', Times, serif; font-size: 8pt; font-weight: bold; margin-top: 0pt; text-align: center;">Year</div> </td> <td class="gutter" style="width: 0.74%; font-size: 2pt; padding-top: 3.25pt; padding-bottom: 3.25pt; border-bottom: 1px solid #ffffff;">​</td> <td class="gutter" style="width: 0.74%; font-size: 2pt; padding-top: 3.25pt; padding-bottom: 3.25pt; border-bottom: 1px solid #ffffff;">​</td> <td style="width: 10.54%; text-align: center; vertical-align: bottom; border-bottom: 1pt solid #000000; padding-top: 3.25pt; padding-bottom: 3.25pt;"> <div class="fpara" style="color: #000000; font-family: 'Times New Roman', Times, serif; font-size: 8pt; font-weight: bold; margin-top: 0pt; text-align: center;">Summary <br/> </div> <div class="fpara" style="color: #000000; font-family: 'Times New Roman', Times, serif; font-size: 8pt; font-weight: bold; margin-top: 0pt; text-align: center;">Compensation <br/> </div> <div class="fpara" style="color: #000000; font-family: 'Times New Roman', Times, serif; font-size: 8pt; font-weight: bold; margin-top: 0pt; text-align: center;">Table <br/> </div> <div class="fpara" style="color: #000000; font-family: 'Times New Roman', Times, serif; font-size: 8pt; font-weight: bold; margin-top: 0pt; text-align: center;">Total for <br/> </div> <div class="fpara" style="color: #000000; font-family: 'Times New Roman', Times, serif; font-size: 8pt; font-weight: bold; margin-top: 0pt; text-align: center;">PEO<br/> </div> <div class="fpara" style="color: #000000; font-family: 'Times New Roman', Times, serif; font-size: 8pt; font-weight: bold; margin-top: 0pt; text-align: center;">($)⁽¹⁾</div> </td> <td class="gutter" style="width: 0.74%; font-size: 2pt; padding-top: 3.25pt; padding-bottom: 3.25pt; border-bottom: 1px solid #ffffff;">​</td> <td class="gutter" style="width: 0.74%; font-size: 2pt; padding-top: 3.25pt; padding-bottom: 3.25pt; border-bottom: 1px solid #ffffff;">​</td> <td style="width: 10.54%; text-align: center; vertical-align: bottom; border-bottom: 1pt solid #000000; padding-top: 3.25pt; padding-bottom: 3.25pt;"> <div class="fpara" style="color: #000000; font-family: 'Times New Roman', Times, serif; font-size: 8pt; font-weight: bold; margin-top: 0pt; text-align: center;">Compensation <br/> </div> <div class="fpara" style="color: #000000; font-family: 'Times New Roman', Times, serif; font-size: 8pt; font-weight: bold; margin-top: 0pt; text-align: center;">Actually <br/> </div> <div class="fpara" style="color: #000000; font-family: 'Times New Roman', Times, serif; font-size: 8pt; font-weight: bold; margin-top: 0pt; text-align: center;">Paid to PEO<br/> </div> <div class="fpara" style="color: #000000; font-family: 'Times New Roman', Times, serif; font-size: 8pt; font-weight: bold; margin-top: 0pt; text-align: center;">($)⁽²⁾</div> </td> <td class="gutter" style="width: 0.74%; font-size: 2pt; padding-top: 3.25pt; padding-bottom: 3.25pt; border-bottom: 1px solid #ffffff;">​</td> <td class="gutter" style="width: 0.74%; font-size: 2pt; padding-top: 3.25pt; padding-bottom: 3.25pt; border-bottom: 1px solid #ffffff;">​</td> <td style="width: 10.54%; text-align: center; vertical-align: bottom; border-bottom: 1pt solid #000000; padding-top: 3.25pt; padding-bottom: 3.25pt;"> <div class="fpara" style="color: #000000; font-family: 'Times New Roman', Times, serif; font-size: 8pt; font-weight: bold; margin-top: 0pt; text-align: center;">Average <br/> </div> <div class="fpara" style="color: #000000; font-family: 'Times New Roman', Times, serif; font-size: 8pt; font-weight: bold; margin-top: 0pt; text-align: center;">Summary <br/> </div> <div class="fpara" style="color: #000000; font-family: 'Times New Roman', Times, serif; font-size: 8pt; font-weight: bold; margin-top: 0pt; text-align: center;">Compensation <br/> </div> <div class="fpara" style="color: #000000; font-family: 'Times New Roman', Times, serif; font-size: 8pt; font-weight: bold; margin-top: 0pt; text-align: center;">Table <br/> </div> <div class="fpara" style="color: #000000; font-family: 'Times New Roman', Times, serif; font-size: 8pt; font-weight: bold; margin-top: 0pt; text-align: center;">Total for <br/> </div> <div class="fpara" style="color: #000000; font-family: 'Times New Roman', Times, serif; font-size: 8pt; font-weight: bold; margin-top: 0pt; text-align: center;">Non-PEO <br/> </div> <div class="fpara" style="color: #000000; font-family: 'Times New Roman', Times, serif; font-size: 8pt; font-weight: bold; margin-top: 0pt; text-align: center;">NEOs<br/> </div> <div class="fpara" style="color: #000000; font-family: 'Times New Roman', Times, serif; font-size: 8pt; font-weight: bold; margin-top: 0pt; text-align: center;">($)⁽³⁾</div> </td> <td class="gutter" style="width: 0.74%; font-size: 2pt; padding-top: 3.25pt; padding-bottom: 3.25pt; border-bottom: 1px solid #ffffff;">​</td> <td class="gutter" style="width: 0.74%; font-size: 2pt; padding-top: 3.25pt; padding-bottom: 3.25pt; border-bottom: 1px solid #ffffff;">​</td> <td style="width: 10.54%; text-align: center; vertical-align: bottom; border-bottom: 1pt solid #000000; padding-top: 3.25pt; padding-bottom: 3.25pt;"> <div class="fpara" style="color: #000000; font-family: 'Times New Roman', Times, serif; font-size: 8pt; font-weight: bold; margin-top: 0pt; text-align: center;">Average <br/> </div> <div class="fpara" style="color: #000000; font-family: 'Times New Roman', Times, serif; font-size: 8pt; font-weight: bold; margin-top: 0pt; text-align: center;">Compensation <br/> </div> <div class="fpara" style="color: #000000; font-family: 'Times New Roman', Times, serif; font-size: 8pt; font-weight: bold; margin-top: 0pt; text-align: center;">Actually <br/> </div> <div class="fpara" style="color: #000000; font-family: 'Times New Roman', Times, serif; font-size: 8pt; font-weight: bold; margin-top: 0pt; text-align: center;">Paid to Non-<br/> </div> <div class="fpara" style="color: #000000; font-family: 'Times New Roman', Times, serif; font-size: 8pt; font-weight: bold; margin-top: 0pt; text-align: center;">PEO NEOs<br/> </div> <div class="fpara" style="color: #000000; font-family: 'Times New Roman', Times, serif; font-size: 8pt; font-weight: bold; margin-top: 0pt; text-align: center;">($)⁽⁴⁾</div> </td> <td class="gutter" style="width: 0.74%; font-size: 2pt; padding-top: 3.25pt; padding-bottom: 3.25pt; border-bottom: 1px solid #ffffff;">​</td> <td class="gutter" style="width: 0.74%; font-size: 2pt; padding-top: 3.25pt; padding-bottom: 3.25pt; border-bottom: 1px solid #ffffff;">​</td> <td style="width: 9.46%; text-align: center; vertical-align: bottom; border-bottom: 1pt solid #000000; padding-top: 3.25pt; padding-bottom: 3.25pt;"> <div class="fpara" style="color: #000000; font-family: 'Times New Roman', Times, serif; font-size: 8pt; font-weight: bold; margin-top: 0pt; text-align: center;">Total <br/> </div> <div class="fpara" style="color: #000000; font-family: 'Times New Roman', Times, serif; font-size: 8pt; font-weight: bold; margin-top: 0pt; text-align: center;">Stockholder <br/> </div> <div class="fpara" style="color: #000000; font-family: 'Times New Roman', Times, serif; font-size: 8pt; font-weight: bold; margin-top: 0pt; text-align: center;">Return<br/> </div> <div class="fpara" style="color: #000000; font-family: 'Times New Roman', Times, serif; font-size: 8pt; font-weight: bold; margin-top: 0pt; text-align: center;">($)⁽⁵⁾</div> </td> <td class="gutter" style="width: 0.74%; font-size: 2pt; padding-top: 3.25pt; padding-bottom: 3.25pt; border-bottom: 1px solid #ffffff;">​</td> <td class="gutter" style="width: 0.74%; font-size: 2pt; padding-top: 3.25pt; padding-bottom: 3.25pt; border-bottom: 1px solid #ffffff;">​</td> <td style="width: 9.46%; text-align: center; vertical-align: bottom; border-bottom: 1pt solid #000000; padding-top: 3.25pt; padding-bottom: 3.25pt;"> <div class="fpara" style="color: #000000; font-family: 'Times New Roman', Times, serif; font-size: 8pt; font-weight: bold; margin-top: 0pt; text-align: center;">Peer <br/> </div> <div class="fpara" style="color: #000000; font-family: 'Times New Roman', Times, serif; font-size: 8pt; font-weight: bold; margin-top: 0pt; text-align: center;">Group <br/> </div> <div class="fpara" style="color: #000000; font-family: 'Times New Roman', Times, serif; font-size: 8pt; font-weight: bold; margin-top: 0pt; text-align: center;">Total <br/> </div> <div class="fpara" style="color: #000000; font-family: 'Times New Roman', Times, serif; font-size: 8pt; font-weight: bold; margin-top: 0pt; text-align: center;">Stockholder <br/> </div> <div class="fpara" style="color: #000000; font-family: 'Times New Roman', Times, serif; font-size: 8pt; font-weight: bold; margin-top: 0pt; text-align: center;">Return<br/> </div> <div class="fpara" style="color: #000000; font-family: 'Times New Roman', Times, serif; font-size: 8pt; font-weight: bold; margin-top: 0pt; text-align: center;">($)⁽⁶⁾</div> </td> <td class="gutter" style="width: 0.74%; font-size: 2pt; padding-top: 3.25pt; padding-bottom: 3.25pt; border-bottom: 1px solid #ffffff;">​</td> <td class="gutter" style="width: 0.74%; font-size: 2pt; padding-top: 3.25pt; padding-bottom: 3.25pt; border-bottom: 1px solid #ffffff;">​</td> <td style="width: 9.47%; text-align: center; vertical-align: bottom; border-bottom: 1pt solid #000000; padding-top: 3.25pt; padding-bottom: 3.25pt;"> <div class="fpara" style="color: #000000; font-family: 'Times New Roman', Times, serif; font-size: 8pt; font-weight: bold; margin-top: 0pt; text-align: center;">Net <br/> </div> <div class="fpara" style="color: #000000; font-family: 'Times New Roman', Times, serif; font-size: 8pt; font-weight: bold; margin-top: 0pt; text-align: center;">Income <br/> </div> <div class="fpara" style="color: #000000; font-family: 'Times New Roman', Times, serif; font-size: 8pt; font-weight: bold; margin-top: 0pt; text-align: center;">(Loss)<br/> </div> <div class="fpara" style="color: #000000; font-family: 'Times New Roman', Times, serif; font-size: 8pt; font-weight: bold; margin-top: 0pt; text-align: center;">($ in <br/> </div> <div class="fpara" style="color: #000000; font-family: 'Times New Roman', Times, serif; font-size: 8pt; font-weight: bold; margin-top: 0pt; text-align: center;">thousands)⁽⁷⁾</div> </td> <td class="gutter" style="width: 0.74%; font-size: 2pt; padding-top: 3.25pt; padding-bottom: 3.25pt; border-bottom: 1px solid #ffffff;">​</td> <td class="gutter" style="width: 0.74%; font-size: 2pt; padding-top: 3.25pt; padding-bottom: 3.25pt; border-bottom: 1px solid #ffffff;">​</td> <td style="width: 9.87%; text-align: center; vertical-align: bottom; border-bottom: 1pt solid #000000; padding-top: 3.25pt; padding-bottom: 3.25pt;"><span style="font-weight: bold; font-family: 'Times New Roman'; font-size: 8pt;">ORLADEYO Sales</span><br/> <div class="fpara" style="color: #000000; font-family: 'Times New Roman', Times, serif; font-size: 8pt; font-weight: bold; margin-top: 0pt; text-align: center;">($ in <br/> </div> <div class="fpara" style="color: #000000; font-family: 'Times New Roman', Times, serif; font-size: 8pt; font-weight: bold; margin-top: 0pt; text-align: center;">thousands)⁽⁸⁾</div> </td> </tr> <tr> <td style="width: 7.69%; text-align: center; vertical-align: bottom; padding-top: 3.25pt; padding-bottom: 2pt; background-color: #CCEEFF;"> <div class="fpara" style="color: #000000; font-family: 'Times New Roman', Times, serif; font-size: 10pt; margin-top: 0pt; text-align: center;">2022</div> </td> <td class="gutter" style="width: 0.74%; border-bottom: none; font-size: 2pt; padding-top: 3.25pt; padding-bottom: 2pt; background-color: #CCEEFF;">​</td> <td class="gutter" style="width: 0.74%; border-bottom: none; font-size: 2pt; padding-top: 3.25pt; padding-bottom: 2pt; background-color: #CCEEFF;">​</td> <td style="width: 10.54%; text-align: center; vertical-align: bottom; white-space: nowrap; padding-top: 3.25pt; padding-bottom: 2pt; background-color: #CCEEFF;"> <div class="fpara" style="color: #000000; font-family: 'Times New Roman', Times, serif; font-size: 10pt; margin-top: 0pt; margin-left: 4.66pt; text-align: left;">6,982,994</div> </td> <td class="gutter" style="width: 0.74%; border-bottom: none; font-size: 2pt; padding-top: 3.25pt; padding-bottom: 2pt; background-color: #CCEEFF;">​</td> <td class="gutter" style="width: 0.74%; border-bottom: none; font-size: 2pt; padding-top: 3.25pt; padding-bottom: 2pt; background-color: #CCEEFF;">​</td> <td style="width: 10.54%; text-align: left; vertical-align: bottom; white-space: nowrap; padding-top: 3.25pt; padding-bottom: 2pt; background-color: #CCEEFF;"> <div class="fpara" style="color: #000000; font-family: 'Times New Roman', Times, serif; font-size: 10pt; margin-top: 0pt; margin-left: 2.16pt; text-align: left;"><span style="padding-left: 5pt;">4,009,070</span></div> </td> <td class="gutter" style="width: 0.74%; border-bottom: none; font-size: 2pt; padding-top: 3.25pt; padding-bottom: 2pt; background-color: #CCEEFF;">​</td> <td class="gutter" style="width: 0.74%; border-bottom: none; font-size: 2pt; padding-top: 3.25pt; padding-bottom: 2pt; background-color: #CCEEFF;">​</td> <td style="width: 10.54%; text-align: center; vertical-align: bottom; white-space: nowrap; padding-top: 3.25pt; padding-bottom: 2pt; background-color: #CCEEFF;"> <div class="fpara" style="color: #000000; font-family: 'Times New Roman', Times, serif; font-size: 10pt; margin-top: 0pt; margin-left: 4.67pt; text-align: left;">2,568,935</div> </td> <td class="gutter" style="width: 0.74%; border-bottom: none; font-size: 2pt; padding-top: 3.25pt; padding-bottom: 2pt; background-color: #CCEEFF;">​</td> <td class="gutter" style="width: 0.74%; border-bottom: none; font-size: 2pt; padding-top: 3.25pt; padding-bottom: 2pt; background-color: #CCEEFF;">​</td> <td style="width: 10.54%; text-align: center; vertical-align: bottom; white-space: nowrap; padding-top: 3.25pt; padding-bottom: 2pt; background-color: #CCEEFF;"> <div class="fpara" style="color: #000000; font-family: 'Times New Roman', Times, serif; font-size: 10pt; margin-top: 0pt; margin-left: 4.66pt; text-align: left;">1,452,633</div> </td> <td class="gutter" style="width: 0.74%; border-bottom: none; font-size: 2pt; padding-top: 3.25pt; padding-bottom: 2pt; background-color: #CCEEFF;">​</td> <td class="gutter" style="width: 0.74%; border-bottom: none; font-size: 2pt; padding-top: 3.25pt; padding-bottom: 2pt; background-color: #CCEEFF;">​</td> <td style="width: 9.46%; text-align: center; vertical-align: bottom; white-space: nowrap; padding-top: 3.25pt; padding-bottom: 2pt; background-color: #CCEEFF;"> <div class="fpara" style="color: #000000; font-family: 'Times New Roman', Times, serif; font-size: 10pt; margin-top: 0pt; margin-left: 8.39pt; text-align: left;">332.75</div> </td> <td class="gutter" style="width: 0.74%; border-bottom: none; font-size: 2pt; padding-top: 3.25pt; padding-bottom: 2pt; background-color: #CCEEFF;">​</td> <td class="gutter" style="width: 0.74%; border-bottom: none; font-size: 2pt; padding-top: 3.25pt; padding-bottom: 2pt; background-color: #CCEEFF;">​</td> <td style="width: 9.46%; text-align: center; vertical-align: bottom; white-space: nowrap; padding-top: 3.25pt; padding-bottom: 2pt; background-color: #CCEEFF;"> <div class="fpara" style="color: #000000; font-family: 'Times New Roman', Times, serif; font-size: 10pt; margin-top: 0pt; margin-left: 8.4pt; text-align: left;">153.08</div> </td> <td class="gutter" style="width: 0.74%; border-bottom: none; font-size: 2pt; padding-top: 3.25pt; padding-bottom: 2pt; background-color: #CCEEFF;">​</td> <td class="gutter" style="width: 0.74%; border-bottom: none; font-size: 2pt; padding-top: 3.25pt; padding-bottom: 2pt; background-color: #CCEEFF;">​</td> <td style="width: 9.47%; text-align: left; vertical-align: bottom; white-space: nowrap; padding-top: 3.25pt; padding-bottom: 2pt; background-color: #CCEEFF;"> <div class="fpara" style="color: #000000; font-family: 'Times New Roman', Times, serif; font-size: 10pt; margin-top: 0pt; margin-left: 4.25pt; text-align: left;"><span style="padding-left: 0.37pt;">(247,116)</span></div> </td> <td class="gutter" style="width: 0.74%; border-bottom: none; font-size: 2pt; padding-top: 3.25pt; padding-bottom: 2pt; background-color: #CCEEFF;">​</td> <td class="gutter" style="width: 0.74%; border-bottom: none; font-size: 2pt; padding-top: 3.25pt; padding-bottom: 2pt; background-color: #CCEEFF;">​</td> <td style="width: 9.87%; text-align: left; vertical-align: bottom; white-space: nowrap; padding-top: 3.25pt; padding-bottom: 2pt; background-color: #CCEEFF;"> <div class="fpara" style="color: #000000; font-family: 'Times New Roman', Times, serif; font-size: 10pt; margin-top: 0pt; margin-left: 6.85pt; text-align: left;">249,689</div> </td> </tr> <tr> <td style="width: 7.69%; text-align: center; vertical-align: bottom; padding-top: 2pt; padding-bottom: 2pt;"> <div class="fpara" style="color: #000000; font-family: 'Times New Roman', Times, serif; font-size: 10pt; margin-top: 0pt; text-align: center;">2021</div> </td> <td class="gutter" style="width: 0.74%; border-bottom: none; font-size: 2pt; padding-top: 2pt; padding-bottom: 2pt;">​</td> <td class="gutter" style="width: 0.74%; border-bottom: none; font-size: 2pt; padding-top: 2pt; padding-bottom: 2pt;">​</td> <td style="width: 10.54%; text-align: center; vertical-align: bottom; white-space: nowrap; padding-top: 2pt; padding-bottom: 2pt;"> <div class="fpara" style="color: #000000; font-family: 'Times New Roman', Times, serif; font-size: 10pt; margin-top: 0pt; margin-left: 4.66pt; text-align: left;">7,061,225</div> </td> <td class="gutter" style="width: 0.74%; border-bottom: none; font-size: 2pt; padding-top: 2pt; padding-bottom: 2pt;">​</td> <td class="gutter" style="width: 0.74%; border-bottom: none; font-size: 2pt; padding-top: 2pt; padding-bottom: 2pt;">​</td> <td style="width: 10.54%; text-align: left; vertical-align: bottom; white-space: nowrap; padding-top: 2pt; padding-bottom: 2pt;"> <div class="fpara" style="color: #000000; font-family: 'Times New Roman', Times, serif; font-size: 10pt; margin-top: 0pt; margin-left: 2.16pt; text-align: left;">17,053,230</div> </td> <td class="gutter" style="width: 0.74%; border-bottom: none; font-size: 2pt; padding-top: 2pt; padding-bottom: 2pt;">​</td> <td class="gutter" style="width: 0.74%; border-bottom: none; font-size: 2pt; padding-top: 2pt; padding-bottom: 2pt;">​</td> <td style="width: 10.54%; text-align: center; vertical-align: bottom; white-space: nowrap; padding-top: 2pt; padding-bottom: 2pt;"> <div class="fpara" style="color: #000000; font-family: 'Times New Roman', Times, serif; font-size: 10pt; margin-top: 0pt; margin-left: 4.67pt; text-align: left;">4,523,739</div> </td> <td class="gutter" style="width: 0.74%; border-bottom: none; font-size: 2pt; padding-top: 2pt; padding-bottom: 2pt;">​</td> <td class="gutter" style="width: 0.74%; border-bottom: none; font-size: 2pt; padding-top: 2pt; padding-bottom: 2pt;">​</td> <td style="width: 10.54%; text-align: center; vertical-align: bottom; white-space: nowrap; padding-top: 2pt; padding-bottom: 2pt;"> <div class="fpara" style="color: #000000; font-family: 'Times New Roman', Times, serif; font-size: 10pt; margin-top: 0pt; margin-left: 4.66pt; text-align: left;">7,254,142</div> </td> <td class="gutter" style="width: 0.74%; border-bottom: none; font-size: 2pt; padding-top: 2pt; padding-bottom: 2pt;">​</td> <td class="gutter" style="width: 0.74%; border-bottom: none; font-size: 2pt; padding-top: 2pt; padding-bottom: 2pt;">​</td> <td style="width: 9.46%; text-align: center; vertical-align: bottom; white-space: nowrap; padding-top: 2pt; padding-bottom: 2pt;"> <div class="fpara" style="color: #000000; font-family: 'Times New Roman', Times, serif; font-size: 10pt; margin-top: 0pt; margin-left: 8.39pt; text-align: left;">401.45</div> </td> <td class="gutter" style="width: 0.74%; border-bottom: none; font-size: 2pt; padding-top: 2pt; padding-bottom: 2pt;">​</td> <td class="gutter" style="width: 0.74%; border-bottom: none; font-size: 2pt; padding-top: 2pt; padding-bottom: 2pt;">​</td> <td style="width: 9.46%; text-align: center; vertical-align: bottom; white-space: nowrap; padding-top: 2pt; padding-bottom: 2pt;"> <div class="fpara" style="color: #000000; font-family: 'Times New Roman', Times, serif; font-size: 10pt; margin-top: 0pt; margin-left: 8.4pt; text-align: left;">137.47</div> </td> <td class="gutter" style="width: 0.74%; border-bottom: none; font-size: 2pt; padding-top: 2pt; padding-bottom: 2pt;">​</td> <td class="gutter" style="width: 0.74%; border-bottom: none; font-size: 2pt; padding-top: 2pt; padding-bottom: 2pt;">​</td> <td style="width: 9.47%; text-align: left; vertical-align: bottom; white-space: nowrap; padding-top: 2pt; padding-bottom: 2pt;"> <div class="fpara" style="color: #000000; font-family: 'Times New Roman', Times, serif; font-size: 10pt; margin-top: 0pt; margin-left: 4.25pt; text-align: left;">(184,062)</div> </td> <td class="gutter" style="width: 0.74%; border-bottom: none; font-size: 2pt; padding-top: 2pt; padding-bottom: 2pt;">​</td> <td class="gutter" style="width: 0.74%; border-bottom: none; font-size: 2pt; padding-top: 2pt; padding-bottom: 2pt;">​</td> <td style="width: 9.87%; text-align: left; vertical-align: bottom; white-space: nowrap; padding-top: 2pt; padding-bottom: 2pt;"> <div class="fpara" style="color: #000000; font-family: 'Times New Roman', Times, serif; font-size: 10pt; margin-top: 0pt; margin-left: 6.85pt; text-align: left;">121,865</div> </td> </tr> <tr> <td style="width: 7.69%; text-align: center; vertical-align: bottom; padding-top: 2pt; padding-bottom: 3pt; background-color: #CCEEFF;"> <div class="fpara" style="color: #000000; font-family: 'Times New Roman', Times, serif; font-size: 10pt; margin-top: 0pt; text-align: center;">2020</div> </td> <td class="gutter" style="width: 0.74%; border-bottom: none; font-size: 2pt; padding-top: 2pt; padding-bottom: 3pt; background-color: #CCEEFF;">​</td> <td class="gutter" style="width: 0.74%; border-bottom: none; font-size: 2pt; padding-top: 2pt; padding-bottom: 3pt; background-color: #CCEEFF;">​</td> <td style="width: 10.54%; text-align: center; vertical-align: bottom; white-space: nowrap; padding-top: 2pt; padding-bottom: 3pt; background-color: #CCEEFF;"> <div class="fpara" style="color: #000000; font-family: 'Times New Roman', Times, serif; font-size: 10pt; margin-top: 0pt; margin-left: 4.66pt; text-align: left;">6,034,941</div> </td> <td class="gutter" style="width: 0.74%; border-bottom: none; font-size: 2pt; padding-top: 2pt; padding-bottom: 3pt; background-color: #CCEEFF;">​</td> <td class="gutter" style="width: 0.74%; border-bottom: none; font-size: 2pt; padding-top: 2pt; padding-bottom: 3pt; background-color: #CCEEFF;">​</td> <td style="width: 10.54%; text-align: left; vertical-align: bottom; white-space: nowrap; padding-top: 2pt; padding-bottom: 3pt; background-color: #CCEEFF;"> <div class="fpara" style="color: #000000; font-family: 'Times New Roman', Times, serif; font-size: 10pt; margin-top: 0pt; margin-left: 2.16pt; text-align: left;">10,853,629</div> </td> <td class="gutter" style="width: 0.74%; border-bottom: none; font-size: 2pt; padding-top: 2pt; padding-bottom: 3pt; background-color: #CCEEFF;">​</td> <td class="gutter" style="width: 0.74%; border-bottom: none; font-size: 2pt; padding-top: 2pt; padding-bottom: 3pt; background-color: #CCEEFF;">​</td> <td style="width: 10.54%; text-align: center; vertical-align: bottom; white-space: nowrap; padding-top: 2pt; padding-bottom: 3pt; background-color: #CCEEFF;"> <div class="fpara" style="color: #000000; font-family: 'Times New Roman', Times, serif; font-size: 10pt; margin-top: 0pt; margin-left: 4.67pt; text-align: left;">2,353,552</div> </td> <td class="gutter" style="width: 0.74%; border-bottom: none; font-size: 2pt; padding-top: 2pt; padding-bottom: 3pt; background-color: #CCEEFF;">​</td> <td class="gutter" style="width: 0.74%; border-bottom: none; font-size: 2pt; padding-top: 2pt; padding-bottom: 3pt; background-color: #CCEEFF;">​</td> <td style="width: 10.54%; text-align: center; vertical-align: bottom; white-space: nowrap; padding-top: 2pt; padding-bottom: 3pt; background-color: #CCEEFF;"> <div class="fpara" style="color: #000000; font-family: 'Times New Roman', Times, serif; font-size: 10pt; margin-top: 0pt; margin-left: 4.66pt; text-align: left;">3,630,213</div> </td> <td class="gutter" style="width: 0.74%; border-bottom: none; font-size: 2pt; padding-top: 2pt; padding-bottom: 3pt; background-color: #CCEEFF;">​</td> <td class="gutter" style="width: 0.74%; border-bottom: none; font-size: 2pt; padding-top: 2pt; padding-bottom: 3pt; background-color: #CCEEFF;">​</td> <td style="width: 9.46%; text-align: center; vertical-align: bottom; white-space: nowrap; padding-top: 2pt; padding-bottom: 3pt; background-color: #CCEEFF;"> <div class="fpara" style="color: #000000; font-family: 'Times New Roman', Times, serif; font-size: 10pt; margin-top: 0pt; margin-left: 8.39pt; text-align: left;">215.94</div> </td> <td class="gutter" style="width: 0.74%; border-bottom: none; font-size: 2pt; padding-top: 2pt; padding-bottom: 3pt; background-color: #CCEEFF;">​</td> <td class="gutter" style="width: 0.74%; border-bottom: none; font-size: 2pt; padding-top: 2pt; padding-bottom: 3pt; background-color: #CCEEFF;">​</td> <td style="width: 9.46%; text-align: center; vertical-align: bottom; white-space: nowrap; padding-top: 2pt; padding-bottom: 3pt; background-color: #CCEEFF;"> <div class="fpara" style="color: #000000; font-family: 'Times New Roman', Times, serif; font-size: 10pt; margin-top: 0pt; margin-left: 8.4pt; text-align: left;"><span style="padding-left: 0.37pt;">110.52</span></div> </td> <td class="gutter" style="width: 0.74%; border-bottom: none; font-size: 2pt; padding-top: 2pt; padding-bottom: 3pt; background-color: #CCEEFF;">​</td> <td class="gutter" style="width: 0.74%; border-bottom: none; font-size: 2pt; padding-top: 2pt; padding-bottom: 3pt; background-color: #CCEEFF;">​</td> <td style="width: 9.47%; text-align: left; vertical-align: bottom; white-space: nowrap; padding-top: 2pt; padding-bottom: 3pt; background-color: #CCEEFF;"> <div class="fpara" style="color: #000000; font-family: 'Times New Roman', Times, serif; font-size: 10pt; margin-top: 0pt; margin-left: 4.25pt; text-align: left;">(182,814)</div> </td> <td class="gutter" style="width: 0.74%; border-bottom: none; font-size: 2pt; padding-top: 2pt; padding-bottom: 3pt; background-color: #CCEEFF;">​</td> <td class="gutter" style="width: 0.74%; border-bottom: none; font-size: 2pt; padding-top: 2pt; padding-bottom: 3pt; background-color: #CCEEFF;">​</td> <td style="width: 9.87%; text-align: left; vertical-align: bottom; white-space: nowrap; padding-top: 2pt; padding-bottom: 3pt; background-color: #CCEEFF;"> <div class="fpara" style="color: #000000; font-family: 'Times New Roman', Times, serif; font-size: 10pt; margin-top: 0pt; margin-left: 6.85pt; text-align: left;"><span style="padding-left: 17.5pt;">133</span></div> </td> </tr> </table> <div class="rule-partial" style="height: 0pt; width: 72pt; border-bottom: 1pt solid #000000; margin-bottom: 1pt; margin-right: auto; margin-left: 0pt; margin-top: 10.25pt;"> <br/></div> <table border="0" cellpadding="0" cellspacing="0" style="margin-top: 3pt; margin-left: 0pt;"> <tr> <td style="width: 20pt; text-align: left; vertical-align: top;"> <div style="color: #000000; font-family: 'Times New Roman', Times, serif; font-size: 8pt;">(1)<br/> </div> </td> <td style="vertical-align: top;"> <div style="color: #000000; font-family: 'Times New Roman', Times, serif; font-size: 8pt; text-align: justify;">These amounts represent the amounts reported for our CEO, Jon P. Stonehouse, in the “Total” column of the Summary Compensation Table in each applicable year.</div> </td> </tr> </table> <table border="0" cellpadding="0" cellspacing="0" style="margin-top: 3pt; margin-left: 0pt;"> <tr> <td style="width: 20pt; text-align: left; vertical-align: top;"> <div style="color: #000000; font-family: 'Times New Roman', Times, serif; font-size: 8pt;">(2)<br/> </div> </td> <td style="vertical-align: top;"> <div style="color: #000000; font-family: 'Times New Roman', Times, serif; font-size: 8pt; text-align: justify;">These amounts represent the amount of “compensation actually paid” to Mr. Stonehouse, as computed in accordance with Item 402(v) of Regulation S-K, and do not reflect the total compensation actually realized or received by Mr. Stonehouse. In accordance with these rules, these amounts reflect total compensation as set forth in the Summary Compensation Table for each year, adjusted as shown below. Equity values are calculated in accordance with FASB ASC Topic 718, and the valuation assumptions used to calculate fair values did not materially differ from those disclosed at the time of grant.</div> </td> </tr> </table> <table cellpadding="0" cellspacing="0" class="fintab" style="margin-top: 4pt; border-collapse: collapse; width: 448pt; margin-left: 20pt;"> <tr class="header"> <td style="width: 66.96%; text-align: center; vertical-align: bottom; border-bottom: 1pt solid #000000; padding-top: 6pt; padding-bottom: 3.25pt;"> <div class="fpara" style="color: #000000; font-family: 'Times New Roman', Times, serif; font-size: 8pt; font-weight: bold; margin-top: 0pt; text-align: center;">Compensation Actually Paid to PEO</div> </td> <td class="gutter" style="width: 1.54%; font-size: 2pt; padding-top: 6pt; padding-bottom: 3.25pt; border-bottom: 1px solid #ffffff;">​</td> <td class="gutter" style="width: 1.54%; font-size: 2pt; padding-top: 6pt; padding-bottom: 3.25pt; border-bottom: 1px solid #ffffff;">​</td> <td style="width: 7.74%; text-align: center; vertical-align: bottom; border-bottom: 1pt solid #000000; padding-top: 6pt; padding-bottom: 3.25pt;"> <div class="fpara" style="color: #000000; font-family: 'Times New Roman', Times, serif; font-size: 8pt; font-weight: bold; margin-top: 0pt; text-align: center;">2022</div> </td> <td class="gutter" style="width: 1.54%; font-size: 2pt; padding-top: 6pt; padding-bottom: 3.25pt; border-bottom: 1px solid #ffffff;">​</td> <td class="gutter" style="width: 1.54%; font-size: 2pt; padding-top: 6pt; padding-bottom: 3.25pt; border-bottom: 1px solid #ffffff;">​</td> <td style="width: 8.04%; text-align: center; vertical-align: bottom; border-bottom: 1pt solid #000000; padding-top: 6pt; padding-bottom: 3.25pt;"> <div class="fpara" style="color: #000000; font-family: 'Times New Roman', Times, serif; font-size: 8pt; font-weight: bold; margin-top: 0pt; text-align: center;">2021</div> </td> <td class="gutter" style="width: 1.54%; font-size: 2pt; padding-top: 6pt; padding-bottom: 3.25pt; border-bottom: 1px solid #ffffff;">​</td> <td class="gutter" style="width: 1.54%; font-size: 2pt; padding-top: 6pt; padding-bottom: 3.25pt; border-bottom: 1px solid #ffffff;">​</td> <td style="width: 8.04%; text-align: center; vertical-align: bottom; border-bottom: 1pt solid #000000; padding-top: 6pt; padding-bottom: 3.25pt;"> <div class="fpara" style="color: #000000; font-family: 'Times New Roman', Times, serif; font-size: 8pt; font-weight: bold; margin-top: 0pt; text-align: center;">2020</div> </td> </tr> <tr> <td style="width: 66.96%; text-align: left; vertical-align: bottom; padding-top: 3.25pt; padding-bottom: 2pt; background-color: #CCEEFF;"> <div class="fpara" style="color: #000000; font-family: 'Times New Roman', Times, serif; font-size: 8pt; margin-top: 0pt; margin-left: 0pt; text-align: left;">Summary Compensation Table Total</div> </td> <td class="gutter" style="width: 1.54%; border-bottom: none; font-size: 2pt; padding-top: 3.25pt; padding-bottom: 2pt; background-color: #CCEEFF;">​</td> <td class="gutter" style="width: 1.54%; border-bottom: none; font-size: 2pt; padding-top: 3.25pt; padding-bottom: 2pt; background-color: #CCEEFF;">​</td> <td style="width: 7.74%; text-align: left; vertical-align: bottom; white-space: nowrap; padding-top: 3.25pt; padding-bottom: 2pt; background-color: #CCEEFF;"> <div class="fpara" style="color: #000000; font-family: 'Times New Roman', Times, serif; font-size: 8pt; margin-top: 0pt; margin-left: 0pt; text-align: left;"><span style="padding-left: 2.66pt;">6,982,994</span></div> </td> <td class="gutter" style="width: 1.54%; border-bottom: none; font-size: 2pt; padding-top: 3.25pt; padding-bottom: 2pt; background-color: #CCEEFF;">​</td> <td class="gutter" style="width: 1.54%; border-bottom: none; font-size: 2pt; padding-top: 3.25pt; padding-bottom: 2pt; background-color: #CCEEFF;">​</td> <td style="width: 8.04%; text-align: left; vertical-align: bottom; white-space: nowrap; padding-top: 3.25pt; padding-bottom: 2pt; background-color: #CCEEFF;"> <div class="fpara" style="color: #000000; font-family: 'Times New Roman', Times, serif; font-size: 8pt; margin-top: 0pt; margin-left: 0pt; text-align: left;"><span style="padding-left: 4pt;">7,061,225</span></div> </td> <td class="gutter" style="width: 1.54%; border-bottom: none; font-size: 2pt; padding-top: 3.25pt; padding-bottom: 2pt; background-color: #CCEEFF;">​</td> <td class="gutter" style="width: 1.54%; border-bottom: none; font-size: 2pt; padding-top: 3.25pt; padding-bottom: 2pt; background-color: #CCEEFF;">​</td> <td style="width: 8.04%; text-align: left; vertical-align: bottom; white-space: nowrap; padding-top: 3.25pt; padding-bottom: 2pt; background-color: #CCEEFF;"> <div class="fpara" style="color: #000000; font-family: 'Times New Roman', Times, serif; font-size: 8pt; margin-top: 0pt; margin-left: 0pt; text-align: left;"><span style="padding-left: 4pt;">6,034,941</span></div> </td> </tr> <tr> <td style="width: 66.96%; text-align: left; vertical-align: bottom; padding-top: 2pt; padding-bottom: 2pt;"> <div class="fpara" style="color: #000000; font-family: 'Times New Roman', Times, serif; font-size: 8pt; margin-top: 0pt; margin-left: 20pt; text-indent: -10pt; text-align: left;">(Less), value of “Stock Awards” and “Option Awards” reported in Summary Compensation Table</div> </td> <td class="gutter" style="width: 1.54%; border-bottom: none; font-size: 2pt; padding-top: 2pt; padding-bottom: 2pt;">​</td> <td class="gutter" style="width: 1.54%; border-bottom: none; font-size: 2pt; padding-top: 2pt; padding-bottom: 2pt;">​</td> <td style="width: 7.74%; text-align: left; vertical-align: bottom; white-space: nowrap; padding-top: 2pt; padding-bottom: 2pt;"> <div class="fpara" style="color: #000000; font-family: 'Times New Roman', Times, serif; font-size: 8pt; margin-top: 0pt; margin-left: 0pt; text-align: left;">(5,837,579)</div> </td> <td class="gutter" style="width: 1.54%; border-bottom: none; font-size: 2pt; padding-top: 2pt; padding-bottom: 2pt;">​</td> <td class="gutter" style="width: 1.54%; border-bottom: none; font-size: 2pt; padding-top: 2pt; padding-bottom: 2pt;">​</td> <td style="width: 8.04%; text-align: left; vertical-align: bottom; white-space: nowrap; padding-top: 2pt; padding-bottom: 2pt;"> <div class="fpara" style="color: #000000; font-family: 'Times New Roman', Times, serif; font-size: 8pt; margin-top: 0pt; margin-left: 0pt; text-align: left;"><span style="padding-left: 1.34pt;">(5,916,979)</span></div> </td> <td class="gutter" style="width: 1.54%; border-bottom: none; font-size: 2pt; padding-top: 2pt; padding-bottom: 2pt;">​</td> <td class="gutter" style="width: 1.54%; border-bottom: none; font-size: 2pt; padding-top: 2pt; padding-bottom: 2pt;">​</td> <td style="width: 8.04%; text-align: left; vertical-align: bottom; white-space: nowrap; padding-top: 2pt; padding-bottom: 2pt;"> <div class="fpara" style="color: #000000; font-family: 'Times New Roman', Times, serif; font-size: 8pt; margin-top: 0pt; margin-left: 0pt; text-align: left;"><span style="padding-left: 1.34pt;">(4,916,022)</span></div> </td> </tr> <tr> <td style="width: 66.96%; text-align: left; vertical-align: bottom; padding-top: 2pt; padding-bottom: 2pt; background-color: #CCEEFF;"> <div class="fpara" style="color: #000000; font-family: 'Times New Roman', Times, serif; font-size: 8pt; margin-top: 0pt; margin-left: 10pt; text-align: left;">Plus, year-end fair value of outstanding and unvested equity awards granted in the year</div> </td> <td class="gutter" style="width: 1.54%; border-bottom: none; font-size: 2pt; padding-top: 2pt; padding-bottom: 2pt; background-color: #CCEEFF;">​</td> <td class="gutter" style="width: 1.54%; border-bottom: none; font-size: 2pt; padding-top: 2pt; padding-bottom: 2pt; background-color: #CCEEFF;">​</td> <td style="width: 7.74%; text-align: left; vertical-align: bottom; white-space: nowrap; padding-top: 2pt; padding-bottom: 2pt; background-color: #CCEEFF;"> <div class="fpara" style="color: #000000; font-family: 'Times New Roman', Times, serif; font-size: 8pt; margin-top: 0pt; margin-left: 0pt; text-align: left;"><span style="padding-left: 2.66pt;">6,400,540</span></div> </td> <td class="gutter" style="width: 1.54%; border-bottom: none; font-size: 2pt; padding-top: 2pt; padding-bottom: 2pt; background-color: #CCEEFF;">​</td> <td class="gutter" style="width: 1.54%; border-bottom: none; font-size: 2pt; padding-top: 2pt; padding-bottom: 2pt; background-color: #CCEEFF;">​</td> <td style="width: 8.04%; text-align: left; vertical-align: bottom; white-space: nowrap; padding-top: 2pt; padding-bottom: 2pt; background-color: #CCEEFF;"> <div class="fpara" style="color: #000000; font-family: 'Times New Roman', Times, serif; font-size: 8pt; margin-top: 0pt; margin-left: 0pt; text-align: left;"><span style="padding-left: 4pt;">7,409,280</span></div> </td> <td class="gutter" style="width: 1.54%; border-bottom: none; font-size: 2pt; padding-top: 2pt; padding-bottom: 2pt; background-color: #CCEEFF;">​</td> <td class="gutter" style="width: 1.54%; border-bottom: none; font-size: 2pt; padding-top: 2pt; padding-bottom: 2pt; background-color: #CCEEFF;">​</td> <td style="width: 8.04%; text-align: left; vertical-align: bottom; white-space: nowrap; padding-top: 2pt; padding-bottom: 2pt; background-color: #CCEEFF;"> <div class="fpara" style="color: #000000; font-family: 'Times New Roman', Times, serif; font-size: 8pt; margin-top: 0pt; margin-left: 0pt; text-align: left;"><span style="padding-left: 4pt;">4,291,310</span></div> </td> </tr> <tr> <td style="width: 66.96%; text-align: left; vertical-align: bottom; padding-top: 2pt; padding-bottom: 2pt;"> <div class="fpara" style="color: #000000; font-family: 'Times New Roman', Times, serif; font-size: 8pt; margin-top: 0pt; margin-left: 20pt; text-indent: -10pt; text-align: left;">Plus (less), year-over-year change in fair value of outstanding and unvested equity awards granted in prior years</div> </td> <td class="gutter" style="width: 1.54%; border-bottom: none; font-size: 2pt; padding-top: 2pt; padding-bottom: 2pt;">​</td> <td class="gutter" style="width: 1.54%; border-bottom: none; font-size: 2pt; padding-top: 2pt; padding-bottom: 2pt;">​</td> <td style="width: 7.74%; text-align: left; vertical-align: bottom; white-space: nowrap; padding-top: 2pt; padding-bottom: 2pt;"> <div class="fpara" style="color: #000000; font-family: 'Times New Roman', Times, serif; font-size: 8pt; margin-top: 0pt; margin-left: 0pt; text-align: left;">(1,953,028)</div> </td> <td class="gutter" style="width: 1.54%; border-bottom: none; font-size: 2pt; padding-top: 2pt; padding-bottom: 2pt;">​</td> <td class="gutter" style="width: 1.54%; border-bottom: none; font-size: 2pt; padding-top: 2pt; padding-bottom: 2pt;">​</td> <td style="width: 8.04%; text-align: left; vertical-align: bottom; white-space: nowrap; padding-top: 2pt; padding-bottom: 2pt;"> <div class="fpara" style="color: #000000; font-family: 'Times New Roman', Times, serif; font-size: 8pt; margin-top: 0pt; margin-left: 0pt; text-align: left;"><span style="padding-left: 4pt;">5,604,968</span></div> </td> <td class="gutter" style="width: 1.54%; border-bottom: none; font-size: 2pt; padding-top: 2pt; padding-bottom: 2pt;">​</td> <td class="gutter" style="width: 1.54%; border-bottom: none; font-size: 2pt; padding-top: 2pt; padding-bottom: 2pt;">​</td> <td style="width: 8.04%; text-align: left; vertical-align: bottom; white-space: nowrap; padding-top: 2pt; padding-bottom: 2pt;"> <div class="fpara" style="color: #000000; font-family: 'Times New Roman', Times, serif; font-size: 8pt; margin-top: 0pt; margin-left: 0pt; text-align: left;"><span style="padding-left: 4pt;">2,621,407</span></div> </td> </tr> <tr> <td style="width: 66.96%; text-align: left; vertical-align: bottom; padding-top: 2pt; padding-bottom: 2pt; background-color: #CCEEFF;"> <div class="fpara" style="color: #000000; font-family: 'Times New Roman', Times, serif; font-size: 8pt; margin-top: 0pt; margin-left: 20pt; text-indent: -10pt; text-align: left;">Plus (less), year-over-year change in fair value (from the end of the prior year through the vesting date) of equity awards granted in prior years that vested in the year</div> </td> <td class="gutter" style="width: 1.54%; border-bottom: none; font-size: 2pt; padding-top: 2pt; padding-bottom: 2pt; background-color: #CCEEFF;">​</td> <td class="gutter" style="width: 1.54%; border-bottom: none; font-size: 2pt; padding-top: 2pt; padding-bottom: 2pt; background-color: #CCEEFF;">​</td> <td style="width: 7.74%; text-align: left; vertical-align: bottom; white-space: nowrap; padding-top: 2pt; padding-bottom: 2pt; background-color: #CCEEFF;"> <div class="fpara" style="color: #000000; font-family: 'Times New Roman', Times, serif; font-size: 8pt; margin-top: 0pt; margin-left: 0pt; text-align: left;">(1,583,857)</div> </td> <td class="gutter" style="width: 1.54%; border-bottom: none; font-size: 2pt; padding-top: 2pt; padding-bottom: 2pt; background-color: #CCEEFF;">​</td> <td class="gutter" style="width: 1.54%; border-bottom: none; font-size: 2pt; padding-top: 2pt; padding-bottom: 2pt; background-color: #CCEEFF;">​</td> <td style="width: 8.04%; text-align: left; vertical-align: bottom; white-space: nowrap; padding-top: 2pt; padding-bottom: 2pt; background-color: #CCEEFF;"> <div class="fpara" style="color: #000000; font-family: 'Times New Roman', Times, serif; font-size: 8pt; margin-top: 0pt; margin-left: 0pt; text-align: left;"><span style="padding-left: 4pt;">2,894,736</span></div> </td> <td class="gutter" style="width: 1.54%; border-bottom: none; font-size: 2pt; padding-top: 2pt; padding-bottom: 2pt; background-color: #CCEEFF;">​</td> <td class="gutter" style="width: 1.54%; border-bottom: none; font-size: 2pt; padding-top: 2pt; padding-bottom: 2pt; background-color: #CCEEFF;">​</td> <td style="width: 8.04%; text-align: left; vertical-align: bottom; white-space: nowrap; padding-top: 2pt; padding-bottom: 2pt; background-color: #CCEEFF;"> <div class="fpara" style="color: #000000; font-family: 'Times New Roman', Times, serif; font-size: 8pt; margin-top: 0pt; margin-left: 0pt; text-align: left;"><span style="padding-left: 4pt;">2,821,993</span></div> </td> </tr> <tr> <td style="width: 66.96%; text-align: left; vertical-align: bottom; padding-top: 2pt; padding-bottom: 3pt;"> <div class="fpara" style="color: #000000; font-family: 'Times New Roman', Times, serif; font-size: 8pt; font-weight: bold; margin-top: 0pt; margin-left: 0pt; text-align: left;">Compensation Actually Paid to Jon P. Stonehouse</div> </td> <td class="gutter" style="width: 1.54%; border-bottom: none; font-size: 2pt; padding-top: 2pt; padding-bottom: 3pt;">​</td> <td class="gutter" style="width: 1.54%; border-bottom: none; font-size: 2pt; padding-top: 2pt; padding-bottom: 3pt;">​</td> <td style="width: 7.74%; text-align: left; vertical-align: bottom; white-space: nowrap; padding-top: 2pt; padding-bottom: 3pt;"> <div class="fpara" style="color: #000000; font-family: 'Times New Roman', Times, serif; font-size: 8pt; font-weight: bold; margin-top: 0pt; margin-left: 0pt; text-align: left;"><span style="padding-left: 2.66pt;">4,009,070</span></div> </td> <td class="gutter" style="width: 1.54%; border-bottom: none; font-size: 2pt; padding-top: 2pt; padding-bottom: 3pt;">​</td> <td class="gutter" style="width: 1.54%; border-bottom: none; font-size: 2pt; padding-top: 2pt; padding-bottom: 3pt;">​</td> <td style="width: 8.04%; text-align: left; vertical-align: bottom; white-space: nowrap; padding-top: 2pt; padding-bottom: 3pt;"> <div class="fpara" style="color: #000000; font-family: 'Times New Roman', Times, serif; font-size: 8pt; font-weight: bold; margin-top: 0pt; margin-left: 0pt; text-align: left;">17,053,230</div> </td> <td class="gutter" style="width: 1.54%; border-bottom: none; font-size: 2pt; padding-top: 2pt; padding-bottom: 3pt;">​</td> <td class="gutter" style="width: 1.54%; border-bottom: none; font-size: 2pt; padding-top: 2pt; padding-bottom: 3pt;">​</td> <td style="width: 8.04%; text-align: left; vertical-align: bottom; white-space: nowrap; padding-top: 2pt; padding-bottom: 3pt;"> <div class="fpara" style="color: #000000; font-family: 'Times New Roman', Times, serif; font-size: 8pt; font-weight: bold; margin-top: 0pt; margin-left: 0pt; text-align: left;">10,853,629</div> </td> </tr> </table> <table border="0" cellpadding="0" cellspacing="0" style="margin-top: 3pt; margin-left: 0pt;"> <tr> <td style="width: 20pt; text-align: left; vertical-align: top;"> <div style="color: #000000; font-family: 'Times New Roman', Times, serif; font-size: 8pt;">(3)<br/> </div> </td> <td style="vertical-align: top;"> <div style="color: #000000; font-family: 'Times New Roman', Times, serif; font-size: 8pt; text-align: justify;">These amounts represent the average of the amounts reported for the Company’s named executive officers (referred to as “NEOs” in this section) as a group (excluding Mr. Stonehouse) in the “Total” column of the Summary Compensation Table in each applicable year. The names of each of the NEOs included for these purposes in each applicable year are as follows: (i) for 2022, Mr. Doyle, Dr. Thackray, Ms. Barnes, Mr. Gayer, Dr. Babu, and Dr. Sheridan; (ii) for 2021, Mr. Doyle, Dr. Thackray, Dr. Babu, Dr. Sheridan, and Megan T. Sniecinski, the Company’s former Chief Business Officer; and (iii) for 2020, Thomas R. Staab II, the Company’s former CFO, Mr. Doyle, Dr. Babu, Dr. Sheridan, and Ms. Sniecinski. Refer to the “2021 Summary Compensation Table” and “2020 Summary Compensation Table” in our proxy statements for our 2022 and 2021 annual stockholder meetings, respectively, for additional information regarding our NEOs for 2021 and 2020, respectively. </div> </td> </tr> </table> <table border="0" cellpadding="0" cellspacing="0" style="margin-top: 3pt; margin-left: 0pt;"> <tr> <td style="width: 20pt; text-align: left; vertical-align: top;"> <div style="color: #000000; font-family: 'Times New Roman', Times, serif; font-size: 8pt;">(4)<br/> </div> </td> <td style="vertical-align: top;"> <div style="color: #000000; font-family: 'Times New Roman', Times, serif; font-size: 8pt; text-align: justify;">These amounts represent the average amount of “compensation actually paid” to the NEOs identified in note 3 above as a group, as computed in accordance with Item 402(v) of Regulation S-K and do not reflect the average of the total compensation actually realized or received by these NEOs. In accordance with these rules, these amounts reflect “Total Compensation” as set forth in the respective Summary Compensation Table for each year, adjusted as shown below. Equity values are calculated in accordance with FASB ASC Topic 718, and the valuation assumptions used to calculate fair values did not materially differ from those disclosed at the time of the grant.</div> </td> </tr> </table> <table cellpadding="0" cellspacing="0" class="fintab" style="margin-top: 4pt; border-collapse: collapse; width: 448pt; margin-left: 20pt;"> <tr class="header"> <td style="width: 69.64%; text-align: center; vertical-align: bottom; border-bottom: 1pt solid #000000; padding-top: 6pt; padding-bottom: 4.25pt;"> <div class="fpara" style="color: #000000; font-family: 'Times New Roman', Times, serif; font-size: 8pt; font-weight: bold; margin-top: 0pt; text-align: center;">Average Compensation Actually Paid to Non-PEO NEOs</div> </td> <td class="gutter" style="width: 1.19%; font-size: 2pt; padding-top: 6pt; padding-bottom: 4.25pt; border-bottom: 1px solid #ffffff;">​</td> <td class="gutter" style="width: 1.19%; font-size: 2pt; padding-top: 6pt; padding-bottom: 4.25pt; border-bottom: 1px solid #ffffff;">​</td> <td style="width: 7.74%; text-align: center; vertical-align: bottom; border-bottom: 1pt solid #000000; padding-top: 6pt; padding-bottom: 4.25pt;"> <div class="fpara" style="color: #000000; font-family: 'Times New Roman', Times, serif; font-size: 8pt; font-weight: bold; margin-top: 0pt; text-align: center;">2022</div> </td> <td class="gutter" style="width: 1.19%; font-size: 2pt; padding-top: 6pt; padding-bottom: 4.25pt; border-bottom: 1px solid #ffffff;">​</td> <td class="gutter" style="width: 1.19%; font-size: 2pt; padding-top: 6pt; padding-bottom: 4.25pt; border-bottom: 1px solid #ffffff;">​</td> <td style="width: 7.74%; text-align: center; vertical-align: bottom; border-bottom: 1pt solid #000000; padding-top: 6pt; padding-bottom: 4.25pt;"> <div class="fpara" style="color: #000000; font-family: 'Times New Roman', Times, serif; font-size: 8pt; font-weight: bold; margin-top: 0pt; text-align: center;">2021</div> </td> <td class="gutter" style="width: 1.19%; font-size: 2pt; padding-top: 6pt; padding-bottom: 4.25pt; border-bottom: 1px solid #ffffff;">​</td> <td class="gutter" style="width: 1.19%; font-size: 2pt; padding-top: 6pt; padding-bottom: 4.25pt; border-bottom: 1px solid #ffffff;">​</td> <td style="width: 7.74%; text-align: center; vertical-align: bottom; border-bottom: 1pt solid #000000; padding-top: 6pt; padding-bottom: 4.25pt;"> <div class="fpara" style="color: #000000; font-family: 'Times New Roman', Times, serif; font-size: 8pt; font-weight: bold; margin-top: 0pt; text-align: center;">2020</div> </td> </tr> <tr> <td style="width: 69.64%; text-align: left; vertical-align: bottom; padding-top: 4.25pt; padding-bottom: 3pt; background-color: #CCEEFF;"> <div class="fpara" style="color: #000000; font-family: 'Times New Roman', Times, serif; font-size: 8pt; margin-top: 0pt; margin-left: 0pt; text-align: left;">Average Summary Compensation Table Total</div> </td> <td class="gutter" style="width: 1.19%; border-bottom: none; font-size: 2pt; padding-top: 4.25pt; padding-bottom: 3pt; background-color: #CCEEFF;">​</td> <td class="gutter" style="width: 1.19%; border-bottom: none; font-size: 2pt; padding-top: 4.25pt; padding-bottom: 3pt; background-color: #CCEEFF;">​</td> <td style="width: 7.74%; text-align: left; vertical-align: bottom; white-space: nowrap; padding-top: 4.25pt; padding-bottom: 3pt; background-color: #CCEEFF;"> <div class="fpara" style="color: #000000; font-family: 'Times New Roman', Times, serif; font-size: 8pt; margin-top: 0pt; margin-left: -0.01pt; text-align: left;"><span style="padding-left: 2.66pt;">2,568,935</span></div> </td> <td class="gutter" style="width: 1.19%; border-bottom: none; font-size: 2pt; padding-top: 4.25pt; padding-bottom: 3pt; background-color: #CCEEFF;">​</td> <td class="gutter" style="width: 1.19%; border-bottom: none; font-size: 2pt; padding-top: 4.25pt; padding-bottom: 3pt; background-color: #CCEEFF;">​</td> <td style="width: 7.74%; text-align: left; vertical-align: bottom; white-space: nowrap; padding-top: 4.25pt; padding-bottom: 3pt; background-color: #CCEEFF;"> <div class="fpara" style="color: #000000; font-family: 'Times New Roman', Times, serif; font-size: 8pt; margin-top: 0pt; margin-left: 0.01pt; text-align: left;"><span style="padding-left: 2.66pt;">4,523,739</span></div> </td> <td class="gutter" style="width: 1.19%; border-bottom: none; font-size: 2pt; padding-top: 4.25pt; padding-bottom: 3pt; background-color: #CCEEFF;">​</td> <td class="gutter" style="width: 1.19%; border-bottom: none; font-size: 2pt; padding-top: 4.25pt; padding-bottom: 3pt; background-color: #CCEEFF;">​</td> <td style="width: 7.74%; text-align: left; vertical-align: bottom; white-space: nowrap; padding-top: 4.25pt; padding-bottom: 3pt; background-color: #CCEEFF;"> <div class="fpara" style="color: #000000; font-family: 'Times New Roman', Times, serif; font-size: 8pt; margin-top: 0pt; margin-left: 0.01pt; text-align: left;"><span style="padding-left: 2.66pt;">2,353,552</span></div> </td> </tr> <tr> <td style="width: 69.64%; text-align: left; vertical-align: bottom; padding-top: 3pt; padding-bottom: 3pt;"> <div class="fpara" style="color: #000000; font-family: 'Times New Roman', Times, serif; font-size: 8pt; margin-top: 0pt; margin-left: 20pt; text-indent: -10pt; text-align: left;">Less, average value of “Stock Awards” and “Option Awards” reported in Summary Compensation Table</div> </td> <td class="gutter" style="width: 1.19%; border-bottom: none; font-size: 2pt; padding-top: 3pt; padding-bottom: 3pt;">​</td> <td class="gutter" style="width: 1.19%; border-bottom: none; font-size: 2pt; padding-top: 3pt; padding-bottom: 3pt;">​</td> <td style="width: 7.74%; text-align: left; vertical-align: bottom; white-space: nowrap; padding-top: 3pt; padding-bottom: 3pt;"> <div class="fpara" style="color: #000000; font-family: 'Times New Roman', Times, serif; font-size: 8pt; margin-top: 0pt; margin-left: -0.01pt; text-align: left;">(1,844,815)</div> </td> <td class="gutter" style="width: 1.19%; border-bottom: none; font-size: 2pt; padding-top: 3pt; padding-bottom: 3pt;">​</td> <td class="gutter" style="width: 1.19%; border-bottom: none; font-size: 2pt; padding-top: 3pt; padding-bottom: 3pt;">​</td> <td style="width: 7.74%; text-align: left; vertical-align: bottom; white-space: nowrap; padding-top: 3pt; padding-bottom: 3pt;"> <div class="fpara" style="color: #000000; font-family: 'Times New Roman', Times, serif; font-size: 8pt; margin-top: 0pt; margin-left: 0.01pt; text-align: left;">(3,677,542)</div> </td> <td class="gutter" style="width: 1.19%; border-bottom: none; font-size: 2pt; padding-top: 3pt; padding-bottom: 3pt;">​</td> <td class="gutter" style="width: 1.19%; border-bottom: none; font-size: 2pt; padding-top: 3pt; padding-bottom: 3pt;">​</td> <td style="width: 7.74%; text-align: left; vertical-align: bottom; white-space: nowrap; padding-top: 3pt; padding-bottom: 3pt;"> <div class="fpara" style="color: #000000; font-family: 'Times New Roman', Times, serif; font-size: 8pt; margin-top: 0pt; margin-left: 0.01pt; text-align: left;">(1,642,946)</div> </td> </tr> <tr> <td style="width: 69.64%; text-align: left; vertical-align: bottom; padding-top: 3pt; padding-bottom: 3pt; background-color: #CCEEFF;"> <div class="fpara" style="color: #000000; font-family: 'Times New Roman', Times, serif; font-size: 8pt; margin-top: 0pt; margin-left: 20pt; text-indent: -10pt; text-align: left;">Plus, average year-end fair value of outstanding and unvested equity awards granted in the year</div> </td> <td class="gutter" style="width: 1.19%; border-bottom: none; font-size: 2pt; padding-top: 3pt; padding-bottom: 3pt; background-color: #CCEEFF;">​</td> <td class="gutter" style="width: 1.19%; border-bottom: none; font-size: 2pt; padding-top: 3pt; padding-bottom: 3pt; background-color: #CCEEFF;">​</td> <td style="width: 7.74%; text-align: left; vertical-align: bottom; white-space: nowrap; padding-top: 3pt; padding-bottom: 3pt; background-color: #CCEEFF;"> <div class="fpara" style="color: #000000; font-family: 'Times New Roman', Times, serif; font-size: 8pt; margin-top: 0pt; margin-left: -0.01pt; text-align: left;"><span style="padding-left: 2.66pt;">2,020,092</span></div> </td> <td class="gutter" style="width: 1.19%; border-bottom: none; font-size: 2pt; padding-top: 3pt; padding-bottom: 3pt; background-color: #CCEEFF;">​</td> <td class="gutter" style="width: 1.19%; border-bottom: none; font-size: 2pt; padding-top: 3pt; padding-bottom: 3pt; background-color: #CCEEFF;">​</td> <td style="width: 7.74%; text-align: left; vertical-align: bottom; white-space: nowrap; padding-top: 3pt; padding-bottom: 3pt; background-color: #CCEEFF;"> <div class="fpara" style="color: #000000; font-family: 'Times New Roman', Times, serif; font-size: 8pt; margin-top: 0pt; margin-left: 0.01pt; text-align: left;"><span style="padding-left: 2.66pt;">2,998,786</span></div> </td> <td class="gutter" style="width: 1.19%; border-bottom: none; font-size: 2pt; padding-top: 3pt; padding-bottom: 3pt; background-color: #CCEEFF;">​</td> <td class="gutter" style="width: 1.19%; border-bottom: none; font-size: 2pt; padding-top: 3pt; padding-bottom: 3pt; background-color: #CCEEFF;">​</td> <td style="width: 7.74%; text-align: left; vertical-align: bottom; white-space: nowrap; padding-top: 3pt; padding-bottom: 3pt; background-color: #CCEEFF;"> <div class="fpara" style="color: #000000; font-family: 'Times New Roman', Times, serif; font-size: 8pt; margin-top: 0pt; margin-left: 0.01pt; text-align: left;"><span style="padding-left: 2.66pt;">1,849,354</span></div> </td> </tr> <tr> <td style="width: 69.64%; text-align: left; vertical-align: bottom; padding-top: 3pt; padding-bottom: 3pt;"> <div class="fpara" style="color: #000000; font-family: 'Times New Roman', Times, serif; font-size: 8pt; margin-top: 0pt; margin-left: 20pt; text-indent: -10pt; text-align: left;">Plus (less), average year-over-year change in fair value of outstanding and unvested equity awards granted in prior years</div> </td> <td class="gutter" style="width: 1.19%; border-bottom: none; font-size: 2pt; padding-top: 3pt; padding-bottom: 3pt;">​</td> <td class="gutter" style="width: 1.19%; border-bottom: none; font-size: 2pt; padding-top: 3pt; padding-bottom: 3pt;">​</td> <td style="width: 7.74%; text-align: left; vertical-align: bottom; white-space: nowrap; padding-top: 3pt; padding-bottom: 3pt;"> <div class="fpara" style="color: #000000; font-family: 'Times New Roman', Times, serif; font-size: 8pt; margin-top: 0pt; margin-left: -0.01pt; text-align: left;"><span style="padding-left: 6pt;">(813,831)</span></div> </td> <td class="gutter" style="width: 1.19%; border-bottom: none; font-size: 2pt; padding-top: 3pt; padding-bottom: 3pt;">​</td> <td class="gutter" style="width: 1.19%; border-bottom: none; font-size: 2pt; padding-top: 3pt; padding-bottom: 3pt;">​</td> <td style="width: 7.74%; text-align: left; vertical-align: bottom; white-space: nowrap; padding-top: 3pt; padding-bottom: 3pt;"> <div class="fpara" style="color: #000000; font-family: 'Times New Roman', Times, serif; font-size: 8pt; margin-top: 0pt; margin-left: 0.01pt; text-align: left;"><span style="padding-left: 2.66pt;">1,691,604</span></div> </td> <td class="gutter" style="width: 1.19%; border-bottom: none; font-size: 2pt; padding-top: 3pt; padding-bottom: 3pt;">​</td> <td class="gutter" style="width: 1.19%; border-bottom: none; font-size: 2pt; padding-top: 3pt; padding-bottom: 3pt;">​</td> <td style="width: 7.74%; text-align: left; vertical-align: bottom; white-space: nowrap; padding-top: 3pt; padding-bottom: 3pt;"> <div class="fpara" style="color: #000000; font-family: 'Times New Roman', Times, serif; font-size: 8pt; margin-top: 0pt; margin-left: 0.01pt; text-align: left;"><span style="padding-left: 8.66pt;">871,718</span></div> </td> </tr> <tr> <td style="width: 69.64%; text-align: left; vertical-align: bottom; padding-top: 3pt; padding-bottom: 3pt; background-color: #CCEEFF;"> <div class="fpara" style="color: #000000; font-family: 'Times New Roman', Times, serif; font-size: 8pt; margin-top: 0pt; margin-left: 20pt; text-indent: -10pt; text-align: left;">Plus (less), average year-over-year change in fair value (from the end of the prior year through the vesting date) of equity awards granted in prior years that vested in the year</div> </td> <td class="gutter" style="width: 1.19%; border-bottom: none; font-size: 2pt; padding-top: 3pt; padding-bottom: 3pt; background-color: #CCEEFF;">​</td> <td class="gutter" style="width: 1.19%; border-bottom: none; font-size: 2pt; padding-top: 3pt; padding-bottom: 3pt; background-color: #CCEEFF;">​</td> <td style="width: 7.74%; text-align: left; vertical-align: bottom; white-space: nowrap; padding-top: 3pt; padding-bottom: 3pt; background-color: #CCEEFF;"> <div class="fpara" style="color: #000000; font-family: 'Times New Roman', Times, serif; font-size: 8pt; margin-top: 0pt; margin-left: -0.01pt; text-align: left;"><span style="padding-left: 6pt;">(477,748)</span></div> </td> <td class="gutter" style="width: 1.19%; border-bottom: none; font-size: 2pt; padding-top: 3pt; padding-bottom: 3pt; background-color: #CCEEFF;">​</td> <td class="gutter" style="width: 1.19%; border-bottom: none; font-size: 2pt; padding-top: 3pt; padding-bottom: 3pt; background-color: #CCEEFF;">​</td> <td style="width: 7.74%; text-align: left; vertical-align: bottom; white-space: nowrap; padding-top: 3pt; padding-bottom: 3pt; background-color: #CCEEFF;"> <div class="fpara" style="color: #000000; font-family: 'Times New Roman', Times, serif; font-size: 8pt; margin-top: 0pt; margin-left: 0.01pt; text-align: left;"><span style="padding-left: 2.66pt;">1,773,047</span></div> </td> <td class="gutter" style="width: 1.19%; border-bottom: none; font-size: 2pt; padding-top: 3pt; padding-bottom: 3pt; background-color: #CCEEFF;">​</td> <td class="gutter" style="width: 1.19%; border-bottom: none; font-size: 2pt; padding-top: 3pt; padding-bottom: 3pt; background-color: #CCEEFF;">​</td> <td style="width: 7.74%; text-align: left; vertical-align: bottom; white-space: nowrap; padding-top: 3pt; padding-bottom: 3pt; background-color: #CCEEFF;"> <div class="fpara" style="color: #000000; font-family: 'Times New Roman', Times, serif; font-size: 8pt; margin-top: 0pt; margin-left: 0.01pt; text-align: left;"><span style="padding-left: 8.66pt;">363,631</span></div> </td> </tr> <tr> <td style="width: 69.64%; text-align: left; vertical-align: bottom; padding-top: 3pt; padding-bottom: 3pt;"> <div class="fpara" style="color: #000000; font-family: 'Times New Roman', Times, serif; font-size: 8pt; margin-top: 0pt; margin-left: 10pt; text-align: left;">Less, average prior year-end fair value for any equity awards forfeited in the year</div> </td> <td class="gutter" style="width: 1.19%; border-bottom: none; font-size: 2pt; padding-top: 3pt; padding-bottom: 3pt;">​</td> <td class="gutter" style="width: 1.19%; border-bottom: none; font-size: 2pt; padding-top: 3pt; padding-bottom: 3pt;">​</td> <td style="width: 7.74%; text-align: left; vertical-align: bottom; white-space: nowrap; padding-top: 3pt; padding-bottom: 3pt;"> <div class="fpara" style="color: #000000; font-family: 'Times New Roman', Times, serif; font-size: 8pt; margin-top: 0pt; margin-left: -0.01pt; text-align: left;"><span style="padding-left: 26.66pt;">—</span></div> </td> <td class="gutter" style="width: 1.19%; border-bottom: none; font-size: 2pt; padding-top: 3pt; padding-bottom: 3pt;">​</td> <td class="gutter" style="width: 1.19%; border-bottom: none; font-size: 2pt; padding-top: 3pt; padding-bottom: 3pt;">​</td> <td style="width: 7.74%; text-align: left; vertical-align: bottom; white-space: nowrap; padding-top: 3pt; padding-bottom: 3pt;"> <div class="fpara" style="color: #000000; font-family: 'Times New Roman', Times, serif; font-size: 8pt; margin-top: 0pt; margin-left: 0.01pt; text-align: left;"><span style="padding-left: 10pt;">(55,492)</span></div> </td> <td class="gutter" style="width: 1.19%; border-bottom: none; font-size: 2pt; padding-top: 3pt; padding-bottom: 3pt;">​</td> <td class="gutter" style="width: 1.19%; border-bottom: none; font-size: 2pt; padding-top: 3pt; padding-bottom: 3pt;">​</td> <td style="width: 7.74%; text-align: left; vertical-align: bottom; white-space: nowrap; padding-top: 3pt; padding-bottom: 3pt;"> <div class="fpara" style="color: #000000; font-family: 'Times New Roman', Times, serif; font-size: 8pt; margin-top: 0pt; margin-left: 0.01pt; text-align: left;"><span style="padding-left: 6pt;">(165,096)</span></div> </td> </tr> <tr> <td style="width: 69.64%; text-align: left; vertical-align: bottom; padding-top: 3pt; padding-bottom: 3pt; background-color: #CCEEFF;"> <div class="fpara" style="color: #000000; font-family: 'Times New Roman', Times, serif; font-size: 8pt; font-weight: bold; margin-top: 0pt; margin-left: 0pt; text-align: left;">Average Compensation Actually Paid to Non-PEO NEOs</div> </td> <td class="gutter" style="width: 1.19%; border-bottom: none; font-size: 2pt; padding-top: 3pt; padding-bottom: 3pt; background-color: #CCEEFF;">​</td> <td class="gutter" style="width: 1.19%; border-bottom: none; font-size: 2pt; padding-top: 3pt; padding-bottom: 3pt; background-color: #CCEEFF;">​</td> <td style="width: 7.74%; text-align: left; vertical-align: bottom; white-space: nowrap; padding-top: 3pt; padding-bottom: 3pt; background-color: #CCEEFF;"> <div class="fpara" style="color: #000000; font-family: 'Times New Roman', Times, serif; font-size: 8pt; font-weight: bold; margin-top: 0pt; margin-left: -0.01pt; text-align: left;"><span style="padding-left: 2.66pt;">1,452,633</span></div> </td> <td class="gutter" style="width: 1.19%; border-bottom: none; font-size: 2pt; padding-top: 3pt; padding-bottom: 3pt; background-color: #CCEEFF;">​</td> <td class="gutter" style="width: 1.19%; border-bottom: none; font-size: 2pt; padding-top: 3pt; padding-bottom: 3pt; background-color: #CCEEFF;">​</td> <td style="width: 7.74%; text-align: left; vertical-align: bottom; white-space: nowrap; padding-top: 3pt; padding-bottom: 3pt; background-color: #CCEEFF;"> <div class="fpara" style="color: #000000; font-family: 'Times New Roman', Times, serif; font-size: 8pt; font-weight: bold; margin-top: 0pt; margin-left: 0.01pt; text-align: left;"><span style="padding-left: 2.66pt;">7,254,142</span></div> </td> <td class="gutter" style="width: 1.19%; border-bottom: none; font-size: 2pt; padding-top: 3pt; padding-bottom: 3pt; background-color: #CCEEFF;">​</td> <td class="gutter" style="width: 1.19%; border-bottom: none; font-size: 2pt; padding-top: 3pt; padding-bottom: 3pt; background-color: #CCEEFF;">​</td> <td style="width: 7.74%; text-align: left; vertical-align: bottom; white-space: nowrap; padding-top: 3pt; padding-bottom: 3pt; background-color: #CCEEFF;"> <div class="fpara" style="color: #000000; font-family: 'Times New Roman', Times, serif; font-size: 8pt; font-weight: bold; margin-top: 0pt; margin-left: 0.01pt; text-align: left;"><span style="padding-left: 2.66pt;">3,630,213</span></div> </td> </tr> </table> <table border="0" cellpadding="0" cellspacing="0" style="margin-top: 5.25pt; margin-left: 0pt;"> <tr> <td style="width: 20pt; text-align: left; vertical-align: top;"> <div style="color: #000000; font-family: 'Times New Roman', Times, serif; font-size: 8pt;">(5)<br/> </div> </td> <td style="vertical-align: top;"> <div style="color: #000000; font-family: 'Times New Roman', Times, serif; font-size: 8pt; text-align: justify;">Total Stockholder Return (TSR) measures the change in a $100 investment in our Common Stock based on its closing price of $3.45 on December 31, 2019 and its year-end closing price thereafter. TSR is calculated by dividing (a) the difference between the share price of Common Stock at the end of each fiscal year shown and the beginning of the measurement period by (b) the share price of Common Stock at the beginning of the measurement period. The beginning of the measurement period for each applicable year is December 31, 2019. </div> </td> </tr> </table> <table border="0" cellpadding="0" cellspacing="0" style="margin-top: 3pt; margin-left: 0pt;"> <tr> <td style="width: 20pt; text-align: left; vertical-align: top;"> <div style="color: #000000; font-family: 'Times New Roman', Times, serif; font-size: 8pt;">(6)<br/> </div> </td> <td style="vertical-align: top;"> <div style="color: #000000; font-family: 'Times New Roman', Times, serif; font-size: 8pt; text-align: left;">The peer group used for this purpose is the CRSP Total Return Index for Nasdaq Pharmaceutical Stocks.</div> </td> </tr> </table> <table border="0" cellpadding="0" cellspacing="0" style="margin-top: 3pt; margin-left: 0pt;"> <tr> <td style="width: 20pt; text-align: left; vertical-align: top;"> <div style="color: #000000; font-family: 'Times New Roman', Times, serif; font-size: 8pt;">(7)<br/> </div> </td> <td style="vertical-align: top;"> <div style="color: #000000; font-family: 'Times New Roman', Times, serif; font-size: 8pt; text-align: justify;">The dollar amounts reported represent the amount of net loss reflected in the Company’s audited financial statements for the applicable year.</div> </td> </tr> </table> <table border="0" cellpadding="0" cellspacing="0" style="margin-top: 3pt; margin-left: 0pt;"> <tr> <td style="width: 20pt; text-align: left; vertical-align: top;"> <div style="color: #000000; font-family: 'Times New Roman', Times, serif; font-size: 8pt;">(8)<br/> </div> </td> <td style="vertical-align: top;"> <div style="color: #000000; font-family: 'Times New Roman', Times, serif; font-size: 8pt; text-align: justify;">Item 402(v)(2)(vi) of Regulation S-K requires that we designate a “Company-Selected Measure,” which, in our assessment, represents the most important financial performance measure (that is not otherwise required to be disclosed in the “Pay Versus Performance” table) used to link “compensation actually paid” to our NEOs, for the most recently completed fiscal year, to Company performance. For these purposes, we have selected ORLADEYO sales. The numbers in this column represent product sales of ORLADEYO and do not include royalty revenue from sales of ORLADEYO in Japan by our collaborative partner, Torii Pharmaceutical Co., Ltd. ORLADEYO is an oral, once-daily therapy discovered and developed by us for the prevention of hereditary angioedema attacks. It was first approved by the U.S. Food and Drug Administration in December 2020, and we began shipping it to patients with a prescription in the United States that same month.</div> </td> </tr> </table> ORLADEYO Sales 6982994 4009070 2568935 1452633 332.75 153.08 -247116000 249689000 7061225 17053230 4523739 7254142 401.45 137.47 -184062000 121865000 6034941 10853629 2353552 3630213 215.94 110.52 -182814000 133000 Jon P. Stonehouse Jon P. Stonehouse Jon P. Stonehouse <table border="0" cellpadding="0" cellspacing="0" style="margin-top: 3pt; margin-left: 0pt;"> <tr> <td style="width: 20pt; text-align: left; vertical-align: top;"> <div style="color: #000000; font-family: 'Times New Roman', Times, serif; font-size: 8pt;">(2)<br/> </div> </td> <td style="vertical-align: top;"> <div style="color: #000000; font-family: 'Times New Roman', Times, serif; font-size: 8pt; text-align: justify;">These amounts represent the amount of “compensation actually paid” to Mr. Stonehouse, as computed in accordance with Item 402(v) of Regulation S-K, and do not reflect the total compensation actually realized or received by Mr. Stonehouse. In accordance with these rules, these amounts reflect total compensation as set forth in the Summary Compensation Table for each year, adjusted as shown below. Equity values are calculated in accordance with FASB ASC Topic 718, and the valuation assumptions used to calculate fair values did not materially differ from those disclosed at the time of grant.</div> </td> </tr> </table> <table cellpadding="0" cellspacing="0" class="fintab" style="margin-top: 4pt; border-collapse: collapse; width: 448pt; margin-left: 20pt;"> <tr class="header"> <td style="width: 66.96%; text-align: center; vertical-align: bottom; border-bottom: 1pt solid #000000; padding-top: 6pt; padding-bottom: 3.25pt;"> <div class="fpara" style="color: #000000; font-family: 'Times New Roman', Times, serif; font-size: 8pt; font-weight: bold; margin-top: 0pt; text-align: center;">Compensation Actually Paid to PEO</div> </td> <td class="gutter" style="width: 1.54%; font-size: 2pt; padding-top: 6pt; padding-bottom: 3.25pt; border-bottom: 1px solid #ffffff;">​</td> <td class="gutter" style="width: 1.54%; font-size: 2pt; padding-top: 6pt; padding-bottom: 3.25pt; border-bottom: 1px solid #ffffff;">​</td> <td style="width: 7.74%; text-align: center; vertical-align: bottom; border-bottom: 1pt solid #000000; padding-top: 6pt; padding-bottom: 3.25pt;"> <div class="fpara" style="color: #000000; font-family: 'Times New Roman', Times, serif; font-size: 8pt; font-weight: bold; margin-top: 0pt; text-align: center;">2022</div> </td> <td class="gutter" style="width: 1.54%; font-size: 2pt; padding-top: 6pt; padding-bottom: 3.25pt; border-bottom: 1px solid #ffffff;">​</td> <td class="gutter" style="width: 1.54%; font-size: 2pt; padding-top: 6pt; padding-bottom: 3.25pt; border-bottom: 1px solid #ffffff;">​</td> <td style="width: 8.04%; text-align: center; vertical-align: bottom; border-bottom: 1pt solid #000000; padding-top: 6pt; padding-bottom: 3.25pt;"> <div class="fpara" style="color: #000000; font-family: 'Times New Roman', Times, serif; font-size: 8pt; font-weight: bold; margin-top: 0pt; text-align: center;">2021</div> </td> <td class="gutter" style="width: 1.54%; font-size: 2pt; padding-top: 6pt; padding-bottom: 3.25pt; border-bottom: 1px solid #ffffff;">​</td> <td class="gutter" style="width: 1.54%; font-size: 2pt; padding-top: 6pt; padding-bottom: 3.25pt; border-bottom: 1px solid #ffffff;">​</td> <td style="width: 8.04%; text-align: center; vertical-align: bottom; border-bottom: 1pt solid #000000; padding-top: 6pt; padding-bottom: 3.25pt;"> <div class="fpara" style="color: #000000; font-family: 'Times New Roman', Times, serif; font-size: 8pt; font-weight: bold; margin-top: 0pt; text-align: center;">2020</div> </td> </tr> <tr> <td style="width: 66.96%; text-align: left; vertical-align: bottom; padding-top: 3.25pt; padding-bottom: 2pt; background-color: #CCEEFF;"> <div class="fpara" style="color: #000000; font-family: 'Times New Roman', Times, serif; font-size: 8pt; margin-top: 0pt; margin-left: 0pt; text-align: left;">Summary Compensation Table Total</div> </td> <td class="gutter" style="width: 1.54%; border-bottom: none; font-size: 2pt; padding-top: 3.25pt; padding-bottom: 2pt; background-color: #CCEEFF;">​</td> <td class="gutter" style="width: 1.54%; border-bottom: none; font-size: 2pt; padding-top: 3.25pt; padding-bottom: 2pt; background-color: #CCEEFF;">​</td> <td style="width: 7.74%; text-align: left; vertical-align: bottom; white-space: nowrap; padding-top: 3.25pt; padding-bottom: 2pt; background-color: #CCEEFF;"> <div class="fpara" style="color: #000000; font-family: 'Times New Roman', Times, serif; font-size: 8pt; margin-top: 0pt; margin-left: 0pt; text-align: left;"><span style="padding-left: 2.66pt;">6,982,994</span></div> </td> <td class="gutter" style="width: 1.54%; border-bottom: none; font-size: 2pt; padding-top: 3.25pt; padding-bottom: 2pt; background-color: #CCEEFF;">​</td> <td class="gutter" style="width: 1.54%; border-bottom: none; font-size: 2pt; padding-top: 3.25pt; padding-bottom: 2pt; background-color: #CCEEFF;">​</td> <td style="width: 8.04%; text-align: left; vertical-align: bottom; white-space: nowrap; padding-top: 3.25pt; padding-bottom: 2pt; background-color: #CCEEFF;"> <div class="fpara" style="color: #000000; font-family: 'Times New Roman', Times, serif; font-size: 8pt; margin-top: 0pt; margin-left: 0pt; text-align: left;"><span style="padding-left: 4pt;">7,061,225</span></div> </td> <td class="gutter" style="width: 1.54%; border-bottom: none; font-size: 2pt; padding-top: 3.25pt; padding-bottom: 2pt; background-color: #CCEEFF;">​</td> <td class="gutter" style="width: 1.54%; border-bottom: none; font-size: 2pt; padding-top: 3.25pt; padding-bottom: 2pt; background-color: #CCEEFF;">​</td> <td style="width: 8.04%; text-align: left; vertical-align: bottom; white-space: nowrap; padding-top: 3.25pt; padding-bottom: 2pt; background-color: #CCEEFF;"> <div class="fpara" style="color: #000000; font-family: 'Times New Roman', Times, serif; font-size: 8pt; margin-top: 0pt; margin-left: 0pt; text-align: left;"><span style="padding-left: 4pt;">6,034,941</span></div> </td> </tr> <tr> <td style="width: 66.96%; text-align: left; vertical-align: bottom; padding-top: 2pt; padding-bottom: 2pt;"> <div class="fpara" style="color: #000000; font-family: 'Times New Roman', Times, serif; font-size: 8pt; margin-top: 0pt; margin-left: 20pt; text-indent: -10pt; text-align: left;">(Less), value of “Stock Awards” and “Option Awards” reported in Summary Compensation Table</div> </td> <td class="gutter" style="width: 1.54%; border-bottom: none; font-size: 2pt; padding-top: 2pt; padding-bottom: 2pt;">​</td> <td class="gutter" style="width: 1.54%; border-bottom: none; font-size: 2pt; padding-top: 2pt; padding-bottom: 2pt;">​</td> <td style="width: 7.74%; text-align: left; vertical-align: bottom; white-space: nowrap; padding-top: 2pt; padding-bottom: 2pt;"> <div class="fpara" style="color: #000000; font-family: 'Times New Roman', Times, serif; font-size: 8pt; margin-top: 0pt; margin-left: 0pt; text-align: left;">(5,837,579)</div> </td> <td class="gutter" style="width: 1.54%; border-bottom: none; font-size: 2pt; padding-top: 2pt; padding-bottom: 2pt;">​</td> <td class="gutter" style="width: 1.54%; border-bottom: none; font-size: 2pt; padding-top: 2pt; padding-bottom: 2pt;">​</td> <td style="width: 8.04%; text-align: left; vertical-align: bottom; white-space: nowrap; padding-top: 2pt; padding-bottom: 2pt;"> <div class="fpara" style="color: #000000; font-family: 'Times New Roman', Times, serif; font-size: 8pt; margin-top: 0pt; margin-left: 0pt; text-align: left;"><span style="padding-left: 1.34pt;">(5,916,979)</span></div> </td> <td class="gutter" style="width: 1.54%; border-bottom: none; font-size: 2pt; padding-top: 2pt; padding-bottom: 2pt;">​</td> <td class="gutter" style="width: 1.54%; border-bottom: none; font-size: 2pt; padding-top: 2pt; padding-bottom: 2pt;">​</td> <td style="width: 8.04%; text-align: left; vertical-align: bottom; white-space: nowrap; padding-top: 2pt; padding-bottom: 2pt;"> <div class="fpara" style="color: #000000; font-family: 'Times New Roman', Times, serif; font-size: 8pt; margin-top: 0pt; margin-left: 0pt; text-align: left;"><span style="padding-left: 1.34pt;">(4,916,022)</span></div> </td> </tr> <tr> <td style="width: 66.96%; text-align: left; vertical-align: bottom; padding-top: 2pt; padding-bottom: 2pt; background-color: #CCEEFF;"> <div class="fpara" style="color: #000000; font-family: 'Times New Roman', Times, serif; font-size: 8pt; margin-top: 0pt; margin-left: 10pt; text-align: left;">Plus, year-end fair value of outstanding and unvested equity awards granted in the year</div> </td> <td class="gutter" style="width: 1.54%; border-bottom: none; font-size: 2pt; padding-top: 2pt; padding-bottom: 2pt; background-color: #CCEEFF;">​</td> <td class="gutter" style="width: 1.54%; border-bottom: none; font-size: 2pt; padding-top: 2pt; padding-bottom: 2pt; background-color: #CCEEFF;">​</td> <td style="width: 7.74%; text-align: left; vertical-align: bottom; white-space: nowrap; padding-top: 2pt; padding-bottom: 2pt; background-color: #CCEEFF;"> <div class="fpara" style="color: #000000; font-family: 'Times New Roman', Times, serif; font-size: 8pt; margin-top: 0pt; margin-left: 0pt; text-align: left;"><span style="padding-left: 2.66pt;">6,400,540</span></div> </td> <td class="gutter" style="width: 1.54%; border-bottom: none; font-size: 2pt; padding-top: 2pt; padding-bottom: 2pt; background-color: #CCEEFF;">​</td> <td class="gutter" style="width: 1.54%; border-bottom: none; font-size: 2pt; padding-top: 2pt; padding-bottom: 2pt; background-color: #CCEEFF;">​</td> <td style="width: 8.04%; text-align: left; vertical-align: bottom; white-space: nowrap; padding-top: 2pt; padding-bottom: 2pt; background-color: #CCEEFF;"> <div class="fpara" style="color: #000000; font-family: 'Times New Roman', Times, serif; font-size: 8pt; margin-top: 0pt; margin-left: 0pt; text-align: left;"><span style="padding-left: 4pt;">7,409,280</span></div> </td> <td class="gutter" style="width: 1.54%; border-bottom: none; font-size: 2pt; padding-top: 2pt; padding-bottom: 2pt; background-color: #CCEEFF;">​</td> <td class="gutter" style="width: 1.54%; border-bottom: none; font-size: 2pt; padding-top: 2pt; padding-bottom: 2pt; background-color: #CCEEFF;">​</td> <td style="width: 8.04%; text-align: left; vertical-align: bottom; white-space: nowrap; padding-top: 2pt; padding-bottom: 2pt; background-color: #CCEEFF;"> <div class="fpara" style="color: #000000; font-family: 'Times New Roman', Times, serif; font-size: 8pt; margin-top: 0pt; margin-left: 0pt; text-align: left;"><span style="padding-left: 4pt;">4,291,310</span></div> </td> </tr> <tr> <td style="width: 66.96%; text-align: left; vertical-align: bottom; padding-top: 2pt; padding-bottom: 2pt;"> <div class="fpara" style="color: #000000; font-family: 'Times New Roman', Times, serif; font-size: 8pt; margin-top: 0pt; margin-left: 20pt; text-indent: -10pt; text-align: left;">Plus (less), year-over-year change in fair value of outstanding and unvested equity awards granted in prior years</div> </td> <td class="gutter" style="width: 1.54%; border-bottom: none; font-size: 2pt; padding-top: 2pt; padding-bottom: 2pt;">​</td> <td class="gutter" style="width: 1.54%; border-bottom: none; font-size: 2pt; padding-top: 2pt; padding-bottom: 2pt;">​</td> <td style="width: 7.74%; text-align: left; vertical-align: bottom; white-space: nowrap; padding-top: 2pt; padding-bottom: 2pt;"> <div class="fpara" style="color: #000000; font-family: 'Times New Roman', Times, serif; font-size: 8pt; margin-top: 0pt; margin-left: 0pt; text-align: left;">(1,953,028)</div> </td> <td class="gutter" style="width: 1.54%; border-bottom: none; font-size: 2pt; padding-top: 2pt; padding-bottom: 2pt;">​</td> <td class="gutter" style="width: 1.54%; border-bottom: none; font-size: 2pt; padding-top: 2pt; padding-bottom: 2pt;">​</td> <td style="width: 8.04%; text-align: left; vertical-align: bottom; white-space: nowrap; padding-top: 2pt; padding-bottom: 2pt;"> <div class="fpara" style="color: #000000; font-family: 'Times New Roman', Times, serif; font-size: 8pt; margin-top: 0pt; margin-left: 0pt; text-align: left;"><span style="padding-left: 4pt;">5,604,968</span></div> </td> <td class="gutter" style="width: 1.54%; border-bottom: none; font-size: 2pt; padding-top: 2pt; padding-bottom: 2pt;">​</td> <td class="gutter" style="width: 1.54%; border-bottom: none; font-size: 2pt; padding-top: 2pt; padding-bottom: 2pt;">​</td> <td style="width: 8.04%; text-align: left; vertical-align: bottom; white-space: nowrap; padding-top: 2pt; padding-bottom: 2pt;"> <div class="fpara" style="color: #000000; font-family: 'Times New Roman', Times, serif; font-size: 8pt; margin-top: 0pt; margin-left: 0pt; text-align: left;"><span style="padding-left: 4pt;">2,621,407</span></div> </td> </tr> <tr> <td style="width: 66.96%; text-align: left; vertical-align: bottom; padding-top: 2pt; padding-bottom: 2pt; background-color: #CCEEFF;"> <div class="fpara" style="color: #000000; font-family: 'Times New Roman', Times, serif; font-size: 8pt; margin-top: 0pt; margin-left: 20pt; text-indent: -10pt; text-align: left;">Plus (less), year-over-year change in fair value (from the end of the prior year through the vesting date) of equity awards granted in prior years that vested in the year</div> </td> <td class="gutter" style="width: 1.54%; border-bottom: none; font-size: 2pt; padding-top: 2pt; padding-bottom: 2pt; background-color: #CCEEFF;">​</td> <td class="gutter" style="width: 1.54%; border-bottom: none; font-size: 2pt; padding-top: 2pt; padding-bottom: 2pt; background-color: #CCEEFF;">​</td> <td style="width: 7.74%; text-align: left; vertical-align: bottom; white-space: nowrap; padding-top: 2pt; padding-bottom: 2pt; background-color: #CCEEFF;"> <div class="fpara" style="color: #000000; font-family: 'Times New Roman', Times, serif; font-size: 8pt; margin-top: 0pt; margin-left: 0pt; text-align: left;">(1,583,857)</div> </td> <td class="gutter" style="width: 1.54%; border-bottom: none; font-size: 2pt; padding-top: 2pt; padding-bottom: 2pt; background-color: #CCEEFF;">​</td> <td class="gutter" style="width: 1.54%; border-bottom: none; font-size: 2pt; padding-top: 2pt; padding-bottom: 2pt; background-color: #CCEEFF;">​</td> <td style="width: 8.04%; text-align: left; vertical-align: bottom; white-space: nowrap; padding-top: 2pt; padding-bottom: 2pt; background-color: #CCEEFF;"> <div class="fpara" style="color: #000000; font-family: 'Times New Roman', Times, serif; font-size: 8pt; margin-top: 0pt; margin-left: 0pt; text-align: left;"><span style="padding-left: 4pt;">2,894,736</span></div> </td> <td class="gutter" style="width: 1.54%; border-bottom: none; font-size: 2pt; padding-top: 2pt; padding-bottom: 2pt; background-color: #CCEEFF;">​</td> <td class="gutter" style="width: 1.54%; border-bottom: none; font-size: 2pt; padding-top: 2pt; padding-bottom: 2pt; background-color: #CCEEFF;">​</td> <td style="width: 8.04%; text-align: left; vertical-align: bottom; white-space: nowrap; padding-top: 2pt; padding-bottom: 2pt; background-color: #CCEEFF;"> <div class="fpara" style="color: #000000; font-family: 'Times New Roman', Times, serif; font-size: 8pt; margin-top: 0pt; margin-left: 0pt; text-align: left;"><span style="padding-left: 4pt;">2,821,993</span></div> </td> </tr> <tr> <td style="width: 66.96%; text-align: left; vertical-align: bottom; padding-top: 2pt; padding-bottom: 3pt;"> <div class="fpara" style="color: #000000; font-family: 'Times New Roman', Times, serif; font-size: 8pt; font-weight: bold; margin-top: 0pt; margin-left: 0pt; text-align: left;">Compensation Actually Paid to Jon P. Stonehouse</div> </td> <td class="gutter" style="width: 1.54%; border-bottom: none; font-size: 2pt; padding-top: 2pt; padding-bottom: 3pt;">​</td> <td class="gutter" style="width: 1.54%; border-bottom: none; font-size: 2pt; padding-top: 2pt; padding-bottom: 3pt;">​</td> <td style="width: 7.74%; text-align: left; vertical-align: bottom; white-space: nowrap; padding-top: 2pt; padding-bottom: 3pt;"> <div class="fpara" style="color: #000000; font-family: 'Times New Roman', Times, serif; font-size: 8pt; font-weight: bold; margin-top: 0pt; margin-left: 0pt; text-align: left;"><span style="padding-left: 2.66pt;">4,009,070</span></div> </td> <td class="gutter" style="width: 1.54%; border-bottom: none; font-size: 2pt; padding-top: 2pt; padding-bottom: 3pt;">​</td> <td class="gutter" style="width: 1.54%; border-bottom: none; font-size: 2pt; padding-top: 2pt; padding-bottom: 3pt;">​</td> <td style="width: 8.04%; text-align: left; vertical-align: bottom; white-space: nowrap; padding-top: 2pt; padding-bottom: 3pt;"> <div class="fpara" style="color: #000000; font-family: 'Times New Roman', Times, serif; font-size: 8pt; font-weight: bold; margin-top: 0pt; margin-left: 0pt; text-align: left;">17,053,230</div> </td> <td class="gutter" style="width: 1.54%; border-bottom: none; font-size: 2pt; padding-top: 2pt; padding-bottom: 3pt;">​</td> <td class="gutter" style="width: 1.54%; border-bottom: none; font-size: 2pt; padding-top: 2pt; padding-bottom: 3pt;">​</td> <td style="width: 8.04%; text-align: left; vertical-align: bottom; white-space: nowrap; padding-top: 2pt; padding-bottom: 3pt;"> <div class="fpara" style="color: #000000; font-family: 'Times New Roman', Times, serif; font-size: 8pt; font-weight: bold; margin-top: 0pt; margin-left: 0pt; text-align: left;">10,853,629</div> </td> </tr> </table> 6982994 7061225 6034941 -5837579 -5916979 -4916022 6400540 7409280 4291310 -1953028 5604968 2621407 -1583857 2894736 2821993 4009070 17053230 10853629 <table border="0" cellpadding="0" cellspacing="0" style="margin-top: 3pt; margin-left: 0pt;"> <tr> <td style="width: 20pt; text-align: left; vertical-align: top;"> <div style="color: #000000; font-family: 'Times New Roman', Times, serif; font-size: 8pt;">(3)<br/> </div> </td> <td style="vertical-align: top;"> <div style="color: #000000; font-family: 'Times New Roman', Times, serif; font-size: 8pt; text-align: justify;">These amounts represent the average of the amounts reported for the Company’s named executive officers (referred to as “NEOs” in this section) as a group (excluding Mr. Stonehouse) in the “Total” column of the Summary Compensation Table in each applicable year. The names of each of the NEOs included for these purposes in each applicable year are as follows: (i) for 2022, Mr. Doyle, Dr. Thackray, Ms. Barnes, Mr. Gayer, Dr. Babu, and Dr. Sheridan; (ii) for 2021, Mr. Doyle, Dr. Thackray, Dr. Babu, Dr. Sheridan, and Megan T. Sniecinski, the Company’s former Chief Business Officer; and (iii) for 2020, Thomas R. Staab II, the Company’s former CFO, Mr. Doyle, Dr. Babu, Dr. Sheridan, and Ms. Sniecinski. Refer to the “2021 Summary Compensation Table” and “2020 Summary Compensation Table” in our proxy statements for our 2022 and 2021 annual stockholder meetings, respectively, for additional information regarding our NEOs for 2021 and 2020, respectively. </div> </td> </tr> </table> <table border="0" cellpadding="0" cellspacing="0" style="margin-top: 3pt; margin-left: 0pt;"> <tr> <td style="width: 20pt; text-align: left; vertical-align: top;"> <div style="color: #000000; font-family: 'Times New Roman', Times, serif; font-size: 8pt;">(4)<br/> </div> </td> <td style="vertical-align: top;"> <div style="color: #000000; font-family: 'Times New Roman', Times, serif; font-size: 8pt; text-align: justify;">These amounts represent the average amount of “compensation actually paid” to the NEOs identified in note 3 above as a group, as computed in accordance with Item 402(v) of Regulation S-K and do not reflect the average of the total compensation actually realized or received by these NEOs. In accordance with these rules, these amounts reflect “Total Compensation” as set forth in the respective Summary Compensation Table for each year, adjusted as shown below. Equity values are calculated in accordance with FASB ASC Topic 718, and the valuation assumptions used to calculate fair values did not materially differ from those disclosed at the time of the grant.</div> </td> </tr> </table> <table cellpadding="0" cellspacing="0" class="fintab" style="margin-top: 4pt; border-collapse: collapse; width: 448pt; margin-left: 20pt;"> <tr class="header"> <td style="width: 69.64%; text-align: center; vertical-align: bottom; border-bottom: 1pt solid #000000; padding-top: 6pt; padding-bottom: 4.25pt;"> <div class="fpara" style="color: #000000; font-family: 'Times New Roman', Times, serif; font-size: 8pt; font-weight: bold; margin-top: 0pt; text-align: center;">Average Compensation Actually Paid to Non-PEO NEOs</div> </td> <td class="gutter" style="width: 1.19%; font-size: 2pt; padding-top: 6pt; padding-bottom: 4.25pt; border-bottom: 1px solid #ffffff;">​</td> <td class="gutter" style="width: 1.19%; font-size: 2pt; padding-top: 6pt; padding-bottom: 4.25pt; border-bottom: 1px solid #ffffff;">​</td> <td style="width: 7.74%; text-align: center; vertical-align: bottom; border-bottom: 1pt solid #000000; padding-top: 6pt; padding-bottom: 4.25pt;"> <div class="fpara" style="color: #000000; font-family: 'Times New Roman', Times, serif; font-size: 8pt; font-weight: bold; margin-top: 0pt; text-align: center;">2022</div> </td> <td class="gutter" style="width: 1.19%; font-size: 2pt; padding-top: 6pt; padding-bottom: 4.25pt; border-bottom: 1px solid #ffffff;">​</td> <td class="gutter" style="width: 1.19%; font-size: 2pt; padding-top: 6pt; padding-bottom: 4.25pt; border-bottom: 1px solid #ffffff;">​</td> <td style="width: 7.74%; text-align: center; vertical-align: bottom; border-bottom: 1pt solid #000000; padding-top: 6pt; padding-bottom: 4.25pt;"> <div class="fpara" style="color: #000000; font-family: 'Times New Roman', Times, serif; font-size: 8pt; font-weight: bold; margin-top: 0pt; text-align: center;">2021</div> </td> <td class="gutter" style="width: 1.19%; font-size: 2pt; padding-top: 6pt; padding-bottom: 4.25pt; border-bottom: 1px solid #ffffff;">​</td> <td class="gutter" style="width: 1.19%; font-size: 2pt; padding-top: 6pt; padding-bottom: 4.25pt; border-bottom: 1px solid #ffffff;">​</td> <td style="width: 7.74%; text-align: center; vertical-align: bottom; border-bottom: 1pt solid #000000; padding-top: 6pt; padding-bottom: 4.25pt;"> <div class="fpara" style="color: #000000; font-family: 'Times New Roman', Times, serif; font-size: 8pt; font-weight: bold; margin-top: 0pt; text-align: center;">2020</div> </td> </tr> <tr> <td style="width: 69.64%; text-align: left; vertical-align: bottom; padding-top: 4.25pt; padding-bottom: 3pt; background-color: #CCEEFF;"> <div class="fpara" style="color: #000000; font-family: 'Times New Roman', Times, serif; font-size: 8pt; margin-top: 0pt; margin-left: 0pt; text-align: left;">Average Summary Compensation Table Total</div> </td> <td class="gutter" style="width: 1.19%; border-bottom: none; font-size: 2pt; padding-top: 4.25pt; padding-bottom: 3pt; background-color: #CCEEFF;">​</td> <td class="gutter" style="width: 1.19%; border-bottom: none; font-size: 2pt; padding-top: 4.25pt; padding-bottom: 3pt; background-color: #CCEEFF;">​</td> <td style="width: 7.74%; text-align: left; vertical-align: bottom; white-space: nowrap; padding-top: 4.25pt; padding-bottom: 3pt; background-color: #CCEEFF;"> <div class="fpara" style="color: #000000; font-family: 'Times New Roman', Times, serif; font-size: 8pt; margin-top: 0pt; margin-left: -0.01pt; text-align: left;"><span style="padding-left: 2.66pt;">2,568,935</span></div> </td> <td class="gutter" style="width: 1.19%; border-bottom: none; font-size: 2pt; padding-top: 4.25pt; padding-bottom: 3pt; background-color: #CCEEFF;">​</td> <td class="gutter" style="width: 1.19%; border-bottom: none; font-size: 2pt; padding-top: 4.25pt; padding-bottom: 3pt; background-color: #CCEEFF;">​</td> <td style="width: 7.74%; text-align: left; vertical-align: bottom; white-space: nowrap; padding-top: 4.25pt; padding-bottom: 3pt; background-color: #CCEEFF;"> <div class="fpara" style="color: #000000; font-family: 'Times New Roman', Times, serif; font-size: 8pt; margin-top: 0pt; margin-left: 0.01pt; text-align: left;"><span style="padding-left: 2.66pt;">4,523,739</span></div> </td> <td class="gutter" style="width: 1.19%; border-bottom: none; font-size: 2pt; padding-top: 4.25pt; padding-bottom: 3pt; background-color: #CCEEFF;">​</td> <td class="gutter" style="width: 1.19%; border-bottom: none; font-size: 2pt; padding-top: 4.25pt; padding-bottom: 3pt; background-color: #CCEEFF;">​</td> <td style="width: 7.74%; text-align: left; vertical-align: bottom; white-space: nowrap; padding-top: 4.25pt; padding-bottom: 3pt; background-color: #CCEEFF;"> <div class="fpara" style="color: #000000; font-family: 'Times New Roman', Times, serif; font-size: 8pt; margin-top: 0pt; margin-left: 0.01pt; text-align: left;"><span style="padding-left: 2.66pt;">2,353,552</span></div> </td> </tr> <tr> <td style="width: 69.64%; text-align: left; vertical-align: bottom; padding-top: 3pt; padding-bottom: 3pt;"> <div class="fpara" style="color: #000000; font-family: 'Times New Roman', Times, serif; font-size: 8pt; margin-top: 0pt; margin-left: 20pt; text-indent: -10pt; text-align: left;">Less, average value of “Stock Awards” and “Option Awards” reported in Summary Compensation Table</div> </td> <td class="gutter" style="width: 1.19%; border-bottom: none; font-size: 2pt; padding-top: 3pt; padding-bottom: 3pt;">​</td> <td class="gutter" style="width: 1.19%; border-bottom: none; font-size: 2pt; padding-top: 3pt; padding-bottom: 3pt;">​</td> <td style="width: 7.74%; text-align: left; vertical-align: bottom; white-space: nowrap; padding-top: 3pt; padding-bottom: 3pt;"> <div class="fpara" style="color: #000000; font-family: 'Times New Roman', Times, serif; font-size: 8pt; margin-top: 0pt; margin-left: -0.01pt; text-align: left;">(1,844,815)</div> </td> <td class="gutter" style="width: 1.19%; border-bottom: none; font-size: 2pt; padding-top: 3pt; padding-bottom: 3pt;">​</td> <td class="gutter" style="width: 1.19%; border-bottom: none; font-size: 2pt; padding-top: 3pt; padding-bottom: 3pt;">​</td> <td style="width: 7.74%; text-align: left; vertical-align: bottom; white-space: nowrap; padding-top: 3pt; padding-bottom: 3pt;"> <div class="fpara" style="color: #000000; font-family: 'Times New Roman', Times, serif; font-size: 8pt; margin-top: 0pt; margin-left: 0.01pt; text-align: left;">(3,677,542)</div> </td> <td class="gutter" style="width: 1.19%; border-bottom: none; font-size: 2pt; padding-top: 3pt; padding-bottom: 3pt;">​</td> <td class="gutter" style="width: 1.19%; border-bottom: none; font-size: 2pt; padding-top: 3pt; padding-bottom: 3pt;">​</td> <td style="width: 7.74%; text-align: left; vertical-align: bottom; white-space: nowrap; padding-top: 3pt; padding-bottom: 3pt;"> <div class="fpara" style="color: #000000; font-family: 'Times New Roman', Times, serif; font-size: 8pt; margin-top: 0pt; margin-left: 0.01pt; text-align: left;">(1,642,946)</div> </td> </tr> <tr> <td style="width: 69.64%; text-align: left; vertical-align: bottom; padding-top: 3pt; padding-bottom: 3pt; background-color: #CCEEFF;"> <div class="fpara" style="color: #000000; font-family: 'Times New Roman', Times, serif; font-size: 8pt; margin-top: 0pt; margin-left: 20pt; text-indent: -10pt; text-align: left;">Plus, average year-end fair value of outstanding and unvested equity awards granted in the year</div> </td> <td class="gutter" style="width: 1.19%; border-bottom: none; font-size: 2pt; padding-top: 3pt; padding-bottom: 3pt; background-color: #CCEEFF;">​</td> <td class="gutter" style="width: 1.19%; border-bottom: none; font-size: 2pt; padding-top: 3pt; padding-bottom: 3pt; background-color: #CCEEFF;">​</td> <td style="width: 7.74%; text-align: left; vertical-align: bottom; white-space: nowrap; padding-top: 3pt; padding-bottom: 3pt; background-color: #CCEEFF;"> <div class="fpara" style="color: #000000; font-family: 'Times New Roman', Times, serif; font-size: 8pt; margin-top: 0pt; margin-left: -0.01pt; text-align: left;"><span style="padding-left: 2.66pt;">2,020,092</span></div> </td> <td class="gutter" style="width: 1.19%; border-bottom: none; font-size: 2pt; padding-top: 3pt; padding-bottom: 3pt; background-color: #CCEEFF;">​</td> <td class="gutter" style="width: 1.19%; border-bottom: none; font-size: 2pt; padding-top: 3pt; padding-bottom: 3pt; background-color: #CCEEFF;">​</td> <td style="width: 7.74%; text-align: left; vertical-align: bottom; white-space: nowrap; padding-top: 3pt; padding-bottom: 3pt; background-color: #CCEEFF;"> <div class="fpara" style="color: #000000; font-family: 'Times New Roman', Times, serif; font-size: 8pt; margin-top: 0pt; margin-left: 0.01pt; text-align: left;"><span style="padding-left: 2.66pt;">2,998,786</span></div> </td> <td class="gutter" style="width: 1.19%; border-bottom: none; font-size: 2pt; padding-top: 3pt; padding-bottom: 3pt; background-color: #CCEEFF;">​</td> <td class="gutter" style="width: 1.19%; border-bottom: none; font-size: 2pt; padding-top: 3pt; padding-bottom: 3pt; background-color: #CCEEFF;">​</td> <td style="width: 7.74%; text-align: left; vertical-align: bottom; white-space: nowrap; padding-top: 3pt; padding-bottom: 3pt; background-color: #CCEEFF;"> <div class="fpara" style="color: #000000; font-family: 'Times New Roman', Times, serif; font-size: 8pt; margin-top: 0pt; margin-left: 0.01pt; text-align: left;"><span style="padding-left: 2.66pt;">1,849,354</span></div> </td> </tr> <tr> <td style="width: 69.64%; text-align: left; vertical-align: bottom; padding-top: 3pt; padding-bottom: 3pt;"> <div class="fpara" style="color: #000000; font-family: 'Times New Roman', Times, serif; font-size: 8pt; margin-top: 0pt; margin-left: 20pt; text-indent: -10pt; text-align: left;">Plus (less), average year-over-year change in fair value of outstanding and unvested equity awards granted in prior years</div> </td> <td class="gutter" style="width: 1.19%; border-bottom: none; font-size: 2pt; padding-top: 3pt; padding-bottom: 3pt;">​</td> <td class="gutter" style="width: 1.19%; border-bottom: none; font-size: 2pt; padding-top: 3pt; padding-bottom: 3pt;">​</td> <td style="width: 7.74%; text-align: left; vertical-align: bottom; white-space: nowrap; padding-top: 3pt; padding-bottom: 3pt;"> <div class="fpara" style="color: #000000; font-family: 'Times New Roman', Times, serif; font-size: 8pt; margin-top: 0pt; margin-left: -0.01pt; text-align: left;"><span style="padding-left: 6pt;">(813,831)</span></div> </td> <td class="gutter" style="width: 1.19%; border-bottom: none; font-size: 2pt; padding-top: 3pt; padding-bottom: 3pt;">​</td> <td class="gutter" style="width: 1.19%; border-bottom: none; font-size: 2pt; padding-top: 3pt; padding-bottom: 3pt;">​</td> <td style="width: 7.74%; text-align: left; vertical-align: bottom; white-space: nowrap; padding-top: 3pt; padding-bottom: 3pt;"> <div class="fpara" style="color: #000000; font-family: 'Times New Roman', Times, serif; font-size: 8pt; margin-top: 0pt; margin-left: 0.01pt; text-align: left;"><span style="padding-left: 2.66pt;">1,691,604</span></div> </td> <td class="gutter" style="width: 1.19%; border-bottom: none; font-size: 2pt; padding-top: 3pt; padding-bottom: 3pt;">​</td> <td class="gutter" style="width: 1.19%; border-bottom: none; font-size: 2pt; padding-top: 3pt; padding-bottom: 3pt;">​</td> <td style="width: 7.74%; text-align: left; vertical-align: bottom; white-space: nowrap; padding-top: 3pt; padding-bottom: 3pt;"> <div class="fpara" style="color: #000000; font-family: 'Times New Roman', Times, serif; font-size: 8pt; margin-top: 0pt; margin-left: 0.01pt; text-align: left;"><span style="padding-left: 8.66pt;">871,718</span></div> </td> </tr> <tr> <td style="width: 69.64%; text-align: left; vertical-align: bottom; padding-top: 3pt; padding-bottom: 3pt; background-color: #CCEEFF;"> <div class="fpara" style="color: #000000; font-family: 'Times New Roman', Times, serif; font-size: 8pt; margin-top: 0pt; margin-left: 20pt; text-indent: -10pt; text-align: left;">Plus (less), average year-over-year change in fair value (from the end of the prior year through the vesting date) of equity awards granted in prior years that vested in the year</div> </td> <td class="gutter" style="width: 1.19%; border-bottom: none; font-size: 2pt; padding-top: 3pt; padding-bottom: 3pt; background-color: #CCEEFF;">​</td> <td class="gutter" style="width: 1.19%; border-bottom: none; font-size: 2pt; padding-top: 3pt; padding-bottom: 3pt; background-color: #CCEEFF;">​</td> <td style="width: 7.74%; text-align: left; vertical-align: bottom; white-space: nowrap; padding-top: 3pt; padding-bottom: 3pt; background-color: #CCEEFF;"> <div class="fpara" style="color: #000000; font-family: 'Times New Roman', Times, serif; font-size: 8pt; margin-top: 0pt; margin-left: -0.01pt; text-align: left;"><span style="padding-left: 6pt;">(477,748)</span></div> </td> <td class="gutter" style="width: 1.19%; border-bottom: none; font-size: 2pt; padding-top: 3pt; padding-bottom: 3pt; background-color: #CCEEFF;">​</td> <td class="gutter" style="width: 1.19%; border-bottom: none; font-size: 2pt; padding-top: 3pt; padding-bottom: 3pt; background-color: #CCEEFF;">​</td> <td style="width: 7.74%; text-align: left; vertical-align: bottom; white-space: nowrap; padding-top: 3pt; padding-bottom: 3pt; background-color: #CCEEFF;"> <div class="fpara" style="color: #000000; font-family: 'Times New Roman', Times, serif; font-size: 8pt; margin-top: 0pt; margin-left: 0.01pt; text-align: left;"><span style="padding-left: 2.66pt;">1,773,047</span></div> </td> <td class="gutter" style="width: 1.19%; border-bottom: none; font-size: 2pt; padding-top: 3pt; padding-bottom: 3pt; background-color: #CCEEFF;">​</td> <td class="gutter" style="width: 1.19%; border-bottom: none; font-size: 2pt; padding-top: 3pt; padding-bottom: 3pt; background-color: #CCEEFF;">​</td> <td style="width: 7.74%; text-align: left; vertical-align: bottom; white-space: nowrap; padding-top: 3pt; padding-bottom: 3pt; background-color: #CCEEFF;"> <div class="fpara" style="color: #000000; font-family: 'Times New Roman', Times, serif; font-size: 8pt; margin-top: 0pt; margin-left: 0.01pt; text-align: left;"><span style="padding-left: 8.66pt;">363,631</span></div> </td> </tr> <tr> <td style="width: 69.64%; text-align: left; vertical-align: bottom; padding-top: 3pt; padding-bottom: 3pt;"> <div class="fpara" style="color: #000000; font-family: 'Times New Roman', Times, serif; font-size: 8pt; margin-top: 0pt; margin-left: 10pt; text-align: left;">Less, average prior year-end fair value for any equity awards forfeited in the year</div> </td> <td class="gutter" style="width: 1.19%; border-bottom: none; font-size: 2pt; padding-top: 3pt; padding-bottom: 3pt;">​</td> <td class="gutter" style="width: 1.19%; border-bottom: none; font-size: 2pt; padding-top: 3pt; padding-bottom: 3pt;">​</td> <td style="width: 7.74%; text-align: left; vertical-align: bottom; white-space: nowrap; padding-top: 3pt; padding-bottom: 3pt;"> <div class="fpara" style="color: #000000; font-family: 'Times New Roman', Times, serif; font-size: 8pt; margin-top: 0pt; margin-left: -0.01pt; text-align: left;"><span style="padding-left: 26.66pt;">—</span></div> </td> <td class="gutter" style="width: 1.19%; border-bottom: none; font-size: 2pt; padding-top: 3pt; padding-bottom: 3pt;">​</td> <td class="gutter" style="width: 1.19%; border-bottom: none; font-size: 2pt; padding-top: 3pt; padding-bottom: 3pt;">​</td> <td style="width: 7.74%; text-align: left; vertical-align: bottom; white-space: nowrap; padding-top: 3pt; padding-bottom: 3pt;"> <div class="fpara" style="color: #000000; font-family: 'Times New Roman', Times, serif; font-size: 8pt; margin-top: 0pt; margin-left: 0.01pt; text-align: left;"><span style="padding-left: 10pt;">(55,492)</span></div> </td> <td class="gutter" style="width: 1.19%; border-bottom: none; font-size: 2pt; padding-top: 3pt; padding-bottom: 3pt;">​</td> <td class="gutter" style="width: 1.19%; border-bottom: none; font-size: 2pt; padding-top: 3pt; padding-bottom: 3pt;">​</td> <td style="width: 7.74%; text-align: left; vertical-align: bottom; white-space: nowrap; padding-top: 3pt; padding-bottom: 3pt;"> <div class="fpara" style="color: #000000; font-family: 'Times New Roman', Times, serif; font-size: 8pt; margin-top: 0pt; margin-left: 0.01pt; text-align: left;"><span style="padding-left: 6pt;">(165,096)</span></div> </td> </tr> <tr> <td style="width: 69.64%; text-align: left; vertical-align: bottom; padding-top: 3pt; padding-bottom: 3pt; background-color: #CCEEFF;"> <div class="fpara" style="color: #000000; font-family: 'Times New Roman', Times, serif; font-size: 8pt; font-weight: bold; margin-top: 0pt; margin-left: 0pt; text-align: left;">Average Compensation Actually Paid to Non-PEO NEOs</div> </td> <td class="gutter" style="width: 1.19%; border-bottom: none; font-size: 2pt; padding-top: 3pt; padding-bottom: 3pt; background-color: #CCEEFF;">​</td> <td class="gutter" style="width: 1.19%; border-bottom: none; font-size: 2pt; padding-top: 3pt; padding-bottom: 3pt; background-color: #CCEEFF;">​</td> <td style="width: 7.74%; text-align: left; vertical-align: bottom; white-space: nowrap; padding-top: 3pt; padding-bottom: 3pt; background-color: #CCEEFF;"> <div class="fpara" style="color: #000000; font-family: 'Times New Roman', Times, serif; font-size: 8pt; font-weight: bold; margin-top: 0pt; margin-left: -0.01pt; text-align: left;"><span style="padding-left: 2.66pt;">1,452,633</span></div> </td> <td class="gutter" style="width: 1.19%; border-bottom: none; font-size: 2pt; padding-top: 3pt; padding-bottom: 3pt; background-color: #CCEEFF;">​</td> <td class="gutter" style="width: 1.19%; border-bottom: none; font-size: 2pt; padding-top: 3pt; padding-bottom: 3pt; background-color: #CCEEFF;">​</td> <td style="width: 7.74%; text-align: left; vertical-align: bottom; white-space: nowrap; padding-top: 3pt; padding-bottom: 3pt; background-color: #CCEEFF;"> <div class="fpara" style="color: #000000; font-family: 'Times New Roman', Times, serif; font-size: 8pt; font-weight: bold; margin-top: 0pt; margin-left: 0.01pt; text-align: left;"><span style="padding-left: 2.66pt;">7,254,142</span></div> </td> <td class="gutter" style="width: 1.19%; border-bottom: none; font-size: 2pt; padding-top: 3pt; padding-bottom: 3pt; background-color: #CCEEFF;">​</td> <td class="gutter" style="width: 1.19%; border-bottom: none; font-size: 2pt; padding-top: 3pt; padding-bottom: 3pt; background-color: #CCEEFF;">​</td> <td style="width: 7.74%; text-align: left; vertical-align: bottom; white-space: nowrap; padding-top: 3pt; padding-bottom: 3pt; background-color: #CCEEFF;"> <div class="fpara" style="color: #000000; font-family: 'Times New Roman', Times, serif; font-size: 8pt; font-weight: bold; margin-top: 0pt; margin-left: 0.01pt; text-align: left;"><span style="padding-left: 2.66pt;">3,630,213</span></div> </td> </tr> </table> 2568935 4523739 2353552 -1844815 -3677542 -1642946 2020092 2998786 1849354 -813831 1691604 871718 -477748 1773047 363631 0 -55492 -165096 1452633 7254142 3630213 3.45 <table border="0" cellpadding="0" cellspacing="0" style="margin-top: 3pt; margin-left: 0pt;"> <tr> <td style="width: 20pt; text-align: left; vertical-align: top;"> <div style="color: #000000; font-family: 'Times New Roman', Times, serif; font-size: 8pt;">(6)<br/> </div> </td> <td style="vertical-align: top;"> <div style="color: #000000; font-family: 'Times New Roman', Times, serif; font-size: 8pt; text-align: left;">The peer group used for this purpose is the CRSP Total Return Index for Nasdaq Pharmaceutical Stocks.</div> </td> </tr> </table> <div class="h3" style="color: #000000; font-family: 'Times New Roman', Times, serif; font-size: 10pt; font-style: italic; font-weight: bold; margin-top: 7pt; margin-left: 0pt; text-align: left;">Description of Certain Relationships between Information Presented in the Pay Versus Performance Table</div> <div style="display:none;"><br/></div> <div class="para" style="color: #000000; font-family: 'Times New Roman', Times, serif; font-size: 10pt; margin-top: 6pt; margin-left: 0pt; text-indent: 20pt; text-align: justify;">As described in more detail in the “Compensation Discussion and Analysis” section above, the Company’s executive compensation program reflects a variable-pay-for-performance philosophy. It is based on market best practices and is designed to ensure that it is appropriately risk-based and competitive with similar companies in our industry. The Company’s primary objectives for our executive compensation program are described on page <a href="#OBJ">29</a> of the “Compensation Discussion and Analysis,” and the pre-established corporate objectives used to determine the variable component of executive compensation for 2022 (i.e., cash bonus under the AIP and 2022 long-term equity grants) are described on page <a href="#PCOBJ">33</a>. While the Company uses several performance measures to align executive compensation with Company performance, not all of those Company measures are presented in the “Pay Versus Performance” table above. Further, not all of the Company’s performance measures are “financial performance measures” as defined above in note 8 to the “Pay Versus Performance” table. For example, as a growing commercial-stage biotechnology company that discovers and commercializes novel, oral, small-molecule medicines, some of our performance measures relate to developments in the Company’s product pipeline and to building a robust and adaptable organization. The Company generally seeks to incentivize long-term performance of the Company as a whole and, therefore, does not specifically align the Company’s performance measures with “compensation actually paid” (as computed in accordance with Item 402(v) of Regulation S-K) for a particular year, which can be impacted in large part by changes in stock price. </div> <div class="h4" style="color: #000000; font-family: 'Times New Roman', Times, serif; font-size: 10pt; font-style: italic; margin-top: 8pt; margin-left: 0pt; text-align: left;">Compensation Actually Paid, Cumulative TSR, and Peer Group TSR</div> <div class="fpara" style="color: #000000; font-family: 'Times New Roman', Times, serif; font-size: 10pt; margin-top: 13.75pt; text-align: center;"><img alt="graphic" src="ny20007126x1_barchart01.jpg" style="height: 344px; width: 612px;"/><br/> </div> <div class="fpara" style="color: #000000; font-family: 'Times New Roman', Times, serif; font-size: 10pt; margin-top: 0pt; margin-left: 0pt; text-align: left;"> </div> <div class="h4" style="color: #000000; font-family: 'Times New Roman', Times, serif; font-size: 10pt; font-style: italic; margin-top: 8pt; margin-left: 0pt; text-align: left;">Compensation Actually Paid, Cumulative TSR, and Peer Group TSR</div> <div class="fpara" style="color: #000000; font-family: 'Times New Roman', Times, serif; font-size: 10pt; margin-top: 13.75pt; text-align: center;"><img alt="graphic" src="ny20007126x1_barchart01.jpg" style="height: 344px; width: 612px;"/><br/> </div> <div class="fpara" style="color: #000000; font-family: 'Times New Roman', Times, serif; font-size: 10pt; margin-top: 0pt; margin-left: 0pt; text-align: left;"> </div> <div class="h4" style="color: #000000; font-family: 'Times New Roman', Times, serif; font-size: 10pt; font-style: italic; margin-top: 6.75pt; margin-left: 0pt; text-align: left;">Compensation Actually Paid and Net Loss</div> <div class="fpara" style="color: #000000; font-family: 'Times New Roman', Times, serif; font-size: 10pt; margin-top: 14.25pt; text-align: center;"><img alt="graphic" src="ny20007126x1_barchart02.jpg" style="height: 359px; width: 612px;"/><br/> </div> <div class="fpara" style="color: #000000; font-family: 'Times New Roman', Times, serif; font-size: 10pt; margin-top: 0pt; margin-left: 0pt; text-align: left;"> </div> <div class="h4" style="color: #000000; font-family: 'Times New Roman', Times, serif; font-size: 10pt; font-style: italic; margin-top: 8.5pt; margin-left: 0pt; text-align: left;">Compensation Actually Paid and ORLADEYO Sales</div> <div class="fpara" style="color: #000000; font-family: 'Times New Roman', Times, serif; font-size: 10pt; margin-top: 14.25pt; text-align: center;"><img alt="graphic" src="ny20007126x1_barchart03.jpg" style="height: 342px; width: 612px;"/><br/> </div> <div class="fpara" style="color: #000000; font-family: 'Times New Roman', Times, serif; font-size: 10pt; margin-top: 0pt; margin-left: 0pt; text-align: left;"> </div> <div class="h3" style="color: #000000; font-family: 'Times New Roman', Times, serif; font-size: 10pt; font-style: italic; font-weight: bold; margin-top: 6.75pt; margin-left: 0pt; text-align: left;">Performance Measures</div> <div style="display:none;"><br/></div> <div class="para" style="color: #000000; font-family: 'Times New Roman', Times, serif; font-size: 10pt; margin-top: 6pt; margin-left: 0pt; text-indent: 20pt; text-align: justify;">As disclosed above under “Description of Certain Relationships between Information Presented in the Pay Versus Performance Table,” the Company uses several performance measures to align executive compensation with Company performance, not all of which are presented in the “Pay Versus Performance” table. These performance measures include the pre-established corporate objectives for 2022, as described in the “Compensation Discussion and Analysis” section, and reflect the Company’s variable pay-for-performance philosophy. As a growing company that engages heavily in research and development, the majority of our corporate objectives were not “financial performance measures,” as defined by SEC rules. However, they did include one financial performance measure for ORLADEYO sales. Accordingly, the most important financial performance measure(s) used by the Company to link executive “compensation actually paid” to the Company’s NEOs, for the most recently completed fiscal year, to the Company’s performance is as follows:</div> <table border="0" cellpadding="0" cellspacing="0" style="margin-top: 6pt; margin-left: 20pt;"> <tr> <td style="width: 20pt; text-align: left; vertical-align: top;"> <div style="color: #000000; font-family: 'Times New Roman', Times, serif; font-size: 10pt;">•</div> </td> <td style="vertical-align: top;"> <div style="color: #000000; font-family: 'Times New Roman', Times, serif; font-size: 10pt; text-align: left;">ORLADEYO sales.</div> </td> </tr> </table> <div style="display:none;"><br/></div> <div class="para" style="color: #000000; font-family: 'Times New Roman', Times, serif; font-size: 10pt; margin-top: 6pt; margin-left: 0pt; text-indent: 20pt; text-align: justify;">In addition to our financial performance measures, the Company views stock price as a key driver of value for all of our equity awards and, in particular, the stock options, which have no value unless the stock price appreciates from the date of grant.</div> ORLADEYO sales