000 - Document - Document And Entity Information link:calculationLink link:definitionLink link:presentationLink 001 - Statement - Consolidated Balance Sheets link:calculationLink link:definitionLink link:presentationLink 002 - Statement - Consolidated Balance Sheets (Parentheticals) link:calculationLink link:definitionLink link:presentationLink 003 - Statement - Consolidated Statements of Comprehensive Loss link:calculationLink link:definitionLink link:presentationLink 004 - Statement - Consolidated Statements of Cash Flows link:calculationLink link:definitionLink link:presentationLink 005 - Statement - Consolidated Statements of Stockholders' Equity (Deficit) link:calculationLink link:definitionLink link:presentationLink 006 - Statement - Consolidated Statements of Stockholders' Equity (Deficit) (Parentheticals) link:calculationLink link:definitionLink link:presentationLink 007 - Disclosure - Note 1 - Significant Accounting Policies and Concentrations of Risk link:calculationLink link:definitionLink link:presentationLink 008 - Disclosure - Note 2 - Property and Equipment link:calculationLink link:definitionLink link:presentationLink 009 - Disclosure - Note 3 - Royalty Monetization link:calculationLink link:definitionLink link:presentationLink 010 - Disclosure - Note 4 - Senior Credit Facility link:calculationLink link:definitionLink link:presentationLink 011 - Disclosure - Note 5 - Lease Obligations and Other Contingencies link:calculationLink link:definitionLink link:presentationLink 012 - Disclosure - Note 6 - Stockholders' Equity link:calculationLink link:definitionLink link:presentationLink 013 - Disclosure - Note 7 - Stock-based Compensation link:calculationLink link:definitionLink link:presentationLink 014 - Disclosure - Note 8 - Income Taxes link:calculationLink link:definitionLink link:presentationLink 015 - Disclosure - Note 9 - Employee 401(k) Plan link:calculationLink link:definitionLink link:presentationLink 016 - Disclosure - Note 10 - Collaborative and Other Research and Development Contracts link:calculationLink link:definitionLink link:presentationLink 017 - Disclosure - Note 11 - Quarterly Financial Information (Unaudited) link:calculationLink link:definitionLink link:presentationLink 018 - Disclosure - Note 12 - Recent Accounting Pronouncements link:calculationLink link:definitionLink link:presentationLink 019 - Disclosure - Note 13 - Subsequent Event link:calculationLink link:definitionLink link:presentationLink 020 - Disclosure - Significant Accounting Policies (Policies) link:calculationLink link:definitionLink link:presentationLink 021 - Disclosure - Note 1 - Significant Accounting Policies and Concentrations of Risk (Tables) link:calculationLink link:definitionLink link:presentationLink 022 - Disclosure - Note 2 - Property and Equipment (Tables) link:calculationLink link:definitionLink link:presentationLink 023 - Disclosure - Note 4 - Senior Credit Facility (Tables) link:calculationLink link:definitionLink link:presentationLink 024 - Disclosure - Note 5 - Lease Obligations and Other Contingencies (Tables) link:calculationLink link:definitionLink link:presentationLink 025 - Disclosure - Note 7 - Stock-based Compensation (Tables) link:calculationLink link:definitionLink link:presentationLink 026 - Disclosure - Note 8 - Income Taxes (Tables) link:calculationLink link:definitionLink link:presentationLink 027 - Disclosure - Note 11 - Quarterly Financial Information (Unaudited) (Tables) link:calculationLink link:definitionLink link:presentationLink 028 - Disclosure - Note 1 - Significant Accounting Policies and Concentrations of Risk (Details Textual) link:calculationLink link:definitionLink link:presentationLink 029 - Disclosure - Note 1 - Significant Accounting Policies and Concentrations of Risk - Fair Value of the Company's Investments by Type (Details) link:calculationLink link:definitionLink link:presentationLink 030 - Disclosure - Note 1 - Significant Accounting Policies and Concentrations of Risk - Scheduled Maturity for the Company's Investments (Details) link:calculationLink link:definitionLink link:presentationLink 031 - Disclosure - Note 1 - Significant Accounting Policies and Concentrations of Risk- Summary of Receivables (Details) link:calculationLink link:definitionLink link:presentationLink 032 - Disclosure - Note 1 - Significant Accounting Policies and Concentrations of Risk - Accrued Expenses (Details) link:calculationLink link:definitionLink link:presentationLink 033 - Disclosure - Note 1 - Significant Accounting Policies and Concentrations of Risk - Cumulative Effective Adopted Accounting Pronouncement (Details) link:calculationLink link:definitionLink link:presentationLink 034 - Disclosure - Note 1 - Significant Accounting Policies and Concentrations of Risk - Summary of Revenues (Details) link:calculationLink link:definitionLink link:presentationLink 035 - Disclosure - Note 2 - Property and Equipment (Details Textual) link:calculationLink link:definitionLink link:presentationLink 036 - Disclosure - Note 2 - Property and Equipment - Property and Equipment (Details) link:calculationLink link:definitionLink link:presentationLink 037 - Disclosure - Note 3 - Royalty Monetization (Details Textual) link:calculationLink link:definitionLink link:presentationLink 038 - Disclosure - Note 4 - Senior Credit Facility (Details Textual) link:calculationLink link:definitionLink link:presentationLink 039 - Disclosure - Note 4 - Senior Credit Facility - Scheduled Principal Repayments of the Credit Facility (Details) link:calculationLink link:definitionLink link:presentationLink 040 - Disclosure - Note 5 - Lease Obligations and Other Contingencies (Details Textual) link:calculationLink link:definitionLink link:presentationLink 041 - Disclosure - Note 5 - Lease Obligations and Other Contingencies - Minimum Payments under Operating Lease Obligations (Details) link:calculationLink link:definitionLink link:presentationLink 042 - Disclosure - Note 6 - Stockholders' Equity (Details Textual) link:calculationLink link:definitionLink link:presentationLink 043 - Disclosure - Note 7 - Stock-based Compensation (Details Textual) link:calculationLink link:definitionLink link:presentationLink 044 - Disclosure - Note 7 - Stock-Based Compensation - Stock-based Compensation Allocation (Details) link:calculationLink link:definitionLink link:presentationLink 045 - Disclosure - Note 7 - Stock-based Compensation - Stock Incentive Plan Activities (Details) link:calculationLink link:definitionLink link:presentationLink 046 - Disclosure - Note 7 - Stock-based Compensation - Weighted Average Assumptions for Stock Option Awards Granted to Employees and Directors Under the Incentive Plan (Details) link:calculationLink link:definitionLink link:presentationLink 047 - Disclosure - Note 7 - Share-Based Compensation - Number of Stock Option Awards Exercisable and their Weighted Average Exercise Price (Details) link:calculationLink link:definitionLink link:presentationLink 048 - Disclosure - Note 7 - Share-Based Compensation - Changes in the Number and Weighted-Average Grant-Date Fair Value (Details) link:calculationLink link:definitionLink link:presentationLink 049 - Disclosure - Note 8 - Income Taxes (Details Textual) link:calculationLink link:definitionLink link:presentationLink 050 - Disclosure - Note 8 - Income Taxes - Differences Between the Company's Effective Tax Rate and the Statutory Tax Rate (Details) link:calculationLink link:definitionLink link:presentationLink 051 - Disclosure - Note 8 - Income Taxes - Differences Between the Company's Effective Tax Rate and the Statutory Tax Rate (Details) (Parentheticals) link:calculationLink link:definitionLink link:presentationLink 052 - Disclosure - Note 8 - Income Taxes - Reconciliation of Beginning and Ending Amount of Unrecognized Tax Benefits (Details) link:calculationLink link:definitionLink link:presentationLink 053 - Disclosure - Note 8 - Income Taxes - Components of Deferred Tax Assets and Liabilities (Details) link:calculationLink link:definitionLink link:presentationLink 054 - Disclosure - Note 9 - Employee 401(k) Plan (Details Textual) link:calculationLink link:definitionLink link:presentationLink 055 - Disclosure - Note 10 - Collaborative and Other Research and Development Contracts (Details Textual) link:calculationLink link:definitionLink link:presentationLink 056 - Disclosure - Note 11 - Quarterly Financial Information (Unaudited) - Schedule of Quarterly Information (Details) link:calculationLink link:definitionLink link:presentationLink 057 - Disclosure - Note 12 - Recent Accounting Pronouncements (Details Textual) link:calculationLink link:definitionLink link:presentationLink 058 - Disclosure - Note 13 - Subsequent Event (Details Textual) link:calculationLink link:definitionLink link:presentationLink