BIOCRYST SCHEDULED TO PRESENT AT TWO UPCOMING HEALTH CARE CONFERENCES

February 22, 2005
BioCryst Scheduled to Present at Two Upcoming Health Care Conferences

Birmingham, Alabama - February 23, 2005 - BioCryst Pharmaceuticals, Inc. (Nasdaq NM: BCRX) announced that Charles E. Bugg, Ph.D., Chairman and CEO, will be presenting at the Leerink Swann & Company/MEDACorp Inaugural Health Care Conference on Tuesday, March 1, 2005, at 11:00 a.m. ET and the Wells Fargo Securities 2005 Healthcare Conference on Wednesday, March 2, 2005, at 2:15 p.m. ET. Interested investors can listen to the presentations live over the Internet during the conferences at the following addresses:

What: BioCryst Pharmaceuticals, Inc. Presentation at the Leerink Swann & Company/MEDACorp Inaugural Health Care Conference

When: Tuesday, March 1, 2005, at 11:00 a.m. ET

Where:www.wsw.com/webcast/leerink/bcrx/

What: BioCryst Pharmaceuticals, Inc. Presentation at the Wells Fargo Securities 2005 Healthcare Conference

When: Wednesday, March 2, 2005, at 2:15 p.m. ET

Where: http://www.wsw.com/webcast/wfc/bcrx/

How: Live over the Internet -- Simply log on to the web at the addresses above

For those unable to listen at the designated time, both webcasts will remain available for replay for 90 days following the conferences.

Founded in 1986, BioCryst Pharmaceuticals, Inc. is a biopharmaceutical company focused on the development of small-molecule pharmaceuticals to treat cancer, cardiovascular and autoimmune diseases, and viral infections.

Contacts:

BioCryst Pharmaceuticals, Inc.
Mike Darwin
Chief Financial Officer
(205) 444-4600

Noonan/Russo
Sharon Weinstein (Investors)
(212) 845-4271
Wendy Lau (Media)
(212) 845-4272