BIOCRYST TO RELEASE FOURTH QUARTER AND YEAR END 2002 FINANCIAL RESULTS

January 21, 2003
BIOCRYST TO RELEASE FOURTH QUARTER AND YEAR END 2002 FINANCIAL RESULTS Birmingham, Alabama - January 21, 2003 - BioCryst Pharmaceuticals, Inc. (Nasdaq NM: BCRX) will release its financial results for the fourth quarter and year ended 2002, before the market opens on Wednesday, February 5, 2003. The Company will also sponsor a conference call at 10:00 a.m. EST. Interested investors can listen to the call live over the Internet from the investor relations website at www.biocryst.com or by dialing 1-800-289-0438, and providing the passcode number 626972.

What: BioCryst Pharmaceuticals, Inc. Fourth Quarter and Year End 2002 Financial Results Conference Call
When: Wednesday, February 5, 2003, 10:00 a.m., EST
Where: http://www.firstcallevents.com/service/ajwz372733839gf12.html
How: Live over the Internet -- Simply log on to the web at the address above, or Live conference call -- Dial 1-800-289-0438, passcode 626972.
Founded in 1986, BioCryst Pharmaceuticals, Inc. is a biopharmaceutical company focused on the development of small-molecule pharmaceuticals to prevent, treat, and control viral and cardiovascular diseases and cancer.

For those unable to listen at the designated time, the webcast will remain available for replay over BioCryst's investor relations website until February 21, 2003. A conference call replay will also be available from approximately 1:00 p.m. EST on Wednesday, February 5, 2003 through midnight Friday, February 7, 2003 by dialing 1-888-203-1112 and entering passcode 626972.