BIOCRYST TO RELEASE FOURTH QUARTER AND YEAR END 2004 FINANCIAL RESULTS

January 21, 2005
BIOCRYST TO RELEASE FOURTH QUARTER AND YEAR END 2004 FINANCIAL RESULTS

Birmingham, Alabama - January 24, 2005 - BioCryst Pharmaceuticals, Inc. (Nasdaq NM: BCRX) will release its financial results for the fourth quarter and year ended 2004, before the market opens on Wednesday, February 2, 2005. The Company will also sponsor a conference call at 10:00 a.m. ET. Interested investors can listen to the call live over the Internet from the investor relations website at www.biocryst.com or by dialing 1-800-289-0569, and providing the passcode number 9141867.

What: BioCryst Pharmaceuticals, Inc. Fourth Quarter and Year End 2004 Financial Results Conference Call

When: Wednesday, February 2, 2004, 10:00 a.m., ET

Where: http://phx.corporate-ir.net/playerlink.zhtml?c=74878&s=wm&e=1003891

How: Live over the Internet -- Simply log on to the web at the address above, or Live conference call -- Dial 1-800-289-0569, passcode 9141867.

Founded in 1986, BioCryst Pharmaceuticals, Inc. is a biopharmaceutical company focused on the development of small-molecule pharmaceuticals to treat cancer, cardiovascular and autoimmune diseases and viral infections.

For those unable to listen at the designated time, the webcast will remain available for replay over BioCryst's investor relations website until April 30, 2005. A conference call replay will also be available from approximately 1:00 p.m. ET on Wednesday, February 2, 2005 through midnight Friday, February 4, 2005 by dialing 1-888-203-1112 and entering passcode 9141867.

Contacts:
BioCryst Pharmaceuticals, Inc.
Michael A. Darwin
Chief Financial Officer
(205) 444-4600

Noonan/Russo
Sharon Weinstein (Investors)
(212) 845-4271
Wendy Lau (Media)
(212) 845-4272