BIOCRYST TO RELEASE FOURTH QUARTER AND YEAR-END 2003 FINANCIAL RESULTS

January 23, 2004
BIOCRYST TO RELEASE FOURTH QUARTER AND YEAR-END 2003 FINANCIAL RESULTS

Birmingham, Alabama - January 23, 2004 - BioCryst Pharmaceuticals, Inc. (Nasdaq NM: BCRX) will release its financial results for the fourth quarter and year ended 2003, before the market opens on Wednesday, February 4, 2004. The Company will also sponsor a conference call at 10:00 a.m. EST. Interested investors can listen to the call live over the Internet from the investor relations website at www.biocryst.com or by dialing 1-800-361-0912, and providing the passcode number 311037.

What:
BioCryst Pharmaceuticals, Inc. Fourth Quarter and Year End 2003 Financial Results Conference Call

When:
Wednesday, February 4, 2004, 10:00 a.m., EST

Where:
http://www.firstcallevents.com/service/ajwz396163792gf12.html

How:
Live over the Internet -- Simply log on to the web at the address above, or Live conference call -- Dial 1-800-361-0912, passcode 311037.

Founded in 1986, BioCryst Pharmaceuticals, Inc. is a biopharmaceutical company focused on the development of small-molecule pharmaceuticals to treat cancer, cardiovascular and autoimmune diseases and viral infections.

For those unable to listen at the designated time, the webcast will remain available for replay over BioCryst's investor relations website until March 4, 2004. A conference call replay will also be available from approximately 1:00 p.m. EST on Wednesday, February 4, 2004 through midnight Friday, February 6, 2004 by dialing 1-888-203-1112 and entering passcode 311037.